Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gregory P. Howard"'
Autor:
Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, Brianna N Smith, Macey J Slota, Elizabeth M Reynolds, Soumita Goswami, Michael R Savona, Frank M Mason, Taekyu Lee, Stephen Fesik, Qi Liu, William P Tansey
Publikováno v:
eLife, Vol 12 (2024)
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site that tethers WDR5 to chromatin. WIN site inhibi
Externí odkaz:
https://doaj.org/article/843d9e309e8c4e569cdd20374b77da61
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 ha
Externí odkaz:
https://doaj.org/article/4970649d70db445fb70eaa8e823937b6
Akademický článek
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Autor:
Gregory P. Howard, Nicole G. Bender, Prachi Khare, Borja López-Gutiérrez, Vincent Nyasembe, William J. Weiss, Jerry W. Simecka, Timothy Hamerly, Hai-Quan Mao, Rhoel R. Dinglasan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A successful malaria transmission blocking vaccine (TBV) requires the induction of a high antibody titer that leads to abrogation of parasite traversal of the mosquito midgut following ingestion of an infectious bloodmeal, thereby blocking the cascad
Externí odkaz:
https://doaj.org/article/b57a063ffd7d4e87aa007842f02ce0da
Autor:
April M. Weissmiller, Jing Wang, Shelly L. Lorey, Gregory C. Howard, Ernest Martinez, Qi Liu, William P. Tansey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
SMARCB1/SNF5 is a tumour suppressor and component of the SWI/SNF chromatin remodeler. Here the authors show that, independent of chromatin remodelling activities, SNF5 acts to inhibit the pro-tumorigenic transcriptional program of MYC via control of
Externí odkaz:
https://doaj.org/article/13320eef54514e9293ebfcb6fc8bf6ca
Autor:
Tessa M Popay, Jing Wang, Clare M Adams, Gregory Caleb Howard, Simona G Codreanu, Stacy D Sherrod, John A McLean, Lance R Thomas, Shelly L Lorey, Yuichi J Machida, April M Weissmiller, Christine M Eischen, Qi Liu, William P Tansey
Publikováno v:
eLife, Vol 10 (2021)
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to
Externí odkaz:
https://doaj.org/article/858ae447047d4222bb272f96fbb33a0c
Autor:
Erin R. Aho, Jing Wang, Rocco D. Gogliotti, Gregory C. Howard, Jason Phan, Pankaj Acharya, Jonathan D. Macdonald, Ken Cheng, Shelly L. Lorey, Bin Lu, Sabine Wenzel, Audra M. Foshage, Joseph Alvarado, Feng Wang, J. Grace Shaw, Bin Zhao, April M. Weissmiller, Lance R. Thomas, Christopher R. Vakoc, Matthew D. Hall, Scott W. Hiebert, Qi Liu, Shaun R. Stauffer, Stephen W. Fesik, William P. Tansey
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2916-2928.e13 (2019)
Summary: The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the “WIN site” of WDR5, a well-defined pocket that is amenable to small molecule inhib
Externí odkaz:
https://doaj.org/article/624392b24e9c465daac627e90b1195e5
Autor:
Kirsty L. Wilson, Gregory P. Howard, Heather Coatsworth, Rhoel R. Dinglasan, Hai-Quan Mao, Magdalena Plebanski
Publikováno v:
Vaccines, Vol 8, Iss 2, p 261 (2020)
Sustained immune responses, particularly antibody responses, are key for protection against many endemic infectious diseases. Antibody responses are often accompanied by T helper (Th) cell immunity. Herein we study small biodegradable poly (ethylene
Externí odkaz:
https://doaj.org/article/3c9af4c385324c2a82760accc28d0730
Autor:
Tianqi Nie, Lixin Liu, Zhiyu He, Jinchang Zhu, Il Minn, Jesus Pacheco-Torres, Kuntao Chen, Pengfei Zhao, Gregory P. Howard, Hai-Quan Mao, Yongming Chen, Zaver M. Bhujwalla
Publikováno v:
Nano Research. 14:2749-2761
Levodopa (L-DOPA), a precursor of dopamine, is commonly prescribed for the treatment of the Parkinson’s disease (PD). However, oral administration of levodopa results in a high level of homocysteine in the peripheral circulation, thereby elevating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf3a51874346d20c93d00a30719ec844
https://doi.org/10.1007/s12274-020-3280-0
https://doi.org/10.1007/s12274-020-3280-0
Autor:
Nicholas von Guionneau, Sami H. Tuffaha, Hai-Quan Mao, Michael J. Lan, Gregory P. Howard, Sashank Reddy, Karim A. Sarhane, Thomas G.W. Harris, Jennifer Rath, Chenhu Qiu, Harsha Malapati, Philip J. Hanwright, Yang Zhou, Ahmet Hoke
Publikováno v:
Biomaterials. 280
Functional recovery following peripheral nerve injury is limited by progressive atrophy of denervated muscle and Schwann cells (SCs) that occurs during the long regenerative period prior to end-organ reinnervation. Insulin-like growth factor 1 (IGF-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f0a8368d77aff2c8192cfb6a294074
https://pubmed.ncbi.nlm.nih.gov/34794826
https://pubmed.ncbi.nlm.nih.gov/34794826