Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Gregory M Laird"'
Autor:
Nathan W Cummins, Jason Baker, Rana Chakraborty, Patrick G Dean, Enrique Garcia-Rivera, Ashton Krogman, Shaji Kumar, Yury V Kuzmichev, Gregory M Laird, Alan Landay, Mathias Lichterfeld, Maryam Mahmood, Jeffrey Martinson, Mark Maynes, Sekar Natesampillai, Vincent Rajkumar, Yelizaveta Rassadkina, Kristen D. Ritter, Christina G Rivera, Stacey A Rizza, Krupa Subramanian, Aaron J Tande, Elizabeth R Wonderlich, Jennifer A Whitaker, John Zeuli, Andrew D Badley
Publikováno v:
EClinicalMedicine, Vol 42, Iss , Pp 101225- (2021)
Background: Achieving a functional or sterilizing cure for HIV will require identification of therapeutic interventions that reduce HIV reservoir size in infected individuals. Proteasome inhibitors, such as ixazomib, impact multiple aspects of HIV bi
Externí odkaz:
https://doaj.org/article/9bcbc1806c0c4535bde930e29c873a95
Autor:
Gregory M Laird, Evelyn E Eisele, S Alireza Rabi, Jun Lai, Stanley Chioma, Joel N Blankson, Janet D Siliciano, Robert F Siliciano
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003398 (2013)
HIV-1 persists in infected individuals in a stable pool of resting CD4(+) T cells as a latent but replication-competent provirus. This latent reservoir is the major barrier to the eradication of HIV-1. Clinical trials are currently underway investiga
Externí odkaz:
https://doaj.org/article/916e6c34afd9442080aebb7229dac655
Autor:
Natalie F. McMyn, Joseph Varriale, Emily J. Fray, Carolin Zitzmann, Hannah MacLeod, Jun Lai, Anushka Singhal, Milica Moskovljevic, Mauro A. Garcia, Brianna M. Lopez, Vivek Hariharan, Kyle Rhodehouse, Kenneth Lynn, Pablo Tebas, Karam Mounzer, Luis J. Montaner, Erika Benko, Colin Kovacs, Rebecca Hoh, Francesco R. Simonetti, Gregory M. Laird, Steven G. Deeks, Ruy M. Ribeiro, Alan S. Perelson, Robert F. Siliciano, Janet M. Siliciano
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART (t1/2 = 44 months). However, whether decay continues with long-term ART is unclear. Recent in
Externí odkaz:
https://doaj.org/article/16cb14484f3b4a688aeb5fd64cf309ef
Autor:
Sarah E. Benner, Yolanda Eby, Xianming Zhu, Reinaldo E. Fernandez, Eshan U. Patel, Jessica E. Ruff, Feben Habtehyimer, Haley A. Schmidt, Charles S. Kirby, Sarah Hussain, Darin Ostrander, Niraj M. Desai, Sander Florman, Meenakshi M. Rana, Rachel Friedman-Moraco, Marcus R. Pereira, Shikha Mehta, Peter Stock, Alexander Gilbert, Michele I. Morris, Valentina Stosor, Sapna A. Mehta, Catherine B. Small, Karthik Ranganna, Carlos A.Q. Santos, Saima Aslam, Jennifer Husson, Maricar Malinis, Nahel Elias, Emily A. Blumberg, Brianna L. Doby, Allan B. Massie, Melissa L. Smith, Jonah Odim, Thomas C. Quinn, Gregory M. Laird, Robert F. Siliciano, Dorry L. Segev, Andrew D. Redd, Christine M. Durand, Aaron A.R. Tobian
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
The HIV latent viral reservoir (LVR) remains a major challenge in the effort to find a cure for HIV. There is interest in lymphocyte-depleting agents, used in solid organ and bone marrow transplantation to reduce the LVR. This study evaluated the LVR
Externí odkaz:
https://doaj.org/article/09d1623efd834d26a727f8f8faacd04a
Autor:
Robert F. Siliciano, Dorry L. Segev, Gregory M. Laird, Alexandra M. Bender, Sander Florman, Kyungyoon J. Kwon, Craig Martens, Alyssa R. Martin, Briana A. Lynch, Thomas C. Quinn, Aaron A.R. Tobian, Christine M. Durand, Jada Hackman, Daniel Bruno, Janet D. Siliciano, Niraj M. Desai, Subul A. Beg, Andrew D. Redd
Publikováno v:
J Infect Dis
