Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gregory M. Goldgof"'
Autor:
Sabine Ottilie, Madeline R. Luth, Erich Hellemann, Gregory M. Goldgof, Eddy Vigil, Prianka Kumar, Andrea L. Cheung, Miranda Song, Karla P. Godinez-Macias, Krypton Carolino, Jennifer Yang, Gisel Lopez, Matthew Abraham, Maureen Tarsio, Emmanuelle LeBlanc, Luke Whitesell, Jake Schenken, Felicia Gunawan, Reysha Patel, Joshua Smith, Melissa S. Love, Roy M. Williams, Case W. McNamara, William H. Gerwick, Trey Ideker, Yo Suzuki, Dyann F. Wirth, Amanda K. Lukens, Patricia M. Kane, Leah E. Cowen, Jacob D. Durrant, Elizabeth A. Winzeler
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Ottilie et al. employ an experimental evolution approach to investigate the role of transcription factors in yeast chemical resistance. Most emergent mutations in resistant strains were enriched in transcription factor coding genes, highlighting thei
Externí odkaz:
https://doaj.org/article/9094da31e4444ec8861d9e3850fe0c08
Discovery of a Generalization Gap of Convolutional Neural Networks on COVID-19 X-Rays Classification
Publikováno v:
IEEE Access, Vol 9, Pp 72970-72979 (2021)
A number of recent papers have shown experimental evidence that suggests it is possible to build highly accurate deep neural network models to detect COVID-19 from chest X-ray images. In this paper, we show that good generalization to unseen sources
Externí odkaz:
https://doaj.org/article/a3ff791f2098417e9a50d9fda9ba332a
Autor:
Dianna L. Ng, Gregory M. Goldgof, Brian R. Shy, Andrew G. Levine, Joanna Balcerek, Sagar P. Bapat, John Prostko, Mary Rodgers, Kelly Coller, Sandra Pearce, Sergej Franz, Li Du, Mars Stone, Satish K. Pillai, Alicia Sotomayor-Gonzalez, Venice Servellita, Claudia Sanchez San Martin, Andrea Granados, Dustin R. Glasner, Lucy M. Han, Kent Truong, Naomi Akagi, David N. Nguyen, Neil M. Neumann, Daniel Qazi, Elaine Hsu, Wei Gu, Yale A. Santos, Brian Custer, Valerie Green, Phillip Williamson, Nancy K. Hills, Chuanyi M. Lu, Jeffrey D. Whitman, Susan L. Stramer, Candace Wang, Kevin Reyes, Jill M. C. Hakim, Kirk Sujishi, Fariba Alazzeh, Lori Pham, Edward Thornborrow, Ching-Ying Oon, Steve Miller, Theodore Kurtz, Graham Simmons, John Hackett, Michael P. Busch, Charles Y. Chiu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Highly accurate antibody tests for SARS-CoV-2 are needed for surveillance in low-prevalence populations. Here, the authors find seroprevalence of less than 1% in two San Francisco Bay Area populations at the beginning of April, and that seroreactivit
Externí odkaz:
https://doaj.org/article/b4b0b2c17edb43c98ec84b755fb3600a
Autor:
Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and expo
Externí odkaz:
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
Autor:
Sabine Ottilie, Gregory M. Goldgof, Andrea L. Cheung, Jennifer L. Walker, Edgar Vigil, Kenneth E. Allen, Yevgeniya Antonova-Koch, Carolyn W. Slayman, Yo Suzuki, Jacob D. Durrant
Publikováno v:
Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the essential proton pump Pma1p, a P-type ATPase, is a potentially effective therapeut
Externí odkaz:
https://doaj.org/article/fd41685e74f3424eaaeab6152fd0de81
Autor:
Gregory M. Goldgof, Jacob D. Durrant, Sabine Ottilie, Edgar Vigil, Kenneth E. Allen, Felicia Gunawan, Maxim Kostylev, Kiersten A. Henderson, Jennifer Yang, Jake Schenken, Gregory M. LaMonte, Micah J. Manary, Ayako Murao, Marie Nachon, Rebecca Murray, Maximo Prescott, Case W. McNamara, Carolyn W. Slayman, Rommie E. Amaro, Yo Suzuki, Elizabeth A. Winzeler
Publikováno v:
Scientific Reports, Vol 6, Iss 1, Pp 1-13 (2016)
Abstract The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4. We show here that S. cerevisiae also acquires mutations in a gene encoding
Externí odkaz:
https://doaj.org/article/18801bf6d83b4da390a0a3ecb536d0c8
Autor:
Michelle Wang, Gregory M. Goldgof, Ayan Patel, Barbee Whitaker, Artur Belov, Brian Chan, Evan Phelps, Benjamin Rubin, Steven Anderson, Atul J. Butte
Publikováno v:
Transfusion.
Autor:
Gregory M. Goldgof, Shenghuan Sun, Jacob Van Cleave, Linlin Wang, Fabienne Lucas, Laura Brown, Jacob D. Spector, Leonardo Boiocchi, Jeeyeon Baik, Menglei Zhu, Orly Ardon, Chuanyi M. Lu, Ahmet Dogan, Dmitry B. Goldgof, Iain Carmichael, Sonam Prakash, Atul J. Butte
Publikováno v:
bioRxiv
Morphology-based classification of cells in the bone marrow aspirate (BMA) is a key step in the diagnosis and management of hematologic malignancies. However, it is time-intensive and must be performed by expert hematopathologists and laboratory prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc01713385264e520fd8438b9942194
https://europepmc.org/articles/PMC9979993/
https://europepmc.org/articles/PMC9979993/
Autor:
Jennifer A. Yang, Bing Yu Zou, Frances Rocamora, Edgar Vigil, Prianka Kumar, Nina F. Gnädig, Alan F. Cowman, David A. Fidock, Roy Williams, Trevor Johnson, Madeline R. Luth, Danushka S. Marapana, Dylan Hutson, Marcus C. S. Lee, Tilla S. Worgall, Jianbo Huang, Gregory M. Goldgof, Gregory LaMonte, T. R. Santha Kumar, Jennifer K. Thompson, Timothy J. Egan, Roxanne Mohunlal, Sabine Ottilie, Dionicio Siegel, Elizabeth A. Winzeler, Andrea L. Cheung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent tran
Autor:
Patricia M. Kane, Jennifer H. Yang, Jacob D. Durrant, Emmanuelle V. LeBlanc, Roy Williams, Trey Ideker, Krypton Carolino, Luke Whitesell, Erich Hellemann, Leah E. Cowen, Jake Schenken, Gisel Lopez, Eddy Vigil, Karla P. Godinez-Macias, Madeline R. Luth, Dyann F. Wirth, Reysha Patel, Elizabeth A. Winzeler, Gregory M. Goldgof, Yo Suzuki, Miranda Song, Joshua R. Smith, Sabine Ottilie, Matthew Abraham, Melissa S. Love, Amanda K. Lukens, William H. Gerwick, Prianka Kumar, Case W. McNamara, Felicia Gunawan, Andrea L. Cheung, Maureen Tarsio
SummaryIn vitro evolution and whole genome analysis were used to comprehensively identify the genetic determinants of chemical resistance in the model microbe, Saccharomyces cerevisiae. Analysis of 355 curated, laboratory-evolved clones, resistant to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5f5d094b7b054084d42b418d86b527c
https://doi.org/10.1101/2021.02.17.430112
https://doi.org/10.1101/2021.02.17.430112