Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gregory P. Howard"'
Autor:
Gregory P. Howard, Nicole G. Bender, Prachi Khare, Borja López-Gutiérrez, Vincent Nyasembe, William J. Weiss, Jerry W. Simecka, Timothy Hamerly, Hai-Quan Mao, Rhoel R. Dinglasan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A successful malaria transmission blocking vaccine (TBV) requires the induction of a high antibody titer that leads to abrogation of parasite traversal of the mosquito midgut following ingestion of an infectious bloodmeal, thereby blocking the cascad
Externí odkaz:
https://doaj.org/article/b57a063ffd7d4e87aa007842f02ce0da
Autor:
Kirsty L. Wilson, Gregory P. Howard, Heather Coatsworth, Rhoel R. Dinglasan, Hai-Quan Mao, Magdalena Plebanski
Publikováno v:
Vaccines, Vol 8, Iss 2, p 261 (2020)
Sustained immune responses, particularly antibody responses, are key for protection against many endemic infectious diseases. Antibody responses are often accompanied by T helper (Th) cell immunity. Herein we study small biodegradable poly (ethylene
Externí odkaz:
https://doaj.org/article/3c9af4c385324c2a82760accc28d0730
Autor:
Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, Brianna N Smith, Macey J Slota, Elizabeth M Reynolds, Soumita Goswami, Michael R Savona, Frank M Mason, Taekyu Lee, Stephen Fesik, Qi Liu, William P Tansey
Publikováno v:
eLife, Vol 12 (2024)
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site that tethers WDR5 to chromatin. WIN site inhibi
Externí odkaz:
https://doaj.org/article/843d9e309e8c4e569cdd20374b77da61
Akademický článek
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Autor:
Tianqi Nie, Lixin Liu, Zhiyu He, Jinchang Zhu, Il Minn, Jesus Pacheco-Torres, Kuntao Chen, Pengfei Zhao, Gregory P. Howard, Hai-Quan Mao, Yongming Chen, Zaver M. Bhujwalla
Publikováno v:
Nano Research. 14:2749-2761
Levodopa (L-DOPA), a precursor of dopamine, is commonly prescribed for the treatment of the Parkinson’s disease (PD). However, oral administration of levodopa results in a high level of homocysteine in the peripheral circulation, thereby elevating
Autor:
Bei Cheng, Xiyu Ke, José Luís Guedes dos Santos, Hai-Quan Mao, May Tun Saung, Haoyu Tang, Gregory P. Howard
Publikováno v:
Advanced Drug Delivery Reviews. :72-93
Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various
Autor:
Nicholas von Guionneau, Sami H. Tuffaha, Hai-Quan Mao, Michael J. Lan, Gregory P. Howard, Sashank Reddy, Karim A. Sarhane, Thomas G.W. Harris, Jennifer Rath, Chenhu Qiu, Harsha Malapati, Philip J. Hanwright, Yang Zhou, Ahmet Hoke
Publikováno v:
Biomaterials. 280
Functional recovery following peripheral nerve injury is limited by progressive atrophy of denervated muscle and Schwann cells (SCs) that occurs during the long regenerative period prior to end-organ reinnervation. Insulin-like growth factor 1 (IGF-1
Autor:
Kuntao Chen, Caleb F. Anderson, Jung Hee Seo, Hai-Quan Mao, Rajat Mittal, Martin G. Pomper, Il Minn, Hye Hyun Ahn, Yizong Hu, Zhiyu He, Like Gong, Xiyu Ke, Marion Pang, Yue Hao, Gregory P. Howard, Heng Wen Liu, Christine A. Carrington, Mary Brummet, Christopher G. Ullman, Honggang Cui, Jinchang Zhu
Publikováno v:
ACS Nano
Polyelectrolyte complex (PEC) nanoparticles assembled from plasmid DNA (pDNA) and polycations such as linear polyethyleneimine (lPEI) represent a major non-viral delivery vehicle for gene therapy tested thus far. Efforts to control the size, shape an
Autor:
Victoria K. Baxter, Timothy Hamerly, Garima Verma, Rhoel R. Dinglasan, Hai-Quan Mao, Gregory P. Howard, Winter M. Thayer, John E. Lee, Xiyu Ke
Publikováno v:
Nano Res
Lymph node (LN) targeting through interstitial drainage of nanoparticles (NPs) is an attractive strategy to stimulate a potent immune response, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an
Publikováno v:
Biomaterials Science. 7:4873-4887
To overcome the immunosuppressive milieu of malignancy and lack of well-defined antigens, potent adjuvants are needed for cancer immunotherapy. Numerous small molecular immunomodulators have the potential to fulfill this role. To enhance the immune r