Background The human immunodeficiency virus (HIV)-1 latent reservoir (LR) in resting CD4+ T cells is a barrier to cure. LR measurements are commonly performed on blood samples and therefore may miss latently infected cells residing in tissues, includ
Autor:
Rebeka Bordi, Gregory M. Laird, Gregory D. Kirk, Shruti H. Mehta, Robert F. Siliciano, Kristen D. Ritter, Rafick Pierre Sekaly, Janet D. Siliciano, Jacqueline Astemborski
Publikováno v:
J Infect Dis
The latent reservoir for human immunodeficiency virus type 1 (HIV-1) in CD4+ T cells is a major barrier to cure. HIV-1–infected persons who inject drugs (PWID) often struggle to maintain suppression of viremia and experience nonstructured treatment
Autor:
Mary Carrington, Joseph Varriale, Robert F. Siliciano, Joshua M. Chevalier, Jane E. Blackmer, Ma Somsouk, Sarah E. Sweet, Kevin Einkauf, Erik Serrao, Stephane Hua, Bruce D. Walker, Janet M. Siliciano, Kaylee Chang, Mathias Lichterfeld, Michael J. Peluso, Ce Gao, Xiaoming Sun, Jeffrey M. Milush, Matthew Osborn, Tae Wook Chun, Rebecca Hoh, Xu G. Yu, Gregory M. Laird, Lynn N. Bertagnolli, Steven G. Deeks, Chenyang Jiang, Peter D. Burbelo, Ben Rhee, Alan Engelman, Samantha M.Y. Chen, Xiao-Dong Lian
Publikováno v:
Nature. 585:261-267
Sustained, drug-free control of HIV-1 replication is naturally achieved in less than 0.5% of infected individuals (here termed ‘elite controllers’), despite the presence of a replication-competent viral reservoir1. Inducing such an ability to spo
Autor:
Aaron J. Tande, Gregory M. Laird, Sekar Natesampillai, Maryam Mahmood, Mathias Lichterfeld, Rana Chakraborty, Kristen D. Ritter, K. G. Subramanian, Yury V Kuzmichev, Stacey A. Rizza, Alan L. Landay, Christina G. Rivera, Ashton Krogman, Shaji Kumar, Andrew D. Badley, Jeffrey Martinson, Nathan W. Cummins, Mark Maynes, Elizabeth R. Wonderlich, Jennifer A Whitaker, Yelizaveta Rassadkina, Enrique Garcia-Rivera, Jason V. Baker, Vincent Rajkumar, John D. Zeuli, Patrick G. Dean
Publikováno v:
EClinicalMedicine
EClinicalMedicine, Vol 42, Iss, Pp 101225-(2021)
EClinicalMedicine, Vol 42, Iss, Pp 101225-(2021)
Background Achieving a functional or sterilizing cure for HIV will require identification of therapeutic interventions that reduce HIV reservoir size in infected individuals. Proteasome inhibitors, such as ixazomib, impact multiple aspects of HIV bio
Autor:
Alexandra M. Bender, Janet D. Siliciano, Kyungyoon J. Kwon, Katherine M. Bruner, Hao Zhang, Christopher L. Nobles, Joshua T. Kufera, Gregory M. Laird, Steven G. Deeks, Ya Chi Ho, Annukka A.R. Antar, Lynn N. Bertagnolli, Frederic D. Bushman, Nikolas Wada, John R. Gregg, Srona Sengupta, Joseph B. Margolick, Subul A. Beg, Andrew E. Timmons, Adam A. Capoferri, Emily J. Fray, Katharine M. Jenike, Zheng Wang, Francesco R. Simonetti, Joel N. Blankson, Robert F. Siliciano
Publikováno v:
Nature
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays. The reservoir was defined with quant
Autor:
Ma Somsouk, Robert F. Siliciano, Gregory M. Laird, Steven A. Yukl, Sushama Telwatte, Peter W. Hunt, Shomyseh Sanjabi, Steven G. Deeks, Kristen D. Ritter, Jeffrey M. Milush, Norman G. Jones, Guorui Xie, Alexander R. Pico, Chuanyi M. Lu, Daniel Fulop, Nadia R. Roan, Shahzada Khan, Tsui-Hua Chen, Frank Wu, Martin Trapecar
Publikováno v:
Journal of Virology. 95
Latent HIV infection is the main barrier to cure, and most HIV-infected cells reside in the gut, where distinct but unknown mechanisms may promote viral latency. Transforming growth factor β (TGF-β), which induces the expression of CD103 on tissue-