Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gregory J. Simand"'
Autor:
Gregory Simand, Gregory J. Simand, Evan Hess, Linghai Kong, Nicholas J. Raddatz, Matthew M Hurley, Brian Maunze, SuJean Choi, Aron M. Geurts, David A. Baker
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 76-76 (2022)
OBJECTIVES/GOALS: We aim to determine whether non-neuronal, non-synaptic glutamate signaling mechanisms can be targeted to produce highly specific, narrow changes in brain function that would benefit CNS disorders. To do this, we investigated cogniti
Externí odkaz:
https://doaj.org/article/f0d5bc85c7a9421885ab6fab76126b3b
Autor:
Lisa Y. Maeng, Dekel Rosenfeld, Gregory J. Simandl, Florian Koehler, Alexander W. Senko, Junsang Moon, Georgios Varnavides, Maria F. Murillo, Adriano E. Reimer, Aaron Wald, Polina Anikeeva, Alik S. Widge
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Exposure to stressful or traumatic stimuli may alter hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal-medullary (SAM) reactivity. This altered reactivity may be a component or cause of mental illnesses. Dissecting these mechanisms requir
Externí odkaz:
https://doaj.org/article/a2ceaad84521430da62e2e5ac40a4770
Autor:
Amanda R. de Oliveira, Adriano E. Reimer, Gregory J. Simandl, Sumedh S. Nagrale, Alik S. Widge
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The orbitofrontal cortex–ventromedial striatum (OFC–VMS) circuitry is widely believed to drive compulsive behavior. Hyperactivating this pathway in inbred mice produces excessive and persistent self-grooming, which has been considered a
Externí odkaz:
https://doaj.org/article/811f3a9517ea44bbaaaa39ebad2210a7
Autor:
Gregory Simandl, Gregory J. Simandl, Evan Hess, Linghai Kong, Nicholas J. Raddatz, Matthew M. Hurley, Brian Maunze, SuJean Choi, Aaron M. Geurts, David A. Baker
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 145-145 (2023)
OBJECTIVES/GOALS: We aim to discover safer and more effective therapeutics for CNS disorders. Current therapeutic development is hindered by dosing out drugs for safe consumption. By identifying proteins with narrow functional roles in the brain (i.e
Externí odkaz:
https://doaj.org/article/e95a333379c64267a47095434505eef3