Výsledky vyhledávání - "Gregory J. Riggins"

Akademický článek

Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness

Autor: Natalie S. Joe, Inês Godet, Nubaira Milki, Noor U. I. Ain, Harsh H. Oza, Gregory J. Riggins, Daniele M. Gilkes

Publikováno v: Breast Cancer Research, Vol 24, Iss 1, Pp 1-18 (2022)

Abstract Breast cancer is the most diagnosed cancer among women. Approximately 15–20% of all breast cancers are highly invasive triple-negative breast cancer (TNBC) and lack estrogen, progesterone, and ERBB2 receptors. TNBC is challenging to treat

Externí odkaz: https://doaj.org/article/7cb06462f9314d5ba5823989757985df

Zobrazit plný text záznamu

Akademický článek

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

Autor: Yuxiang Wang, Jie Yang, Aaron T. Wild, Wei H. Wu, Rachna Shah, Carla Danussi, Gregory J. Riggins, Kasthuri Kannan, Erik P. Sulman, Timothy A. Chan, Jason T. Huse

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

ATRX deficiency is linked to genomic stability in cancer cells. Here, the authors show that ATRX inactivation induces G-quadruplex formation, leading to genome-wide DNA damage, and the use of G-quadruplex stabilisers can be exploited therapeutically

Externí odkaz: https://doaj.org/article/e932ee13e3f2482abf203bff31b2b9b3

Zobrazit plný text záznamu

Akademický článek

Author Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Autor: Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick F. Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)

Externí odkaz: https://doaj.org/article/23519f12f351443dabd9173f3e5f56f7

Zobrazit plný text záznamu

Akademický článek

Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Autor: Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.

Externí odkaz: https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b

Zobrazit plný text záznamu

Akademický článek

Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma

Autor: Kanlayanee Sawanyawisuth, Ph.D., Nattawat Tantapotinan, Ratthaphol Kraiklang, Anucha Puapairoj, Chaisiri Wongkham, Gregory J. Riggins, Sopit Wongkham

Publikováno v: Annals of Hepatology, Vol 15, Iss 1, Pp 71-81 (2016)

Background and aim. Trophoblast cell surface antigen 2 (TROP2) or tumor-associated calcium signal transducer 2 (TACSTD2) is a 36-kDa type I transmembrane glycoprotein and exerts dual functions as an oncogene and tumor suppressor in cancer cells. In t

Externí odkaz: https://doaj.org/article/5af2a367c4f740d7a41eae6ac24c760a

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání