Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gregory M. Vath"'
Autor:
Edith Sim, Gregory M. Vath, Carston R. Wagner, Haiqing Wang, Akane Kawamura, Patrick E. Hanna, Caleb A. Bates
Publikováno v:
The Protein Journal. 24:65-77
Human arylamine N-acetyltransferase 1 (NAT1) has been overexpressed in E. coli as a mutant dihydrofolic acid reductase (DHFR) fusion protein with a thrombin sensitive linker. An initial DEAE anion-exchange chromatography resulted in partial purificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fa9a445ee6555b00343c6a384f5a06
https://doi.org/10.1007/s10930-004-1513-9
https://doi.org/10.1007/s10930-004-1513-9
Autor:
Carston R. Wagner, Patrick E. Hanna, Akane Kawamura, Edith Sim, Gregory M. Vath, Adeel Mushtaq, Stefanos A. Tsiftsoglou, James E. Graham
Publikováno v:
Biochemical Pharmacology. 69:347-359
Arylamine N-acetyltransferases (NAT; EC 2.3.1.5) catalyse the transfer of acetyl groups from acetylCoA to xenobiotics, including drugs and carcinogens. The enzyme is found extensively in both eukaryotes and prokaryotes, yet the endogenous roles of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fe1cad560b41e77688fff242ff23d35
https://doi.org/10.1016/j.bcp.2004.09.014
https://doi.org/10.1016/j.bcp.2004.09.014
Publikováno v:
Biochemistry. 43:8234-8246
Arylamine N-acetyltransferases (NATs) catalyze an acetyl group transfer from acetyl coenzyme A (AcCoA) to arylamines, hydrazines, and their N-hydroxylated arylamine metabolites. The recently determined three-dimensional structures of prokaryotic NATs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8297768f99859bf4e76164a74a61ab
https://doi.org/10.1021/bi0497244
https://doi.org/10.1021/bi0497244
Publikováno v:
The Protein Journal. 23:153-166
Arylamine N-acetyltransferases (NATs) catalyze a variety of biotransformation reactions, including N-acetylation of arylamines and O-acetylation of arylhydroxylamines. Chemical modification of hamster recombinant NAT2 with 2-(bromoacetylamino)fluoren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a459cf2f96b622d570e98a57532ed116
https://doi.org/10.1023/b:jopc.0000020082.14480.e2
https://doi.org/10.1023/b:jopc.0000020082.14480.e2
Autor:
Steven R. Monday, Gregory M. Vath, Witold A. Ferens, Claudia Deobald, James V. Rago, Pamala J. Gahr, Dileep D. Monie, John J. Iandolo, Stephen K. Chapes, William C. Davis, Douglas H. Ohlendorf, Patrick M. Schlievert, Gregory A. Bohach
Publikováno v:
The Journal of Immunology. 162:4550-4559
Certain strains of Staphylococcus aureus express one or both of two related, but immunologically distinct, exfoliative toxins (ETA and ETB). These toxins induce the symptoms associated with staphylococcal scalded skin syndrome. Both ETs have been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c350ae6b6c96328bfe40f403731f81c2
https://doi.org/10.4049/jimmunol.162.8.4550
https://doi.org/10.4049/jimmunol.162.8.4550
Autor:
Cathleen A. Earhart, Michael H Kim, Patrick M. Schlievert, Gregory M. Vath, Douglas H. Ohlendorf, Gregory A. Bohach, James V. Rago
Publikováno v:
Biochemistry. 36:1559-1566
Exfoliative toxin A (ETA) causes staphylococcal scalded skin syndrome which is characterized by a specific intraepidermal separation of layers of the skin. The mechanism by which ETA causes skin separation is unknown although protease or superantigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a254c6a4b9140051dfd229ba6cacffd0
https://doi.org/10.1021/bi962614f
https://doi.org/10.1021/bi962614f
Autor:
Akane, Kawamura, James, Graham, Adeel, Mushtaq, Stefanos A, Tsiftsoglou, Gregory M, Vath, Patrick E, Hanna, Carston R, Wagner, Edith, Sim
Publikováno v:
Biochemical pharmacology. 69(2)
Arylamine N-acetyltransferases (NAT; EC 2.3.1.5) catalyse the transfer of acetyl groups from acetylCoA to xenobiotics, including drugs and carcinogens. The enzyme is found extensively in both eukaryotes and prokaryotes, yet the endogenous roles of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f5dac10ad7c2a335d65a224a6bce18b
https://pubmed.ncbi.nlm.nih.gov/15627487
https://pubmed.ncbi.nlm.nih.gov/15627487
Publikováno v:
Journal of protein chemistry. 22(7-8)
Kinetic analysis of the inactiviation of hamster NAT1 by 2-(bromoacetylamino)fluorene (Br-AAF) and bromoacetanilide revealed that Br-AAF is an active site directed affinity label whereas bromoacetanilide acts as a bimolecular alkylating agent. ESI MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4460659025fed99b1a1761a1dd6b1a03
https://pubmed.ncbi.nlm.nih.gov/14714730
https://pubmed.ncbi.nlm.nih.gov/14714730
Autor:
Gregory M. Vath, Patrick M. Schlievert, Manuela Roggiani, Cathleen A. Earhart, Douglas H. Ohlendorf
The streptococcal pyrogenic toxins A, B, and C (SPEA, SPEB, and SPEC) are responsible for the fever, rash, and other toxicities associated with scarlet fever and streptococcal toxic shock syndrome. This role, together with the ubiquity of diseases ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b82c15d8a6ccc598388e78f9db63a57
https://europepmc.org/articles/PMC2144691/
https://europepmc.org/articles/PMC2144691/
Autor:
Gregory M. Vath, Gregory A. Bohach, Timothy J. Tripp, Patrick M. Schlievert, James V. Rago, Douglas H. Ohlendorf
Publikováno v:
Infection and immunity. 68(4)
The staphylococcal exfoliative toxins (ETs) A and B (ETA and ETB) are 27-kDa exotoxins produced by certain strains ofStaphylococcus aureusand are the causative agents of staphylococcal scalded-skin syndrome. The crystal structures of the ETs strongly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae8517641feb42702373370332bf245
https://pubmed.ncbi.nlm.nih.gov/10722646
https://pubmed.ncbi.nlm.nih.gov/10722646