Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Gregory M Kelly"'
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170812 (2017)
Mouse F9 cells differentiate to primitive endoderm (PrE) when treated with retinoic acid (RA). Differentiation is accompanied by increased reactive oxygen species (ROS) levels, and while treating F9 cells with antioxidants attenuates differentiation,
Externí odkaz:
https://doaj.org/article/eb9cf06a013544efabd0b01c1080c24d
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26484 (2011)
The Rho kinase pathway plays a key role in many early cell/tissue determination events that take place in embryogenesis. Rho and its downstream effector Rho kinase (ROCK) play pivotal roles in cell migration, apoptosis (membrane blebbing), cell proli
Externí odkaz:
https://doaj.org/article/1b4ffed8741a40518637d49cd1609df0
Publikováno v:
Journal of Developmental Biology, Vol 12, Iss 3, p 23 (2024)
Craniometaphyseal Dysplasia (CMD) is a rare skeletal disorder that can result from mutations in the ANKH gene. This gene encodes progressive anksylosis (ANK), which is responsible for transporting inorganic pyrophosphate (PPi) and ATP from the intrac
Externí odkaz:
https://doaj.org/article/69f3b1c0e0674e0789cfebe9ed789a6e
Autor:
Mohamed I. Gatie, Danielle M. Spice, Amritpal Garha, Adam McTague, Mariam Ahmer, Alexander V. Timoshenko, Gregory M. Kelly
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 623 (2022)
The regulation of proteins through the addition and removal of O-linked β-N-acetylglucosamine (O-GlcNAc) plays a role in many signaling events, specifically in stem cell pluripotency and the regulation of differentiation. However, these post-transla
Externí odkaz:
https://doaj.org/article/71ef96f853fa4042b9f491ba1483439d
Publikováno v:
Stem Cells and Development. 31:741-755
Hedgehog signaling is essential for vertebrate development, however, less is known about the negative regulators that influence this pathway during the differentiation of cell fates. Using the mouse P19 embryonal carcinoma cell model, Suppressor of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30aa64f07490587e3015df6ec26b33cb
https://doi.org/10.1089/scd.2022.0131
https://doi.org/10.1089/scd.2022.0131
Autor:
Francesco Casciello, Gregory M. Kelly, Priya Ramarao-Milne, Nabilah Kamal, Teneale A. Stewart, Pamela Mukhopadhyay, Stephen H. Kazakoff, Mariska Miranda, Dorim Kim, Felicity M. Davis, Nicholas K. Hayward, Paula M. Vertino, Nicola Waddell, Frank Gannon, Jason S. Lee
Publikováno v:
Cancer Research. 82:1208-1221
G9a and EZH2 are two histone methyltransferases commonly upregulated in several cancer types, yet the precise roles that these enzymes play cooperatively in cancer is unclear. We demonstrate here that frequent concurrent upregulation of both G9a and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3434303eda1b08a06c33e42ff992ec37
https://doi.org/10.1158/0008-5472.can-21-2218
https://doi.org/10.1158/0008-5472.can-21-2218
Publikováno v:
Stem Cells. 40:239-259
Metabolism plays a crucial role for cell survival and function; however, recent evidence has implicated it in regulating embryonic development. In the embryo, the inner cell mass undergoes orchestrated cellular divisions resulting in the formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f34684c9deedb7018c5fd7bd48295e7
https://doi.org/10.1093/stmcls/sxab022
https://doi.org/10.1093/stmcls/sxab022
Autor:
Jason S. Lee, Frank Gannon, Nicholas K. Hayward, Sudha Rao, Richard A. Scolyer, Georgina V. Long, James S. Wilmott, Ines P. Silva, Sayed Ali, Antonia L. Pritchard, Blake Ferguson, Nabilah Ahmad Kamal, Francesco Casciello, Robert McCuaig, Fares Al-Ejeh, Gregory M. Kelly
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a9c0a6b587f1884e5d344f74d08eca
https://doi.org/10.1158/1078-0432.22484013.v1
https://doi.org/10.1158/1078-0432.22484013.v1
Autor:
Jason S. Lee, Frank Gannon, Nicola Waddell, Paula M. Vertino, Nicholas K. Hayward, Felicity M. Davis, Dorim Kim, Mariska Miranda, Stephen H. Kazakoff, Pamela Mukhopadhyay, Teneale A. Stewart, Nabilah Kamal, Priya Ramarao-Milne, Gregory M. Kelly, Francesco Casciello
G9a and EZH2 are two histone methyltransferases commonly upregulated in several cancer types, yet the precise roles that these enzymes play cooperatively in cancer is unclear. We demonstrate here that frequent concurrent upregulation of both G9a and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ef525d0abe326283a0446da9b7dcb0
https://doi.org/10.1158/0008-5472.c.6513936.v1
https://doi.org/10.1158/0008-5472.c.6513936.v1
Autor:
Jason S. Lee, Frank Gannon, Nicholas K. Hayward, Sudha Rao, Richard A. Scolyer, Georgina V. Long, James S. Wilmott, Ines P. Silva, Sayed Ali, Antonia L. Pritchard, Blake Ferguson, Nabilah Ahmad Kamal, Francesco Casciello, Robert McCuaig, Fares Al-Ejeh, Gregory M. Kelly
Purpose:G9a histone methyltransferase exerts oncogenic effects in several tumor types and its inhibition promotes anticancer effects. However, the impact on checkpoint inhibitor blockade response and the utility of G9a or its target genes as a biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212c1c5ec946bb0211e34f7f3555120a
https://doi.org/10.1158/1078-0432.c.6531297.v1
https://doi.org/10.1158/1078-0432.c.6531297.v1