Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gregory N Hunt"'
Autor:
Joseph B. Moore, Gregory N. Hunt, Anna M. Gumpert, Marcin Wysoczynski, Yibing Nong, Qianhong Li, Xiaoping Zhu, Michael Book, Alex Tomlin, Wen-Jian Wu, Xian-Liang Tang, Senthilkumar K. Muthusamy, Abdur Rahman Khan, Roberto Bolli, Hong Li, Yiru Guo, Marjan Nasr
Publikováno v:
Journal of the American College of Cardiology. 69:1824-1838
Background The authors previously reported that the c-kit–positive (c-kitPOS) cells isolated from slowly adhering (SA) but not from rapidly adhering (RA) fractions of cardiac mesenchymal cells (CMCs) are effective in preserving left ventricular (LV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad680a8c76e37cbc2bc2938f5991a9bd
https://doi.org/10.1016/j.jacc.2017.01.048
https://doi.org/10.1016/j.jacc.2017.01.048
Autor:
Gregory N. Hunt, Gregg Shirk, Roberto Bolli, Yukichi Tokita, Gregg Rokosh, Buddhadeb Dawn, Matthew C.L. Keith, Heather Stowers, Santosh K. Sanganalmath, Wen-Jian Wu, Xian Liang Tang
Publikováno v:
Circulation: Heart Failure. 8:757-765
Background— Although c-kit pos cardiac stem cells (CSCs) preserve left ventricular (LV) function and structure after myocardial infarction, CSC doses have been chosen arbitrarily, and the dose–effect relationship is unknown. Methods and Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec5142f377516a6c778009cb292dd84
https://doi.org/10.1161/circheartfailure.115.002210
https://doi.org/10.1161/circheartfailure.115.002210
Autor:
Qianhong Li, Charles Steenbergen, Xiaoping Zhu, Ramzi A Ockaili, Shashi Bhushan, Kazuhisa Kondo, Steven P. Jones, Rakesh C. Kukreja, Adam Orr, Gregory N. Hunt, David J. Lefer, Yibing Nong, Yiru Guo, Xian Liang Tang, Carlos C. Chang, Fadi N Salloum, Heather Stowers, Junjie Du, Roberto Bolli, Traci T. Goodchild, Maiying Kong
Publikováno v:
Circulation Research. 116:572-586
Rationale: Despite 4 decades of intense effort and substantial financial investment, the cardioprotection field has failed to deliver a single drug that effectively reduces myocardial infarct size in patients. A major reason is insufficient rigor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0b77e67c1ae064adb9e0d589b595d1
https://doi.org/10.1161/circresaha.116.305462
https://doi.org/10.1161/circresaha.116.305462
Autor:
Xiaoping Zhu, Fangping Yuan, Qianhong Li, Gregory N. Hunt, Roberto Bolli, Qinghui Ou, Wen Jian Wu, Buddhadeb Dawn, Wei Tan, Li Luo, Ning Chen, Yiru Guo
Publikováno v:
Basic Research in Cardiology. 106:1367-1377
Extensive evidence indicates that heme oxygenase-1 (HO-1) exerts potent cytoprotective effects in response to stress. Previous studies have shown that gene therapy with HO-1 protects against myocardial ischemia/reperfusion injury for up to 8 weeks af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfd4ade59e2267739e68537a6edd54d
https://doi.org/10.1007/s00395-011-0208-6
https://doi.org/10.1007/s00395-011-0208-6
Autor:
Ning Chen, Qianhong Li, Yiru Guo, Erin O'Brien, Fangping Yuan, Qinghui Ou, Xiaoping Zhu, Wen Jian Wu, Gregory N. Hunt, Li Luo, Tao Wang, Roberto Bolli
Publikováno v:
Basic Research in Cardiology. 106:849-864
A model of intracoronary stem cell delivery that enables transgenesis/gene targeting would be a powerful tool but is still lacking. To address this gap, we compared intracoronary and intramyocardial delivery of lin(-)/c-kit(+)/GFP(+) cardiac stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2f951fef8c78f16b709cdc6524b6c9
