Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gregory Kirkpatrick"'
Autor:
Giovanny Hernandez, Taylor S. Mills, Jennifer L. Rabe, James S. Chavez, Susan Kuldanek, Gregory Kirkpatrick, Leila Noetzli, Widian K. Jubair, Michelle Zanche, Jason R. Myers, Brett M. Stevens, Courtney J. Fleenor, Biniam Adane, Charles A. Dinarello, John Ashton, Craig T. Jordan, Jorge Di Paola, James R. Hagman, V. Michael Holers, Kristine A. Kuhn, Eric M. Pietras
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation and progressive destruction of joint tissue. It is also characterized by aberrant blood phenotypes including anemia and suppressed lymphopoiesis that
Externí odkaz:
https://doaj.org/article/eca59744a0444860b5057f8bf06972fb
Autor:
Courtney L. Jones, Craig T. Jordan, Michael U. Callaghan, Jesse W. Rowley, Jorge Di Paola, Gregory Kirkpatrick, Joy M. Fulbright, Madhvi Rajpurkar, Brett M. Stevens, Eric M. Pietras, Marlie H. Fisher, Kenneth Jones, Christopher C. Porter, Arthur Gutierrez-Hartmann, Megan A. Cooper
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 18 (2020)
JCI Insight, Vol 5, Iss 18 (2020)
ETV6 is an ETS family transcription factor that plays a key role in hematopoiesis and megakaryocyte development. Our group and others have identified germline mutations in ETV6 resulting in autosomal dominant thrombocytopenia and predisposition to ma
Autor:
Jorge Di Paola, Michelle Zanche, Jason R. Myers, Brett M. Stevens, James S. Chavez, Susan Kuldanek, John M. Ashton, Eric M. Pietras, Giovanny Hernandez, James Hagman, Jennifer L. Rabe, Taylor S. Mills, Craig T. Jordan, V. Michael Holers, Courtney J. Fleenor, Leila Noetzli, Gregory Kirkpatrick, Kristine A. Kuhn, Widian K. Jubair, Biniam Adane, Charles A. Dinarello
Publikováno v:
Haematologica, 105, 3, pp. 585-597
Haematologica, 105, 585-597
Haematologica
Haematologica, 105, 585-597
Haematologica
Contains fulltext : 229479.pdf (Publisher’s version ) (Open Access) Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation and progressive destruction of joint tissue. It is also characterized by aberra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acef298856716274bba72c9b4280cf3f
https://hdl.handle.net/2066/229479
https://hdl.handle.net/2066/229479
Autor:
Jorge Di Paola, Monica Ransom, Kent Riemondy, Peter Kabos, Rui Fu, Jessica Finlay-Schultz, Austin E. Gillen, Gregory Kirkpatrick, Carol A. Sartorius, Christopher Alderman, Jay R. Hesselberth
Publikováno v:
Nucleic Acids Research
Single-cell RNA sequencing (scRNA-seq) methods generate sparse gene expression profiles for thousands of single cells in a single experiment. The information in these profiles is sufficient to classify cell types by distinct expression patterns but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046a90d5aca6e528c3b3109e1c96035c
Autor:
H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Weihe Zhang, Douglas K. Graham, Christopher T. Cummings, Kurtis D. Davies, Dehui Zhang, Deborah DeRyckere, Gregory Kirkpatrick
Publikováno v:
Molecular Cancer Therapeutics. 14:2014-2022
Treatment of non–small cell lung cancer (NSCLC) has been transformed by targeted therapies directed against molecular aberrations specifically activated within an individual patient's tumor. However, such therapies are currently only available agai
Autor:
Stephen V. Frye, H. Shelton Earp, Craig T. Jordan, Michael A. Stashko, Sean Rinella, Weihe Zhang, Douglas K. Graham, Dehui Zhang, Lauren S. Page, Qi Wei, Deborah DeRyckere, Alisa B. Lee-Sherick, Gregory Kirkpatrick, Amanda A. Hill, Xiaodong Wang, Jing Liu, Kelly Menachof
Publikováno v:
Oncotarget
Mer and Flt3 receptor tyrosine kinases have been implicated as therapeutic targets in acute myeloid leukemia (AML). In this manuscript we describe UNC1666, a novel ATP-competitive small molecule tyrosine kinase inhibitor, which potently diminishes Me
Autor:
Deborah DeRyckere, Michael A. Stashko, Alisa B. Lee-Sherick, Catherine C. Smith, Weihe Zhang, Elisabeth A. Lasater, Xiaodong Wang, Katherine A. Minson, Douglas K. Graham, Dmitri Kireev, Clara Libbrecht, Gregory Kirkpatrick, Craig T. Jordan, H. Shelton Earp, Neil P. Shah, Stephen V. Frye, Madeline G. Huey
Publikováno v:
JCI insight, vol 1, iss 3
JCI Insight, Vol 1, Iss 3 (2016)
JCI Insight, Vol 1, Iss 3 (2016)
FMS-like tyrosine kinase 3–targeted (FLT3-targeted) therapies have shown initial promise for the treatment of acute myeloid leukemia (AML) expressing FLT3-activating mutations; however, resistance emerges rapidly. Furthermore, limited options exist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd62d2b5bb3a7d86944fb64cc117f353
https://escholarship.org/uc/item/12m0445m
https://escholarship.org/uc/item/12m0445m
Autor:
Rabe Jennifer, Biniam Adane, Eric M. Pietras, Giovanny Hernandez, Jorge DiPaola, Leila Noetzli, Michael Holers, Susan Kuldanek, Nirmal K. Banda, Gregory Kirkpatrick, Craig T. Jordan, Sumitra Acharya
Publikováno v:
Experimental Hematology. 53:S71
Autor:
Rachel M. A. Linger, Deborah DeRyckere, Douglas K. Graham, Gregory Kirkpatrick, Kurtis D. Davies, Rebecca A. Cohen, Christopher T. Cummings, H. Shelton Earp, Susan Sather
Publikováno v:
Oncotarget
// Christopher T. Cummings 1,* , Rachel M.A. Linger 1,4,* , Rebecca A. Cohen 1 , Susan Sather 1 , Gregory D. Kirkpatrick 1 , Kurtis D. Davies 1 , Deborah DeRyckere 1 , H. Shelton Earp 2,3 and Douglas K. Graham 1 1 Department of Pediatrics, Section of
Autor:
Giovanny Hernandez, Courtney L. Jones, James Hagman, Xiayuan Liang, Eric M. Pietras, Jesse W. Rowley, Susan Fosmire, Christopher C. Porter, Courtney J. Fleenor, Jorge Di Paola, Dmitry Baturin, Leila Noetzli, Gregory Kirkpatrick, Welsh Seth, Craig T. Jordan
Publikováno v:
Blood. 128:2655-2655
Recent studies from our group and others have revealed a role for ETV6 germline mutations in the predisposition to ALL. Although ETV6 is among the most commonly mutated genes in ALL, its mechanistic role in leukemogenesis remains unclear. ETV6 is an