Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Gregory M.K. Poon"'
Autor:
J. Ross Terrell, Samuel J. Taylor, Amelia L. Schneider, Yue Lu, Tyler N. Vernon, Suela Xhani, Ryan H. Gumpper, Ming Luo, W. David Wilson, Ulrich Steidl, Gregory M.K. Poon
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112671- (2023)
Summary: The master transcriptional regulator PU.1/Spi-1 engages DNA sites with affinities spanning multiple orders of magnitude. To elucidate this remarkable plasticity, we have characterized 22 high-resolution co-crystallographic PU.1/DNA complexes
Externí odkaz:
https://doaj.org/article/3a08b530979c4b649e48bbf830396248
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5393-5400 (2022)
Exposure to ultraviolet (UV) light causes the formation of mutagenic cyclobutane pyrimidine dimers (CPDs) in cellular DNA. Previous studies have revealed that CPD formation in nucleosomes, the building blocks of chromatin, shows a striking ∼10 base
Externí odkaz:
https://doaj.org/article/1f2880eb5ab94929ac60e481f9bf3fbd
Publikováno v:
Applied Measurement in Education. 36:80-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e827db2f96873a5eaab48e20bcc50e82
https://doi.org/10.1080/08957347.2023.2172017
https://doi.org/10.1080/08957347.2023.2172017
Publikováno v:
Phys Chem Chem Phys
Electrostatic protein/DNA interactions arise from the neutralization of the DNA phosphodiester backbone as well as coupled exchanges by charged protein residues as salt bridges or with mobile ions. Much focus has been and continues to be paid to inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543b23095167e26afb138b78cdf38c5d
https://doi.org/10.1039/d1cp01568k
https://doi.org/10.1039/d1cp01568k
Autor:
Noa Erlitzki, Gregory M.K. Poon, Abdelbasset A. Farahat, Van L.T. Ha, Arvind Kumar, David W. Boykin
Publikováno v:
Biophys J
Sequence selectivity is a critical attribute of DNA-binding ligands and underlines the need for detailed molecular descriptions of binding in representative sequence contexts. We investigated the binding and volumetric properties of DB1976, a model b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f080abf9987b9dc8067c8d078488f1
https://doi.org/10.1016/j.bpj.2020.08.013
https://doi.org/10.1016/j.bpj.2020.08.013
Publikováno v:
Biochimie
Hairpin polyamides are synthetic small molecules that bind DNA minor groove sequence-selectively and, in many sequences, induce widening of the minor groove and compression of the major groove. The structural distortion of DNA caused by polyamides ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27533a8a4702ac092c45269a305db86a
https://doi.org/10.1016/j.biochi.2019.08.009
https://doi.org/10.1016/j.biochi.2019.08.009
Autor:
Smitha Sivapragasam, Mingrui Duan, Gregory M.K. Poon, Jacob S. Antony, John J. Wyrick, John M. Hinz, Jenna Ulibarri, Peng Mao
DNA base damage arises frequently in living cells and needs to be removed by base excision repair (BER) to prevent mutagenesis and genome instability. Both the formation and repair of base damage occur in chromatin and are conceivably affected by DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a2673bf9b0b94a24dce873dc11a2de
https://doi.org/10.1101/2021.09.24.461700
https://doi.org/10.1101/2021.09.24.461700
Autor:
Patrick J. Hrdlicka, Steven A. Roberts, Amanda V. Albrecht, Peng Mao, Raymond G Emehiser, Bastian Stark, Kaitlynne A. Bohm, John J. Wyrick, Smitha Sivapragasam, Gregory M.K. Poon
Publikováno v:
EMBO J
Somatic mutations in DNA-binding sites for CCCTC-binding factor (CTCF) are significantly elevated in many cancers. Prior analysis has suggested that elevated mutation rates at CTCF-binding sites in skin cancers are a consequence of the CTCF-cohesin c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a377e6031955e2e8ead4c1faadc6c301
https://doi.org/10.15252/embj.2021107795
https://doi.org/10.15252/embj.2021107795
Publikováno v:
J Biol Chem
Functional evidence increasingly implicates low-affinity DNA recognition by transcription factors as a general mechanism for the spatiotemporal control of developmental genes. Although the DNA sequence requirements for affinity are well-defined, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9a1d8484ace078536c59a62c842e7b
https://doi.org/10.1074/jbc.ra119.007866
https://doi.org/10.1074/jbc.ra119.007866
Autor:
Michael Stürzl, Christian Beyer, Christiane Maier, Simon Rauber, Andreas Ramming, Falk Butter, Astrid Jüngel, Arif B. Ekici, Jörg H W Distler, Clara Dees, Steffen Uebe, Christoph Daniel, Stephen L. Nutt, Stefanie Weber, Michael Sticherling, Hans P. Kiener, Kolja Gelse, Georg Schett, Emmanuel Karouzakis, Susetta Finotto, E. Pachera, David W. Boykin, Alexandru-Emil Matei, Mark H. Kaplan, Andreas E. Kremer, Alina Soare, Elisabeth Naschberger, Oliver Distler, Gregory M.K. Poon, Markus Luber, Chih-Wei Chen, Alexander Kreuter, Thomas Wohlfahrt
Publikováno v:
Nature
Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3525228a2dbf2fe6b17117fd7441a0
https://doi.org/10.1038/s41586-019-0896-x
https://doi.org/10.1038/s41586-019-0896-x