Výsledky vyhledávání - "Gregory Kaler"

Organic Anion Transporter 3 Contributes to the Regulation of Blood Pressure

Autor: Sanjay K. Nigam, Gregory Kaler, Wei Wu, Timo Rieg, Volker Vallon, Sushil K. Mahata, Gary Siuzdak, Satish A. Eraly, Sun-Young Ahn, William R. Wikoff, Bruce A. Barshop, Nitish R. Mahapatra, Jon A. Gangoiti, David M. Truong

Publikováno v: Journal of the American Society of Nephrology. 19:1732-1740

Renal organic anion transporters (OAT) are known to mediate the excretion of many drugs, but their function in normal physiology is not well understood. In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a771a1df90f4eff5789ce5c620f1d6f
https://doi.org/10.1681/asn.2008020180

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Multi-level Analysis of Organic Anion Transporters 1, 3, and 6 Reveals Major Differences in Structural Determinants of Antiviral Discrimination

Autor: Akash Khandelwal, Sanjay K. Nigam, Peter W. Swaan, David M. Truong, Gregory Kaler

Publikováno v: Journal of Biological Chemistry. 283:8654-8663

Long-term exposure to antivirals is associated with serious cellular toxicity to the kidney and other tissues. Organic anion transporters (OATs) are believed to mediate the cellular uptake, and hence cytotoxicity, of many antivirals. However, a syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84a51d5210ab6b5b6a7ddba16303729
https://doi.org/10.1074/jbc.m708615200

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Structural Variation Governs Substrate Specificity for Organic Anion Transporter (OAT) Homologs

Autor: Megha Nagle, Peter W. Swaan, David M. Truong, Akash Khandelwal, Satish A. Eraly, Gregory Kaler, Sanjay K. Nigam

Publikováno v: Journal of Biological Chemistry. 282:23841-23853

Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c526d60502799f399e038f40d451be42
https://doi.org/10.1074/jbc.m703467200

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Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions

Autor: David M. Truong, Megha Nagle, Darren W. Logan, Gregory Kaler, Wei Wu, Satish A. Eraly, Sanjay K. Nigam, Derina E. Sweeney

Publikováno v: Biochemical and Biophysical Research Communications. 351:872-876

We have characterized the expression of organic anion transporter 6, Oat6 (slc22a20), in olfactory mucosa, as well as its interaction with several odorant organic anions. In situ hybridization reveals diffuse Oat6 expression throughout olfactory epit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ffbbf81fa3d2291c9a4bc977520335
https://doi.org/10.1016/j.bbrc.2006.10.136

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Assay Principle for Modulators of Protein−Protein Interactions and Its Application to Non-ATP-Competitive Ligands Targeting Protein Kinase A

Autor: S. Adrian Saldanha, Gregory Kaler, Howard B. Cottam, Ruben Abagyan, Susan S. Taylor

Publikováno v: Analytical Chemistry. 78:8265-8272

Targeting sites that modulate protein-protein interactions represents an ongoing challenge for drug discovery. We have devised an assay principle, named ligand-regulated competition (LiReC), in an effort to find non-ATP competitive small-molecule reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b160cef53b575545d27bd6e03fa1d9a
https://doi.org/10.1021/ac061104g

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Decreased Renal Organic Anion Secretion and Plasma Accumulation of Endogenous Organic Anions in OAT1 Knock-out Mice

Autor: Megha Nagle, Duke A. Vaughn, Kerstin Richter, Sanjay K. Nigam, Gregory Kaler, David M. Truong, Satish A. Eraly, Jon A. Gangoiti, Timo Rieg, Bruce A. Barshop, Volker Vallon, Julio Cesar Martins Monte, Jeffrey M. Long

Publikováno v: Journal of Biological Chemistry. 281:5072-5083

The "classical" organic anion secretory pathway of the renal proximal tubule is critical for the renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a large number of commonly prescribed drugs among other significant s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6108735eb99dae08555317ad79b2bf5a
https://doi.org/10.1074/jbc.m508050200

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Serotonin Antagonist Profiling on 5HT2A and 5HT2C Receptors by Nonequilibrium Intracellular Calcium Response Using an Automated Flow-Through Fluorescence Analysis System, HT-PSÒ 100

Autor: Alex Okun, Gregory Kaler, Michael Otto, Ilya Okun

Publikováno v: SLAS Discovery. 7:291-301

Characterization of the potencies of agonists and antagonists in cell-based assays can be complicated by nonequilibrium conditions of functional response. We assessed the potencies of a series of serotonin (5HT) antagonists by inhibition of intracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec0565c62ca92424a502ecd07001fe9
https://doi.org/10.1177/108705710200700313

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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members

Autor: Gregory, Kaler, David M, Truong, Akash, Khandelwal, Megha, Nagle, Satish A, Eraly, Peter W, Swaan, Sanjay K, Nigam

Publikováno v: The Journal of biological chemistry. 282(33)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd93c87a93615d52f75d5867f801e246
https://pubmed.ncbi.nlm.nih.gov/17553798

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