Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gregory Poffenberger"'
Autor:
Marcela Brissova, Rachana Haliyur, Diane Saunders, Shristi Shrestha, Chunhua Dai, David M. Blodgett, Rita Bottino, Martha Campbell-Thompson, Radhika Aramandla, Gregory Poffenberger, Jill Lindner, Fong Cheng Pan, Matthias G. von Herrath, Dale L. Greiner, Leonard D. Shultz, May Sanyoura, Louis H. Philipson, Mark Atkinson, David M. Harlan, Shawn E. Levy, Nripesh Prasad, Roland Stein, Alvin C. Powers
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2667-2676 (2018)
Summary: Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual
Externí odkaz:
https://doaj.org/article/179fb49bdb1e47cd9d5843dc1eb65012
Autor:
John T. Walker, Radhika Aramandla, Alvin C. Powers, Marcela Brissova, Gregory Poffenberger, Matthew Ishahak, Ashutosh Agarwal, Rachana Haliyur, Adolfo Garcia-Ocaña, Conrad Reihsmann, Peng Wang, Joseph R. Luchsinger, Heather A. Nelson, Rita Bottino, Diane C. Saunders
SUMMARYG-protein-coupled-receptors (GPCRs) modulate insulin secretion from β cells and glucagon secretion from α cells. Here, we developed an integrated approach to study the function of primary human islet cells using genetically modified pseudois
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbb728f63f59c7bd958e490a5ea3863
Autor:
Matthias von Herrath, Rachana Haliyur, Dale L. Greiner, Chunhua Dai, Alvin C. Powers, Louis H. Philipson, Radhika Aramandla, Mark A. Atkinson, Shawn Levy, Fong Cheng Pan, Diane C. Saunders, Jill Lindner, Nripesh Prasad, Rita Bottino, Leonard D. Shultz, Marcela Brissova, Martha Campbell-Thompson, Gregory Poffenberger, May Sanyoura, David M. Harlan, Roland Stein, David M. Blodgett, Shristi Shrestha
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2667-2676 (2018)
Cell reports
Cell reports
SUMMARY Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual
Autor:
Nathaniel J. Hart, Ariel H. Thames, Nripesh Prasad, Mitchell L. Drumm, Marcela Brissova, Radhika Aramandla, Alvin C. Powers, David A. Jacobson, Sally C. Kent, Chunhua Dai, Appakalai N. Balamurugan, William S. Bush, Prasanna K. Dadi, Jenny Aurielle B. Babon, Austin Bautista, Rita Bottino, Gregory Poffenberger, Cody Fayolle, Megan E DeNicola, Patrick E. MacDonald, Aliya F. Spigelman
Publikováno v:
JCI insight. 3(8)
Cystic fibrosis-related (CF-related) diabetes (CFRD) is an increasingly common and devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the underlying causes of CFRD are unclear. Here, we examined cystic fibrosis tra
Autor:
Gregory Poffenberger, Chunhua Dai, Alvin C. Powers, Wendell E. Nicholson, Courtney S. Thompson, Nora S. Kayton, Joseph Henske, Marcela Brissova, Radhika Aramandla, William S. Bush, Alena Shostak
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 308:E592-E602
Human islet research is providing new insights into human islet biology and diabetes, using islets isolated at multiple US centers from donors with varying characteristics. This creates challenges for understanding, interpreting, and integrating rese
Autor:
Nimit Jain, Xueying Gu, Jing Wang, Yinghua Liu, Ronald W. Alfa, Alvin C. Powers, Lutz Kockel, Gregory Poffenberger, Kathleen-Rose Skelly, Sangbin Park, Seung K. Kim
Publikováno v:
Cell Metabolism. 21:323-334
SummaryDecretins, hormones induced by fasting that suppress insulin production and secretion, have been postulated from classical human metabolic studies. From genetic screens, we identified Drosophila Limostatin (Lst), a peptide hormone that suppres