Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Gregory L, Challis"'
Autor:
Yoana D. Petrova, Jinlian Zhao, Gordon Webster, Alex J. Mullins, Katherine Williams, Amal S. Alswat, Gregory L. Challis, Andy M. Bailey, Eshwar Mahenthiralingam
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 10, Pp 2547-2561 (2022)
Abstract Burkholderia have potential as biocontrol agents because they encode diverse biosynthetic gene clusters (BGCs) for a range of antimicrobial metabolites. Given the opportunistic pathogenicity associated with Burkholderia species, heterologous
Externí odkaz:
https://doaj.org/article/65ebf345b1164a598faba768867e02b0
Autor:
Thierry Izoré, Y. T. Candace Ho, Joe A. Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L. Steer, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L. Challis, Elizabeth H. Krenske, Nadine Ziemert, Colin J. Jackson, Max J. Cryle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes assembling complex natural products. Here, the structures of a Thermobifida fusca NRPS condensation domain bound to the substrate-bearing peptidyl carrier protein (PCP) domain provid
Externí odkaz:
https://doaj.org/article/fbb66a8fa3204b6a841066cc1c1e62db
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-12 (2020)
Abstract Background Mithramycin is an anti-tumor compound of the aureolic acid family produced by Streptomyces argillaceus. Its biosynthesis gene cluster has been cloned and characterized, and several new analogs with improved pharmacological propert
Externí odkaz:
https://doaj.org/article/50b1fd8fbd2a4622a5923c0d6b17dc07
Autor:
Alex J. Mullins, Gordon Webster, Hak Joong Kim, Jinlian Zhao, Yoana D. Petrova, Christina E. Ramming, Matthew Jenner, James A. H. Murray, Thomas R. Connor, Christian Hertweck, Gregory L. Challis, Eshwar Mahenthiralingam
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Natural products that possess alkyne or polyyne moieties have been isolated from a variety of biological sources and possess a broad a range of bioactivities. In bacteria, the basic biosynthesis of polyynes is known, but their biosynthetic g
Externí odkaz:
https://doaj.org/article/b1b4253ed1464c9da85b6b1a1b4667c8
Autor:
Chuan Huang, Daniel Zabala, Emmanuel L C de los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Publikováno v:
Nucleic Acids Research. 51:1488-1499
Advances in DNA sequencing technology and bioinformatics have revealed the enormous potential of microbes to produce structurally complex specialized metabolites with diverse uses in medicine and agriculture. However, these molecules typically requir
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0229925 (2020)
Basidiomycete fungi are a rich source of natural products with a diverse array of potentially exploitable bioactivities. Two dimeric sesquiterpenes, bovistol B (1) and D (2), and one monomeric sesquiterpene, strossmayerin (7), were isolated from the
Externí odkaz:
https://doaj.org/article/c3b5de183f3249d8af435fee64c63e51
Autor:
Lauren Ray, Timothy R. Valentic, Takeshi Miyazawa, David M. Withall, Lijiang Song, Jacob C. Milligan, Hiroyuki Osada, Shunji Takahashi, Shiou-Chuan Tsai, Gregory L. Challis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Polyketides are typically assembled from a starter unit and malonyl- and/or methylmalonyl-CoA-derived extender units, but the macrolide antibiotics stambomycins incorporate non-standard alkylmalonyl-CoA extender units. Here, the authors describe the
Externí odkaz:
https://doaj.org/article/f13d3b5a30894fbfb9a232d6e4194380
Autor:
Sheida Heidarian, Fatemeh Mohammadipanah, Abdolvahab Maghsoudlou, Yousef Dashti, Gregory L. Challis
Publikováno v:
Frontiers in Microbiology, Vol 9 (2019)
Discovery of environmentally safe anti-fouling agent is currently of considerable interest, due to the continuous impact of biofoulers on the marine habitats and the adverse effects of biocides on the environment. This study reports the anti-adhesion
Externí odkaz:
https://doaj.org/article/52e2cac234c1491bbd7b22d7c817fbb8
Autor:
Max J. Cryle, Thierry Izoré, Julien Tailhades, Ka Ho Chow, Colin J. Jackson, Gregory L. Challis, David Steer, Elizabeth H. Krenske, Robert J. A. Goode, Nadine Ziemert, Manuela Tosin, Ralf B. Schittenhelm, Y. T. Candace Ho, Athina Gavriilidou, Joe A. Kaczmarski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a pepti
Autor:
Ioanna T. Nakou, Eshwar Mahenthiralingam, Matthew Jenner, Joleen Masschelein, Gregory L. Challis, Isolda Romero-Canelón, Yousef Dashti
Publikováno v:
Angewandte Chemie (International Ed. in English)
A gene cluster encoding a cryptic trans‐acyl transferase polyketide synthase (PKS) was identified in the genomes of Burkholderia gladioli BCC0238 and BCC1622, both isolated from the lungs of cystic fibrosis patients. Bioinfomatics analyses indicate