Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Gregory J. Hollingworth"'
1
Structure-activity relationship studies on divalent naphthalene diimide G quadruplex ligands with anticancer and antiparasitic activity
Autor: Manuel Pérez-Soto, Pablo Peñalver, Steven T.G. Street, Dora Weenink, Michael P. O'Hagan, Javier Ramos-Soriano, Y. Jennifer Jiang, Gregory J. Hollingworth, M. Carmen Galan, Juan C. Morales
Publikováno v: Pérez-Soto, M, Peñalver, P, Street, S T G, Weenink, D, O'Hagan, M P, Ramos-Soriano, J, Jiang, Y J, Hollingworth, G J, Galan, M C & Morales, J C 2022, ' Structure-activity relationship studies on divalent naphthalene diimide G quadruplex ligands with anticancer and antiparasitic activity ', Bioorganic & Medicinal Chemistry, vol. 71, 116946 . https://doi.org/10.1016/j.bmc.2022.116946
Naphthalene diimide (NDI) is a central scaffold that has been commonly used in the design of G-quadruplex (G4) ligands. Previous work revealed notable anticancer activity of a disubstituted N-methylpiperazine propyl NDI G4 ligand. Here, we explored s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b98fb7e677ed04b99769a10d2f5408
https://research-information.bris.ac.uk/ws/files/334603680/Full_text_PDF_final_published_version_.pdf
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2
Real-Time Imaging and Quantification of Peptide Uptake
Autor: Hacer, Karatas, Tamara, Maric, Pier Luca, D'Alessandro, Aleksey, Yevtodiyenko, Thomas, Vorherr, Gregory J, Hollingworth, Elena A, Goun
Publikováno v: ACS chemical biology. 14(10)
Peptides constitute an important class of drugs for the treatment of multiple metabolic, oncological, and neurodegenerative diseases, and several hundred novel therapeutic peptides are currently in the preclinical and clinical stages of development.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c4a04b6c2202e5b6b48d85b5667cb86
https://pubmed.ncbi.nlm.nih.gov/31498986
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5
ChemInform Abstract: Preparation and Reactions of 3- and 4-Tributylstannyl-2-(5H)-furanones: Preparation of Aryl Furanones
Autor: Gregory J. Hollingworth, Joseph B. Sweeney
Publikováno v: ChemInform. 24
3- and 4-trialkylstannylfuranones (2) and (3) have been prepared by an interesting desulphurative stannylation reaction; 3- and 4-substituted 2-(5H)-Furanones (12) and (13) may be prepared via palladium-catalysed cross coupling of (2) and (3) with ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::546b878564d1b6eec7aed90eec6c8dc6
https://doi.org/10.1002/chin.199315171
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9
ChemInform Abstract: Synthesis of Cleviolide and the Scobinolides
Autor: Gregory J. Hollingworth, Joseph B. Sweeney, Alexandre M. E. Richecoeur
Publikováno v: ChemInform. 28
The palladium-catalysed cross-coupling reaction of 4-tributylstannylfuran-2(5H)-one 3 with 1-iodo-4-methylpent-3-en-1-yne 4a gives the natural product cleviolide; from this substance may be prepared both (Z)- and (E)-isomers of scobinolide.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac32b89529741bd772dc3e1120c0c947
https://doi.org/10.1002/chin.199723214
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10
Preparation and reactions of 3- and 4-tributylstannyl-2-(5H)-furanones: Preparation of aryl furanones
Autor: Gregory J. Hollingworth, Joseph B. Sweeney
Publikováno v: Tetrahedron Letters. 33:7049-7052
3- and 4-trialkylstannylfuranones (2) and (3) have been prepared by an interesting desulphurative stannylation reaction; 3- and 4-substituted 2-(5H)-Furanones (12) and (13) may be prepared via palladium-catalysed cross coupling of (2) and (3) with ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09e6d00822ea810487799dc4b881b1fb
https://doi.org/10.1016/s0040-4039(00)60930-9
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