Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Gregory M Cote"'
Autor:
Gaylor Boulay, Liliane C. Broye, Rui Dong, Sowmya Iyer, Rajendran Sanalkumar, Yu-Hang Xing, Rémi Buisson, Shruthi Rengarajan, Beverly Naigles, Benoît Duc, Angela Volorio, Mary E. Awad, Raffaele Renella, Ivan Chebib, G. Petur Nielsen, Edwin Choy, Gregory M. Cote, Lee Zou, Igor Letovanec, Ivan Stamenkovic, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT
Externí odkaz:
https://doaj.org/article/fd00253648764577aeb52739a580a6a3
Autor:
Edwin Choy, Laura E MacConaill, Gregory M Cote, Long P Le, Jacson K Shen, Gunnlaugur P Nielsen, Anthony J Iafrate, Levi A Garraway, Francis J Hornicek, Zhenfeng Duan
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101283 (2014)
The molecular mechanisms underlying chordoma pathogenesis are unknown. We therefore sought to identify novel mutations to better understand chordoma biology and to potentially identify therapeutic targets. Given the relatively high costs of whole gen
Externí odkaz:
https://doaj.org/article/a416189e9d1e48aeb8828b740d9038ee
Autor:
Jonathan A. Saenger, MD, Ismail Tahir, MBBChBAO, Manuela Födinger, MD, Gregory M. Cote, MDPhD, Ashok Muniappan, MD, Florian J. Fintelmann, MD
Publikováno v:
Radiology Case Reports, Vol 18, Iss 10, Pp 3586-3591 (2023)
Patients with Li-Fraumeni syndrome (LFS) are prone to develop a variety of malignancies due to insufficient activity of the encoded tumor suppressor protein P53, including adrenocortical carcinoma, breast cancer, lung cancer, pancreatic cancer, and s
Externí odkaz:
https://doaj.org/article/3e4c389e21714c91a432c1b718520cba
Autor:
Mrinal Gounder, Ravin Ratan, Thierry Alcindor, Patrick Schöffski, Winette T. van der Graaf, Breelyn A. Wilky, Richard F. Riedel, Allison Lim, L. Mary Smith, Stephanie Moody, Steven Attia, Sant Chawla, Gina D’Amato, Noah Federman, Priscilla Merriam, Brian A. Van Tine, Bruno Vincenzi, Charlotte Benson, Nam Quoc Bui, Rashmi Chugh, Gabriel Tinoco, John Charlson, Palma Dileo, Lee Hartner, Lore Lapeire, Filomena Mazzeo, Emanuela Palmerini, Peter Reichardt, Silvia Stacchiotti, Howard H. Bailey, Melissa A. Burgess, Gregory M. Cote, Lara E. Davis, Hari Deshpande, Hans Gelderblom, Giovanni Grignani, Elizabeth Loggers, Tony Philip, Joseph G. Pressey, Shivaani Kummar, Bernd Kasper
Publikováno v:
New England Journal of Medicine. 388:898-912
Autor:
Santiago A. Lozano‐Calderón, Jose Ignacio Albergo, Olivier Q. Groot, Nelson A. Merchan, Jad M. El Abiad, Vanessa Salinas, Luis Carlos Gomez Mier, Camilo Soto Montoya, Marco L. Ferrone, John E. Ready, Francisco J. Linares, Adam S. Levin, Manuel Peleteiro Pensado, José Juan Pozo Kreilinger, Irene Barrientos Ruiz, Eduardo J. Ortiz‐Cruz, Mark C. Gebhardt, Gregory M. Cote, Edwin Choy, Dimitrios Spentzos, Yin P. Hung, Vikram Deshpande, Ivan A. Chebib, Robert Allan McCulloch, Germán Farfalli, Luis Aponte Tinao, Carol D. Morris, Gunnlaugur Petur Nielsen, Megan E. Anderson, Lee M. Jeys
Publikováno v:
Cancer. 129:60-70
Survival in patients who have Ewing sarcoma is correlated with postchemotherapy response (tumor necrosis). This treatment response has been categorized as the response rate, similar to what has been used in osteosarcoma. There is controversy regardin
Autor:
Xiaoyang Li, Dylan C. Dean, Gregory M. Cote, Lee Zou, Francis J. Hornicek, Shengji Yu, Zhenfeng Duan
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Background: Ataxia-telangiectasia and Rad3 related protein kinase (ATR) is an essential regulator of the DNA damage response in various cancers; however, its expression and roles in osteosarcoma are unclear. We therefore chose to evaluate the signifi
Externí odkaz:
https://doaj.org/article/2d822bbd82db4cf9909685368289b740
Autor:
Zhenfeng Duan, Francis J. Hornicek, Henry Mankin, Yangyang Wang, Xinhui Wang, Soldano Ferrone, Ivan Chebib, G. Petur Nielsen, Joseph Schwab, David Harmon, Pei Yang, Edwin Choy, Gregory M. Cote, Jacson K. Shen
PDF file - 40K, Supplementary Figure S1. Antibodies that failed to show sufficient specificity for PD-L1 by flow cytometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a2e7d3a38e23f61bc5b4376e4a40c0
https://doi.org/10.1158/2326-6066.22538627.v1
https://doi.org/10.1158/2326-6066.22538627.v1
Autor:
Zhenfeng Duan, Francis J. Hornicek, Henry Mankin, Yangyang Wang, Xinhui Wang, Soldano Ferrone, Ivan Chebib, G. Petur Nielsen, Joseph Schwab, David Harmon, Pei Yang, Edwin Choy, Gregory M. Cote, Jacson K. Shen
PDF file - 53K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199bfe14627add08edf4f9cdab5e4230
https://doi.org/10.1158/2326-6066.22538624
https://doi.org/10.1158/2326-6066.22538624
Autor:
Walter, Banfield, Myrsini, Ioakeim-Ioannidou, Saveli, Goldberg, Soha, Ahmed, Joseph H, Schwab, Gregory M, Cote, Edwin, Choy, John H, Shin, Francis J, Hornicek, Norbert J, Liebsch, Yen-Lin E, Chen, Shannon M, MacDonald, Thomas F, DeLaney
Publikováno v:
Radiotherapy and Oncology. 171:139-145
Treatment of spine and sacral chordoma generally involves surgical resection, usually in conjunction with radiation therapy.In certain locations, resection may result in significant neurological dysfunction, so definitive radiation has been used as a
Autor:
Edwin Choy, Gregory M Cote, M Dror Michaelson, Lori Wirth, Justin F Gainor, Alona Muzikansky, Lecia V Sequist, Ryan J Sullivan, Panagiotis M Fidias, Alice Shaw, Rebecca S Heist
Publikováno v:
The Oncologist. 27:600-606
Bone metastases are often difficult to manage as they can be symptomatic and skeletal-related events (SREs) can contribute to significant morbidity and declines in performance status. We sought to identify a novel medical treatment for bone metastasi