https://doi.org/10.1007/s00395-011-0180-1
https://doi.org/10.1007/s00395-011-0180-1
Autor:
Qianhong Li, Ning Chen, Li Luo, Qinghui Ou, Wei Xie, Gregory N Hunt, Xian-Liang Tang, Gregg D Rokosh, Roberto Bolli
Publikováno v:
Circulation. 130
Background: We have previously shown in rats that the beneficial effects of c-kit + CSCs on LV function and remodeling post-myocardial infarction persist for at least 1 year after CSC administration. However, in that study the retention of transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::127ff6291ed2c40417e9edd191b08d93
https://doi.org/10.1161/circ.130.suppl_2.15555
https://doi.org/10.1161/circ.130.suppl_2.15555
Autor:
David J. Lefer, Steven P. Jones, Kazuhisa Kondo, Gregory N. Hunt, Yiru Guo, Maiying Kong, Qianhong Li, Charles Steenbergen, Adam Orr, Rakesh C. Kukreja, Carlos C. Chang, Fadi N Salloum, Ramzi A Ockaili, Traci T. Goodchild, Heather Stowers, Xian-Liang Tang, Roberto Bolli, Shashi Bhushan
Publikováno v:
The FASEB Journal. 28
Despite decades of effort and staggering financial support, the cardioprotection field failed to deliver a drug that effectively reduces infarct size in patients. To address the limitations to such...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b19fc9bc2a79b1f76d013ab91aa68f9
https://doi.org/10.1096/fasebj.28.1_supplement.lb698
https://doi.org/10.1096/fasebj.28.1_supplement.lb698
Autor:
Qianhong Li, Traci T. Goodchild, Junjie Du, Steven P. Jones, Xian-Liang Tang, Fadi N Salloum, Rakesh C. Kukreja, Charles Steenbergen, Gregory N. Hunt, Wen-Jian Wu, David J. Lefer, Michael Book, Roberto Bolli, Maiying Kong, Ramzi A Ockaili, Yukichi Tokita, Yiru Guo, Heather Stowers, Carlos C. Chang, Shashi Bhushan
Publikováno v:
The FASEB Journal. 28
Prior studies have shown cardioprotective effects of the phosphodiesterase-5 inhibitor, sildenafil, in the setting of myocardial ischemia and reperfusion (MI/R) in mice and rabbits. To verify these...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad328a8a8c051022a6e7f6af418fee3
https://doi.org/10.1096/fasebj.28.1_supplement.lb650
https://doi.org/10.1096/fasebj.28.1_supplement.lb650
Autor:
Kyung U. Hong, Michael P. Flaherty, Gregory N. Hunt, Brian L. Ganzel, Marcin Wysoczynski, Xian Liang Tang, Yukichi Tokita, Roberto Bolli, Qian Hong Li, Joseph B. Moore, Kendra J. Grubb, Brandon J Elmore, Matthew C.L. Keith, Bathri N Vajravelu, Shahab Ghafghazi, Alok R. Amraotkar
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124227 (2015)
PLoS ONE
PLoS ONE
Background There is mounting interest in using c-kit positive human cardiac stem cells (c-kitpos hCSCs) to repair infarcted myocardium in patients with ischemic cardiomyopathy. A recent phase I clinical trial (SCIPIO) has shown that intracoronary inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4ef8830274eb860b596235b6a61ab7
https://doi.org/10.1371/journal.pone.0124227
https://doi.org/10.1371/journal.pone.0124227
Autor:
Heather Stowers, Gregg Rokosh, Xian-Liang Tang, Gregg Shirk, Santosh K. Sanganalmath, Gregory N. Hunt, Buddhadeb Dawn, Roberto Bolli
Publikováno v:
Journal of the American College of Cardiology. (10):A961
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7822b6111dba45fb7da13fb3090e6a9