Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gregory M. Solis"'
Autor:
Gregory M Solis, Rozina Kardakaris, Elizabeth R Valentine, Liron Bar-Peled, Alice L Chen, Megan M Blewett, Mark A McCormick, James R Williamson, Brian Kennedy, Benjamin F Cravatt, Michael Petrascheck
Publikováno v:
eLife, Vol 7 (2018)
Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficie
Externí odkaz:
https://doaj.org/article/8d48aceb33a9430d85b333a85f0d70bb
Autor:
Sunitha Rangaraju, Gregory M Solis, Ryan C Thompson, Rafael L Gomez-Amaro, Leo Kurian, Sandra E Encalada, Alexander B Niculescu III, Daniel R Salomon, Michael Petrascheck
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/234bd8b1a58145ef96abed50af71864b
Autor:
Sunitha Rangaraju, Gregory M Solis, Ryan C Thompson, Rafael L Gomez-Amaro, Leo Kurian, Sandra E Encalada, Alexander B Niculescu III, Daniel R Salomon, Michael Petrascheck
Publikováno v:
eLife, Vol 4 (2015)
Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes t
Externí odkaz:
https://doaj.org/article/b5070be77ddd4d03af090ba4cac90291
Autor:
Michael Petrascheck, Maria Carretero, Veronika Peterka, Alan To, Olivia Osborn, Natalie Weber, Anabel Pérez-Gómez, Viktoriya Titova, Gregory M. Solis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications
Nature communications, vol 9, iss 1
Antipsychotic (AP) drugs are used to treat psychiatric disorders but are associated with significant weight gain and metabolic disease. Increased food intake (hyperphagia) appears to be a driving force by which APs induce weight gain but the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dafb66861c556cc3090537708d94e05
https://doi.org/10.1038/s41467-018-07684-y
https://doi.org/10.1038/s41467-018-07684-y
Autor:
Michael Petrascheck, Gregory M. Solis, Elizabeth R Valentine, Alice L Chen, Megan M. Blewett, James R. Williamson, Brian K. Kennedy, Liron Bar-Peled, Mark A. McCormick, Benjamin F. Cravatt, Rozina Kardakaris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48d3ce574b2d066a8aae8590c0507a20
https://doi.org/10.7554/elife.40314.023
https://doi.org/10.7554/elife.40314.023
Autor:
Michael Petrascheck, Liron Bar-Peled, Brian K. Kennedy, Elizabeth R Valentine, Rozina Kardakaris, Megan M. Blewett, Gregory M. Solis, Mark A. McCormick, Alice L Chen, Benjamin F. Cravatt, James R. Williamson
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa0a8205f08f8da5f67d4bbc8de8e41
https://pubmed.ncbi.nlm.nih.gov/30479271
https://pubmed.ncbi.nlm.nih.gov/30479271
Autor:
Benjamin F. Cravatt, Elizabeth R Valentine, Liron Bar-Peled, Michael Petrascheck, Mark A. McCormick, Alice L Chen, Megan M. Blewett, Rozina Kardakaris, Gregory M. Solis, Brian K. Kennedy, James R. Williamson
SummaryAging impairs the activation of Stress Signaling Pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5307af6399385c3c28f7c1f4d5605b
Autor:
Gregory M. Solis, Rafael L. Gomez-Amaro, Caroline D. Broaddus, Rozina Kardakaris, Alexander B. Niculescu, Sofia I. Andersson, Michael Petrascheck, Sunitha Rangaraju
Publikováno v:
Aging Cell
Summary Oxidative stress has long been associated with aging and has recently been linked to psychiatric disorders, including psychosis and depression. We identified multiple antipsychotics and antidepressants that extend Caenorhabditis elegans lifes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480fadfa047a66b6a290bed5b27560a0
https://doi.org/10.1111/acel.12379
https://doi.org/10.1111/acel.12379
Autor:
Gregory M. Solis, Rafael L. Gomez-Amaro, Michael Petrascheck, Elizabeth R Valentine, Caroline D. Broaddus, James R. Williamson, Sunitha Rangaraju, Sarah E. LeBoeuf, Maria Carretero
Publikováno v:
Genetics
Caenorhabditis elegans has emerged as a powerful model to study the genetics of feeding, food-related behaviors, and metabolism. Despite the many advantages of C. elegans as a model organism, direct measurement of its bacterial food intake remains ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcc82719719eae64742cecf18bbe490
https://doi.org/10.1534/genetics.115.175851
https://doi.org/10.1534/genetics.115.175851
Autor:
Irit Rappley, R. Luke Wiseman, Mathew S. Maurer, Teresa Coelho, Gregory M. Solis, Evan T. Powers, Marta Novais, Jeffery W. Kelly, Aleksandra Baranczak, Cecília Monteiro, Stephen Helmke
Publikováno v:
Biochemistry
The transthyretin (TTR) amyloidoses are a group of degenerative diseases caused by TTR aggregation, requiring rate-limiting tetramer dissociation. Kinetic stabilization of TTR, by preferential binding of a drug to the native tetramer over the dissoci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980fbd673f13c1080928504312f0caf5
https://doi.org/10.1021/bi500171j
https://doi.org/10.1021/bi500171j