Pharmacokinetic modeling of dynamic contrast-enhanced (DCE)-MRI in PI-RADS category 3 peripheral zone lesions: preliminary study evaluating DCE-MRI as an imaging biomarker for detection of clinically significant prostate cancers

Autor: Christopher S. Lim, Jorge Abreu-Gomez, Gregory O. Cron, Nima Sadoughi, Nicola Schieda, Satheesh Krishna

Publikováno v: Abdominal radiology (New York). 46(9)

To determine if pharmacokinetic modeling of DCE-MRI can diagnose CS-PCa in PI-RADS category 3 PZ lesions with subjective negative DCE-MRI.In the present IRB approved, bi-institutional, retrospective, case-control study, we identified 73 men with 73 P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a277f16ded0a303fc45a4207968aedfa
https://pubmed.ncbi.nlm.nih.gov/33818626

Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice

Autor: Gregory O. Cron, Luciano da Fontoura Costa, Alex Gutsol, Cesar H. Comin, Christopher R.J. Kennedy, Douglas A. Gray, Anthony Carter, Richard L. Hébert, Naomi C. Boisvert, Chet E. Holterman, Jean-Francois Thibodeau, Eldjonai Kamto, Baptiste Lacoste, Rania Nasrallah

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. Uchl1 deletion in mice leads to progressive axonal degeneration, affecting the dorsal root gan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353aa4016459f258135965327f1f2b91
https://pubmed.ncbi.nlm.nih.gov/29739827

Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using F19 MRI

Autor: Gregory O. Cron, Bénédicte F. Jordan, Julie Magat, Bernard Gallez

Publikováno v: Medical Physics. 37:5434-5441

PURPOSE: Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and may be a poorly appreciated therapeutic problem as it can be associated with resistance to radiation therapy, impaired delivery of chemotherapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b128ff4f3bd80f8833ff8f141ed96c0
https://doi.org/10.1118/1.3484056

Determination of the maturity and functionality of tumor vasculature by MRI: Correlation between BOLD-MRI and DCE-MRI using P792 in experimental fibrosarcoma tumors

Autor: Bernard Gallez, Gregory O. Cron, Christine Baudelet

Publikováno v: Magnetic Resonance in Medicine. 56:1041-1049

Using hypercapnia and carbogen as functional markers of vessel maturation and function, we compared blood oxygen level-dependent (BOLD) contrast with standard dynamic contrast-enhanced (DCE)-MRI quantitative parameters in murine fibrosarcoma. Our res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76576a813c42f1afe84be296edd57bd8
https://doi.org/10.1002/mrm.21047

Tumor Radiosensitization by Antiinflammatory Drugs: Evidence for a New Mechanism Involving the Oxygen Effect

Autor: Nathalie Crokart, Bénédicte F. Jordan, Gregory O. Cron, Olivier Feron, Kim Radermacher, Bernard Gallez, Vincent Grégoire, Caroline Bouzin, Christine Baudelet, Nelson Beghein

Publikováno v: DIAL
Cancer Research, Vol. 65, no. 17, p. 7911-7916 (2005)

We hypothesized that nonsteroidal antiinflammatory drugs (NSAIDs) might enhance tumor radiosensitivity by increasing tumor oxygenation (pO2), via either a decrease in the recruitment of macrophages or from inhibition of mitochondrial respiration. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0499f4e45590243917fb3ad525317c1
https://doi.org/10.1158/0008-5472.can-05-1288