Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Gregory L. Beatty"'
Autor:
Stacy K. Thomas, Max M. Wattenberg, Shaanti Choi-Bose, Mark Uhlik, Ben Harrison, Heather Coho, Christopher R. Cassella, Meredith L. Stone, Dhruv Patel, Kelly Markowitz, Devora Delman, Michael Chisamore, Jeremy Drees, Nandita Bose, Gregory L. Beatty
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could
Externí odkaz:
https://doaj.org/article/83508be0427a42c987caca447a63c531
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Cancer incidence and mortality are growing worldwide. With a lack of optimal treatments across many cancer types, there is an unmet need for the development of novel treatment strategies for cancer. One approach is to leverage the immune system for i
Externí odkaz:
https://doaj.org/article/54164dd7590849d491f653b94e4d1701
Autor:
Meredith L. Stone, Jesse Lee, Veronica M. Herrera, Kathleen Graham, Jae W. Lee, Austin Huffman, Heather Coho, Evan Tooker, Max I. Myers, Michael Giannone, Yan Li, Thomas H. Buckingham, Kristen B. Long, Gregory L. Beatty
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Agonist CD40 antibodies are under clinical development in combination with chemotherapy as an approach to prime for antitumor T cell immunity. However, treatment with anti-CD40 is commonly accompanied by both systemic cytokine release and liver trans
Externí odkaz:
https://doaj.org/article/a6e788afd3834015b4e4f598ab882751
Autor:
Max M. Wattenberg, Veronica M. Herrera, Michael A. Giannone, Whitney L. Gladney, Erica L. Carpenter, Gregory L. Beatty
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Agonistic anti-CD40 monoclonal antibody (mAb) therapy in combination with chemotherapy (chemoimmunotherapy) shows promise for the treatment of pancreatic ductal adenocarcinoma (PDA). To gain insight into immunological mechanisms of response and resis
Externí odkaz:
https://doaj.org/article/530321151d0149bdb9993c0278786f9e
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Pancreatic ductal adenocarcinoma (PDAC) shows remarkable propensity to metastasize. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multi-step process concluding wit
Externí odkaz:
https://doaj.org/article/1a32e15c2a664f4f8d4d9e2144eb9916
Autor:
Jesse Lee, Gregory L. Beatty
Publikováno v:
Cancers, Vol 13, Iss 13, p 3179 (2021)
Cancer triggers the systemic release of inflammatory molecules that support cancer cell metastasis and immune evasion. Notably, this biology shows striking similarity to an acute phase response that is coordinated by the liver. Consistent with this,
Externí odkaz:
https://doaj.org/article/3895b1428afc49ca8f34f3f559b48253
Autor:
Jae W. Lee, Gregory L. Beatty
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 5 (2019)
The liver is the most common organ site of cancer metastasis. Molecular determinants of this organotropism, though, are poorly understood. We recently showed that hepatocytes regulate the formation of a “pro-metastatic” niche in the liver via the
Externí odkaz:
https://doaj.org/article/8fd664d118684eaeb41a032f2962ea6e
Autor:
Gregory L. Beatty, Donald M. O'Rourke, E. John Wherry, Jiasi Vicky Zhang, Logan Y. Zhang, Oliver Y. Tang, Joey H. Li, Devora Delman, MacLean P. Nasrallah, Renee B. Chang, Zev A. Binder, Cécile Alanio
Supplementary Figure from Immunologic Features in De Novo and Recurrent Glioblastoma Are Associated with Survival Outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c01a446169490839c0c6dc2a21f1e5d
https://doi.org/10.1158/2326-6066.22544480
https://doi.org/10.1158/2326-6066.22544480
Autor:
Gregory L. Beatty, Donald M. O'Rourke, E. John Wherry, Jiasi Vicky Zhang, Logan Y. Zhang, Oliver Y. Tang, Joey H. Li, Devora Delman, MacLean P. Nasrallah, Renee B. Chang, Zev A. Binder, Cécile Alanio
Glioblastoma (GBM) is an immunologically “cold” tumor characterized by poor responsiveness to immunotherapy. Standard of care for GBM is surgical resection followed by chemoradiotherapy and maintenance chemotherapy. However, tumor recurrence is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd5ef061cd2c2e89923e8cc22a8cddf
https://doi.org/10.1158/2326-6066.c.6550655
https://doi.org/10.1158/2326-6066.c.6550655
Autor:
Carl H. June, Michael Kalos, Steven M. Albelda, Bruce L. Levine, Yangbing Zhao, Anne Chew, Gabriela Plesa, Michael C. Soulen, Drew A. Torigian, Marcela V. Maus, Andrew R. Haas, Gregory L. Beatty
Fig. S1. CARTmeso cell manufacturing and treatment schedules. Fig. S2. Detection of human anti-chimeric antibody responses in patients post-CARTmeso cell infusion. Fig. S3. Serum cytokines and chemokines in PDA patient 21211-101. Fig. S4. CARTmeso cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0d6d8923a7103805d921bd44444646
https://doi.org/10.1158/2326-6066.22535990
https://doi.org/10.1158/2326-6066.22535990