Výsledky vyhledávání - "Gregory M, Shutske"

Synthesis of the novel thieno[4,3,2-ef][1,4]benzoxazepine ring system: 4,5-Dihydro-3-(4-pyridinyl)thieno[4,3,2-ef][1,4]benzox-azepine maleate

Autor: Dirk Friedrich, John Dick Tomer, Gregory M. Shutske

Publikováno v: Journal of Heterocyclic Chemistry. 34:1769-1772

4,5-Dihydro-3-(4-pyridinyl)-thieno[4,3,2-ef][1,4]benzoxazepine maleate 2 has been synthesized from 3-amino-4-fluorobenzo[fc]thiophene by employing an intramolecular nucleophilic aromatic fluoride displacement. In the presence of strong base and heat,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fee535f8e89be777d952a0f6b2b6868
https://doi.org/10.1002/jhet.5570340621

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Synthesis of 1-alkyl-2,3-dihydro-2-(4-pyridinyl)-1H-isoindoles as potential selective serotonin reuptake inhibitors

Autor: Gregory M. Shutske, Kevin J. Kapples

Publikováno v: Journal of Heterocyclic Chemistry. 34:1335-1338

Two 2,3-dihydro-2-(4-pyridinyl)-1H-isoindoles 2a,b have been synthesized by the reaction of isoindoline with 4-chloropyridines. In addition, a number of 1-alkyl-2,3-dihydro-2-(4-pyridinyl)-1H-isoindoles 2c-h were obtained from 2-(4-pyridinyl)phthalim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbf720d16e0586bf675a2f3cbb60d97c
https://doi.org/10.1002/jhet.5570340440

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Synthesis of some piperazinylpyrazolo[3,4-b]pyridines as selective serotonin re-uptake inhibitors

Autor: Gregory M. Shutske, Joachim E. Roehr

Publikováno v: Journal of Heterocyclic Chemistry. 34:789-795

A number of 3-substituted 6-piperazinylpyrazolo[3,4-b]pyridines were synthesized from 2,6-difluoropyridine by directed ortho metallation and sequential intra- and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bae61c0d81f1924a91d8b0f2e31f05c3
https://doi.org/10.1002/jhet.5570340314

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Patent Update: Central & Peripheral Nervous System: Recent patent activity relating to serotonin pharmacology

Autor: Gregory M Shutske

Publikováno v: Expert Opinion on Therapeutic Patents. 4:1233-1241

Recent patents are reviewed for compounds that seek to treat various medical disorders by altering the neurotransmitter serotonin (5-HT). Besides selective 5-HT reuptake blockers, 5-HT1-like agonists for use in migraine are covered, as well as potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25e2ad14610504f582a1d8fe07b2eed4
https://doi.org/10.1517/13543776.4.10.1233

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Overview Central & Peripheral Nervous System: Recent developments in serotonin reuptake inhibitors

Autor: Gregory M Shutske

Publikováno v: Expert Opinion on Therapeutic Patents. 4:335-341

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1cd7b8d3cb4c4db971efc4d03470a4f
https://doi.org/10.1517/13543776.4.4.335

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Synthesis and in vitro acetylcholinesterase inhibitory activity of some 1-substituted analogues of velnacrine

Autor: Gregory M. Shutske, Kevin J. Kapples, Francis P. Huger, Gina M. Bores

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2789-2792

A number of analogues of 9-amino-1,2,3,4-tetrahydro-1-acridinol (velnacrine), with 1-position substituents other than hydroxy, were prepared and evaluated for in vitro acetylcholinesterase inhibition.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1a8c0fe718cc58393b85bacf6d15f11
https://doi.org/10.1016/s0960-894x(01)80765-4

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Synthesis of Some amino-4,5-dihydropyrazolo[3,4-a]acridines as potential cholinesterase inhibitors

Autor: Gregory M. Shutske, John Dick Tomer

Publikováno v: Journal of Heterocyclic Chemistry. 30:23-27

A synthesis of the 4,5-dihydro derivatives of the previously known pyrazolo[3,4-a]acridine ring system is described. The reaction of a 3,4-dihydroacridin-1(2H)-one with N,N-dimethylformamide dimethyl acetal gave a reactive enamino ketone, which yield

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a491c570535627462612c18434bbcf63
https://doi.org/10.1002/jhet.5570300104

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ChemInform Abstract: A Novel Synthesis of the Isoxazolo(5,4,3-kl)acridine Ring System

Autor: Gregory M. Shutske

Publikováno v: ChemInform. 22

The Schmidt reaction of 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-one (1) is described. In addition to the expected isomeric lactams, 3-phenyl-5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-4-one (3) and 7,8-dihydro-3-phenyl-4H-isoxazolo[4,5-b]azepin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d13e6bf48891b3307371fb20a3f596bf
https://doi.org/10.1002/chin.199111200

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