Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gregory Locke"'
Autor:
Chan Gao, Michael Quigley, Dandan Zhao, Jennifer Koenitzer, Dan You, Stephen Hillerman, Gregory Locke, Charu Chaudhry, Caitlyn Stromko, Anwar Murtaza, Yi Fan, Yali Chen, Stephanie Briceno, Elizabeth Duperret, Johnni Gullo-Brown, John Feder, Joshua Curtin, Andrew P Degnan, Godwin Kumi, Mark Wittman, Benjamin M Johnson, Karen E Parrish, Giridharan Gokulrangan, John T Hunt, Luisa Salter-Cid, Emma Lees, Jinqi Liu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) has been demonstrated as a negative intracellular immune checkpoint in mediating antitumor immunity in studies with HPK1 knockout and kinase dead mice. Pharmacological inhibition of HPK1 i
Externí odkaz:
https://doaj.org/article/ca18b70501584617bef15c4ef9806fc2
Autor:
Lisa M. Kopcho, Gregory Locke, Jovita Marcinkeviciene, Ying Luo, Wenjun Jiang, Robert A. Copeland
Publikováno v:
Archives of Biochemistry and Biophysics. 390:101-108
Steady-state kinetics, equilibrium binding, and primary substrate kinetic isotope effect studies revealed that the reduction of crotonyl-CoA by NADH, catalyzed by Haemophilus influenzae enoyl-ACP reductase (FabI), follows a rapid equilibrium random k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5246db1f617234c7fda8fc90242c52
https://doi.org/10.1006/abbi.2001.2349
https://doi.org/10.1006/abbi.2001.2349
Autor:
Lisa M. Kopcho, Jovita Marcinkeviciene, M. John Rogers, Wenjun Jiang, Gregory Locke, Robert A. Copeland
Publikováno v:
Archives of Biochemistry and Biophysics. 377:178-186
We report the identification, expression, and characterization of a second Dihydroorotate dehydrogenase (DHODase A) from the human pathogen Enterococcus faecalis. The enzyme consists of a polypeptide chain of 322 amino acids that shares 68% identity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e02deddf5d56b466caa78e1841216bb
https://doi.org/10.1006/abbi.2000.1769
https://doi.org/10.1006/abbi.2000.1769
Publikováno v:
Biochemistry. 39(27)
Chemical modification, mutagenesis, chemical rescue, and isotope effect studies are used to identify and probe the roles of several conserved amino acid groups in catalysis by human dihydroorotate dehydrogenase. Time- and pH-dependent inactivation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d7634e26b49f8e0856c1c45acc9d98
https://pubmed.ncbi.nlm.nih.gov/10891080
https://pubmed.ncbi.nlm.nih.gov/10891080