Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Gregory M Alushin"'
Autor:
Lin Mei, Santiago Espinosa de los Reyes, Matthew J Reynolds, Rachel Leicher, Shixin Liu, Gregory M Alushin
Publikováno v:
eLife, Vol 9 (2020)
The actin cytoskeleton mediates mechanical coupling between cells and their tissue microenvironments. The architecture and composition of actin networks are modulated by force; however, it is unclear how interactions between actin filaments (F-actin)
Externí odkaz:
https://doaj.org/article/b10232867b744f808e382a22565469d5
Publikováno v:
eLife, Vol 6 (2017)
Despite extensive scrutiny of the myosin superfamily, the lack of high-resolution structures of actin-bound states has prevented a complete description of its mechanochemical cycle and limited insight into how sequence and structural diversification
Externí odkaz:
https://doaj.org/article/28df26c4926a470896c6253ed6523571
Autor:
Xiaoyu Sun, Gregory M. Alushin
Publikováno v:
FEBS J
The actin cytoskeleton orchestrates cell mechanics and facilitates the physical integration of cells into tissues, while tissue-scale forces and extracellular rigidity in turn govern cell behavior. Here we discuss recent evidence that actin filaments
Publikováno v:
Proceedings of the National Academy of Sciences. 119
To orchestrate cell mechanics, trafficking, and motility, cytoskeletal filaments must assemble into higher-order networks whose local subcellular architecture and composition specify their functions. Cross-linking proteins bridge filaments at the nan
Autor:
Rui Gong, Fangfang Jiang, Zane G. Moreland, Matthew J. Reynolds, Santiago Espinosa de los Reyes, Pinar Gurel, Arik Shams, James B. Heidings, Michael R. Bowl, Jonathan E. Bird, Gregory M. Alushin
Publikováno v:
Science Advances. 8
The motor protein myosin-15 is necessary for the development and maintenance of mechanosensory stereocilia, and mutations in myosin-15 cause hereditary deafness. In addition to transporting actin regulatory machinery to stereocilia tips, myosin-15 di
Publikováno v:
Nature. 611(7935)
ATP-hydrolysis-coupled actin polymerization is a fundamental mechanism of cellular force generation
SummaryATP hydrolysis-coupled actin polymerization is a fundamental mechanism of cellular force generation. Force and actin filament (F-actin) nucleotide state in turn modulate the engagement of actin binding proteins (ABPs) to regulate actin dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc9676b36c9f89adbafd80df1034a7c6
https://doi.org/10.1101/2022.06.02.494606
https://doi.org/10.1101/2022.06.02.494606
Autor:
Rajarshi P. Ghosh, Lin Ning, Jan Liphardt, Po-Ssu Huang, Muneaki Nakamura, Namrata Anand, Michael Z. Lin, Rui Gong, Sasha Zemsky, Gregory M. Alushin, Robert Chen, Paul V. Ruijgrok, Alexander E. Chu, Zev Bryant, Vipul T. Vachharajani, Raphael R. Eguchi
Publikováno v:
Nature Chemical Biology. 17:540-548
Precision tools for spatiotemporal control of cytoskeletal motor function are needed to dissect fundamental biological processes ranging from intracellular transport to cell migration and division. Direct optical control of motor speed and direction
To fulfill the cytoskeleton’s diverse functions in cell mechanics and motility, actin networks with specialized architectures are built by crosslinking proteins, which bridge filaments to control micron-scale network geometry through nanoscale bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f59dc6c8d5e02b317f1b3f37ce41ff4
https://doi.org/10.1101/2021.12.07.471696
https://doi.org/10.1101/2021.12.07.471696
Autor:
Yasuharu Takagi, Michael R. Bowl, James R. Sellers, Jesse C. Werth, Elizabeth A. Wilson, Arik Shams, Zane G. Moreland, Andrew Parker, Randall Harley, Stacey M. Cole, Steve D.M. Brown, Gregory M. Alushin, Fangfang Jiang, Susan Morse, Jonathan E. Bird, Melanie Barzik, Carlos A. Aguilar, Rui Gong, Daniel C. Sutton, Christian C. Faaborg-Andersen, Thomas B. Friedman
SUMMARYThe assembly and maintenance of actin-based mechanosensitive stereocilia in the cochlea is critical for lifelong hearing. Myosin-15 (MYO15) is hypothesized to modulate stereocilia height by trafficking actin regulatory proteins to their tip co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633ca048bbe52ea2dce53eef8777a33e
https://doi.org/10.1101/2021.07.09.451618
https://doi.org/10.1101/2021.07.09.451618