Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gregory M. Dillon"'
Autor:
Ashley N. Nelson, Michael S. Calhoun, Ankur M. Thomas, Jennifer L. Tavares, Daniel M. Ferretti, Gregory M. Dillon, Yael Mandelblat-Cerf
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Ischemic stroke is recognized as one of the leading causes of adult disability, morbidity, and death worldwide. Following stroke, acute neuronal excitotoxicity can lead to many deleterious consequences, one of which is the dysregulation of intracellu
Externí odkaz:
https://doaj.org/article/5592c98416e14b32b4800f26c4a8e30a
Autor:
Georgette L. Suidan, Daniel Duerschmied, Gregory M. Dillon, Veronique Vanderhorst, Thomas G. Hampton, Siu Ling Wong, Jaymie R. Voorhees, Denisa D. Wagner
Publikováno v:
PLoS ONE, Vol 8, Iss 8 (2013)
Externí odkaz:
https://doaj.org/article/86443a50c399466e8c37bf6b08db9e12
Autor:
Brenda Amaral, Andrew Capacci, Trip Anderson, Ceren Tezer, Bekim Bajrami, Mukesh Lulla, Brian Lucas, Jayanth V. Chodaparambil, Douglas Marcotte, P. Rajesh Kumar, Paramasivam Murugan, Kerri Spilker, Mike Cullivan, Ti Wang, Anton C. Peterson, Istvan Enyedy, Bin Ma, TeYu Chen, Zain Yousaf, Michael Calhoun, Olga Golonzhka, Gregory M. Dillon, Samir Koirala
Publikováno v:
ACS Chemical Neuroscience. 14:1080-1094
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e2475b48301c4e503991c19a53b9f3a
https://doi.org/10.1021/acschemneuro.2c00476
https://doi.org/10.1021/acschemneuro.2c00476
Autor:
Jayanth V. Chodaparambil, Benbo Gao, Gregory M Dillon, Hannah M. Kerns, Jaclyn L. Henderson, Douglas Marcotte, Ru Wei, Bekim Bajrami, Channa Bao
Publikováno v:
Cellular and Molecular Neurobiology. 41:669-685
Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785ba6754ca160aed7d4ffda2a0c284a
https://doi.org/10.1007/s10571-020-00875-6
https://doi.org/10.1007/s10571-020-00875-6
Autor:
Kristopher W King, Brenda Amaral, Eli Schuman, LaiYee Wong, Michael Rooney, Marta Nevalainen, Jun Feng, Paramasivam Murugan, Jayanth V. Chodaparambil, Thomas A. Patterson, Hannah Certo, Martin K Himmelbauer, Rab Gilfillan, Tamara Halkina, Sarah Lamore, J Howard Jones, Douglas Marcotte, Gregory M Dillon, Jaclyn L. Henderson, Thomas Hesson, P Rajesh Kumar, Edward Yin-Shiang Lin, Channa Bao, Felix Gonzalez-Lopez de Turiso, Joshua L Johnson, Michael Calhoun
Publikováno v:
Journal of medicinal chemistry. 64(9)
Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by 8 (cell IC50: 571 nM). Systematic optimization of this series of anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24de7147f81434a735de9781d30290ec
https://pubmed.ncbi.nlm.nih.gov/33944571
https://pubmed.ncbi.nlm.nih.gov/33944571
Autor:
Georgette L Suidan, Daniel Duerschmied, Gregory M Dillon, Veronique Vanderhorst, Thomas G Hampton, Siu Ling Wong, Jaymie R Voorhees, Denisa D Wagner
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59032 (2013)
The role of peripheral serotonin in nervous system development is poorly understood. Tryptophan hydroxylase-1 (TPH1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the pineal gland and is the rate-limit
Externí odkaz:
https://doaj.org/article/824dc76da543400cb374e94be31e4bee
Autor:
Channa, Bao, Bekim, Bajrami, Douglas J, Marcotte, Jayanth V, Chodaparambil, Hannah M, Kerns, Jaclyn, Henderson, Ru, Wei, Benbo, Gao, Gregory M, Dillon
Publikováno v:
Cellular and molecular neurobiology. 41(4)
Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6c6ff604205513513cb5b117098fe34
https://pubmed.ncbi.nlm.nih.gov/32424773
https://pubmed.ncbi.nlm.nih.gov/32424773
Autor:
Dania Rabah, Channa Bao, Gregory M Dillon, Jaclyn L. Henderson, Bekim Bajrami, Michael Calhoun, Kristopher W King, Brenda Amaral, John A. Joyce
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0228771 (2020)
PLoS ONE
PLoS ONE
Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to be an early initiating eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8432c06edf6c167c2d9a26d65d8068
https://doaj.org/article/4ad3843a90eb46f59942329ffdb2df81
https://doaj.org/article/4ad3843a90eb46f59942329ffdb2df81
Publikováno v:
Journal of Biological Chemistry. 289:15374-15383
Aberrant amyloid β (Aβ) production plays a causal role in Alzheimer disease pathogenesis. A major cellular pathway for Aβ generation is the activity-dependent endocytosis and proteolytic cleavage of the amyloid precursor protein (APP). However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9592200ff19ffcb3df12231094f57bb8
https://doi.org/10.1074/jbc.m113.541003
https://doi.org/10.1074/jbc.m113.541003
Autor:
Gregory M. Dillon, Delia S. Shelton, A. P. McKinney, Thomas J. Kornecook, Mitchell T. Ferguson, Jacob Marcus, Michael Caniga, Jean-Cosme Dodart
Publikováno v:
Behavioural Brain Research. 204:67-76
Sustained attention is defined as the ability or capacity to remain focused on the occurrence of rare events over long periods of time. We describe here the development of a novel, operant-based attention task that can be learned by mice in 8-10 days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1df64f5561279e71b9d6cd7b246735
https://doi.org/10.1016/j.bbr.2009.04.036
https://doi.org/10.1016/j.bbr.2009.04.036