Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gregory L. Lyford"'
Autor:
Suvro Chatterjee, Steven M. Miller, Vijay H. Shah, Michael G. Sarr, Gianrico Farrugia, Gregory L Lyford, Joseph H. Szurszewski, Peter R. Strege, Simon J. Gibbons, Inja Lim
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 288:G7-G14
Carbon monoxide (CO) is increasingly recognized as a physiological messenger. CO is produced in the gastrointestinal tract with diverse functions, including regulation of gastrointestinal motility, interacting with nitric oxide (NO) to mediate neurot
Autor:
Gianrico Farrugia, Gregory L Lyford
Publikováno v:
Current Opinion in Pharmacology. 3:583-587
A requirement for normal gastrointestinal motility is the tight regulation of ion channels expressed in interstitial cells of Cajal and smooth muscle. Interstitial cells of Cajal generate the slow wave and amplify neuronal signals; smooth muscle func
Autor:
Lawrence J. Burgart, C. L. He, Scott A. Strong, Tonia M. Young-Fadok, Gregory L Lyford, Joseph H. Szurszewski, Tracy L. Hull, Edy E. Soffer, Gianrico Farrugia, Anthony J. Senagore
Publikováno v:
Gut. 51:496-501
Background: Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation. Aims: The aims of this study were t
Autor:
Gregory L. Lyford, Frank P. Houston, Carol A. Barnes, Paul F. Worley, Gail D. Stevenson, John F. Guzowski, James L. McGaugh
Publikováno v:
The Journal of Neuroscience. 20:3993-4001
It is widely believed that the brain processes information and stores memories by modifying and stabilizing synaptic connections between neurons. In experimental models of synaptic plasticity, such as long-term potentiation (LTP), the stabilization o
Publikováno v:
The Journal of Neuroscience. 17:2876-2885
Normal human aging is associated with selective changes in cognition that are attributable, in part, to dysfunction of hippocampal pathways. Rodents also exhibit age-dependent hippocampal dysfunction that results in spatial memory deficits and a corr
Autor:
Laura K. Sanders, Walter E. Kaufmann, Nancy A. Jenkins, Paul F. Worley, Kanato Yamagata, Gregory L. Lyford, Carol A. Barnes, Neal G. Copeland, Debra J. Gilbert, Anthony Lanahan
Publikováno v:
Neuron. 14(2):433-445
Neuronal activity is an essential stimulus for induction of plasticity and normal development of the CNS. We have used differential cloning techniques to identify a novel immediate-early gene (IEG) cDNA that is rapidly induced in neurons by activity
Autor:
Gregory L. Lyford, Leonard E. Jarrard
Publikováno v:
Psychobiology. 19:157-160
Using a within-subjects design, rats were trained to run on a radial maze with a procedure that involved two types of learning (pi ace and eue) and two memory functions (working and reference memory). After performance had stabilized, injections of s
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 16(2)
Otilonium bromide (OB) is used as an intestinal antispasmodic. The mechanism of action of OB is not completely understood. As Ca(2+) entry into intestinal smooth muscle is required to trigger contractile activity, our hypothesis was that OB blocked C
Autor:
Gregory L Lyford, Joseph H. Szurszewski, Gianrico Farrugia, Simon J. Gibbons, Steven M. Miller, Yijun Ou, Leonid G. Ermilov, James L. Rae, Allan R. Shepard, Peter R. Strege
Publikováno v:
American journal of physiology. Cell physiology. 283(3)
Smooth muscle exhibits mechanosensitivity independent of neural input, suggesting that mechanosensitive pathways reside within smooth muscle cells. The native L-type calcium current recorded from human intestinal smooth muscle is modulated by stretch
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The activity-regulated, cytoskeletal-associated gene, arc, is a brain- enriched immediate-early gene whose expression is rapidly induced in the striatum by dopamine receptor agonists. This rapid induction of arc in the striatum is similar to that of