Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gregory P. Rouen"'
Autor:
Ying-Duo Gao, Gregory P. Rouen, Milton L. Hammond, Paula M.D. Fitzgerald, Gail G. Hammond, Jeffrey H. Toney, Steven H. Olson, Mark L. Greenlee, Nandini Sharma, James M. Balkovec
Publikováno v:
Journal of Biological Chemistry. 276:31913-31918
IMP-1 metallo-beta-lactamase (class B) is a plasmid-borne zinc metalloenzyme that efficiently hydrolyzes beta-lactam antibiotics, including carbapenems, rendering them ineffective. Because IMP-1 has been found in several clinically important carbapen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12de33bf43686b173d534bb66e99b5f4
https://doi.org/10.1074/jbc.m104742200
https://doi.org/10.1074/jbc.m104742200
Autor:
Frank P. DiNinno, Gregory P. Rouen, Jon G. Sundelof, Joanne B. Laub, Mark L. Greenlee, Joann Huber, Gail G. Hammond, Milton L. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3225-3230
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32811c5ac5a3f04df24eaa1c565a4afa
https://doi.org/10.1016/s0960-894x(99)00567-3
https://doi.org/10.1016/s0960-894x(99)00567-3
Autor:
Frank P. DiNinno, Joann Huber, Jon G. Sundelof, Milton L. Hammond, Gail G. Hammond, Mark L. Greenlee, Joanne B. Laub, Gregory P. Rouen
Publikováno v:
ChemInform. 31
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf205825e25b28594030ec37e68736b
https://doi.org/10.1002/chin.200008261
https://doi.org/10.1002/chin.200008261
Autor:
Wei Cui, Heiko Schadow, Gregory P. Rouen, Roger J. Bontems, Robert B. Bates, Kelly J. McClure, Jennifer J. Burns, Stuart R. Taylor, George R. Pettit, Sriyani Caldera, Gayle V. Yarick, Chad C. Stessman, Vicky H. Vu, Kennard G. Brusoe, Jianxing Zhang, Sanjeev Gangwar, Michelle R. Gramme
Publikováno v:
Journal of the American Chemical Society. 119:2111-2113
The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f08f4a095441657fec59b3b82dd8ff6
https://doi.org/10.1021/ja963857y
https://doi.org/10.1021/ja963857y
Autor:
Ayesha Sitlani, Dennis M. Zaller, Donald W. Graham, Edward A. O'Neill, Cameron J. Smith, Ester Carballo-Jane, Milton L. Hammond, Gool F. Patel, Chris M. Thompson, Paul Mazur, Ting-Ting Yamin, James R. Tata, Silvi Luell, Joanne M. Williamson, Michael J. Forrest, Monica Einstein, Shilpa Pandit, Georgianna Harris, Gregory P. Rouen, Joseph C. Santoro, Theresa M. Kelly, Chuanlin F. Wang, James M. Balkovec, Lan Ge, Douglas K. Miller, Amjad Ali, Scott K. Smith
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(11)
A novel series of selective ligands for the human glucocorticoid receptor is described. Structure–activity studies focused on variation of B-ring size, ketal ring size, and ketal substitution. These analogs were found to be potent and selective lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed1756db800109474facb21e75438ce
https://pubmed.ncbi.nlm.nih.gov/15911283
https://pubmed.ncbi.nlm.nih.gov/15911283