Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Gregory M. Shackleford"'
Autor:
Hung N. Tran, Hardeep P. Singh, Wenxuan Guo, Linda Cambier, Luke Riggan, Gregory M. Shackleford, Matthew E. Thornton, Brendan H. Grubbs, Anat Erdreich-Epstein, Dong-Lai Qi, David Cobrinik
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
MYC family oncoproteins MYC, MYCN, and MYCL are deregulated in diverse cancers and via diverse mechanisms. Recent studies established a novel form of MYCN regulation in MYCN-overexpressing retinoblastoma and neuroblastoma cells in which the MDM2 onco
Externí odkaz:
https://doaj.org/article/d6ca264ad7c445e7ba947fbc67f0ea3f
Autor:
Jingying Xu, Xiuhai Ren, Anup Singh Pathania, G. Esteban Fernandez, Anthony Tran, Yifu Zhang, Rex A. Moats, Gregory M. Shackleford, Anat Erdreich-Epstein
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Phosphotyrosine Interaction Domain containing 1 (PID1; NYGGF4) inhibits growth of medulloblastoma, glioblastoma and atypical teratoid rhabdoid tumor cell lines. PID1 tumor mRNA levels are highly correlated with longer survival in medulloblas
Externí odkaz:
https://doaj.org/article/92bd243d604b4943937fb2dd4306225e
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file 92K, Supplemental Fig 5: Expression of PID1 protein in human brain tumors and cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82bea2b8c767c454086e43a6cb428cd
https://doi.org/10.1158/1078-0432.22449965
https://doi.org/10.1158/1078-0432.22449965
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 190K, Supplemental Fig 2: Proneural and Neural GBMs have higher PID1 mRNA; higher PID1 mRNA correlates with higher OS in patients with gliomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc273645c3c2cb62aa3119bfff91078
https://doi.org/10.1158/1078-0432.22449974.v1
https://doi.org/10.1158/1078-0432.22449974.v1
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 159K, Supplemental Fig 1: PID1 mRNA is lower in less favorable medulloblastomas in two additional independent datasets; PID1 mRNA correlates with rf-PFS when analyzing CHLA medulloblastomas by tertiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc3d85666d5ca39bff7ed5663e6d04d
https://doi.org/10.1158/1078-0432.22449977.v1
https://doi.org/10.1158/1078-0432.22449977.v1
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 17K, Supplemental Fig 4: PID1 increases the proportion of cells in Sub G0/G1 in CHLA-259 medulloblastoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61093f972bcf75092590c405fa1c3215
https://doi.org/10.1158/1078-0432.22449968
https://doi.org/10.1158/1078-0432.22449968
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
Purpose: We present here the first report of PID1 (Phosphotyrosine Interaction Domain containing 1; NYGGF4) in cancer. PID1 was identified in 2006 as a gene that modulates insulin signaling and mitochondrial function in adipocytes and muscle cells.Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c143c3c543fc8e4407e7c83c12e25822
https://doi.org/10.1158/1078-0432.c.6521810
https://doi.org/10.1158/1078-0432.c.6521810
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 440K, Supplemental Table 1: Characteristics of the CHLA Medulloblastoma Patients. Supplemental Table 2: Neural and Proneural GBM subgroups have higher PID1 mRNA compared to Classical and Mesenchymal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a79da4827af21a1d7b7b3d6849de249
https://doi.org/10.1158/1078-0432.22449959.v1
https://doi.org/10.1158/1078-0432.22449959.v1
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 42K, Supplemental Fig 3: PID1 also inhibits colony formation using two other plasmid expression vectors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f613692d8ddcc5598abc847cc41b84
https://doi.org/10.1158/1078-0432.22449971.v1
https://doi.org/10.1158/1078-0432.22449971.v1
Autor:
Paul S. Mischel, Charles L. Sawyers, Timothy F. Cloughesy, Ingo K. Mellinghoff, Webster K. Cavenee, Gregory M. Shackleford, Igor Vivanco, Ederlyn Q. Dia, Shaojun Zhu, Kan V. Lu, Maria Y. Wang
The epidermal growth factor receptor (EGFR) is commonly amplified, overexpressed, and mutated in glioblastoma, making it a compelling molecular target for therapy. We have recently shown that coexpression of EGFRvIII and PTEN protein by glioblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5c233e960ac5ff0bc859d5d77d3cae
https://doi.org/10.1158/0008-5472.c.6494484.v1
https://doi.org/10.1158/0008-5472.c.6494484.v1