Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gregory J. Gabriel"'
Publikováno v:
Angewandte Chemie International Edition. 50:6147-6150
The unique ability of cell-penetrating peptides (CPPs), also known as protein transduction domains, to navigate across the nonpolar biological membrane has been under intense investigation. In vitro studies have shown that multiple mechanisms are ava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2bdfc3f457ab14ad9b613ad5467c03
https://doi.org/10.1002/anie.201101535
https://doi.org/10.1002/anie.201101535
Autor:
Gregory N. Tew, Joanna G. Pool, Gregory J. Gabriel, E. Bryan Coughlin, Jeffrey M. Dabkowski, Murugappan Muthukumar, Abhigyan Som
Publikováno v:
Langmuir. 24:12489-12495
Antimicrobial polynorbornenes composed of facially amphiphilic monomers have been previously reported to accurately emulate the antimicrobial activity of natural host-defense peptides (HDPs). The lethal mechanism of most HDPs involves binding to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb100cb818851007ed571c42a616a07
https://doi.org/10.1021/la802232p
https://doi.org/10.1021/la802232p
Publikováno v:
Journal of the American Chemical Society, Vol. 130, No 31 (2008) pp. 10338-10344
Journal of the American Chemical Society
Journal of the American Chemical Society
We introduce guanidinium-containing synthetic polymers based on polyguanidino-oxanorbornenes (PGONs) as anion transporters in lipid bilayers that can be activated and inactivated by chemical stimulation. According to fluorogenic anion export experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7568c8833124a870e9694f0268c768ad
https://doi.org/10.1021/ja802587j
https://doi.org/10.1021/ja802587j
Autor:
Gregory N. Tew, Gregory J. Gabriel
Publikováno v:
Org. Biomol. Chem.. 6:417-423
The promise of proteomics to provide a vast library of protein structural data is exciting to scientists desiring an unprecedented understanding of the relationship between protein structure and function. This powerful knowledge will provide insight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6cf2cc595d6f9ed9ebeab48bf01916
https://doi.org/10.1039/b714490n
https://doi.org/10.1039/b714490n
Publikováno v:
Materials Science and Engineering: R: Reports. 57:28-64
Infectious disease is a critically important global healthcare issue. In the U.S. alone there are 2 million new cases of hospital-acquired infections annually leading to 90,000 deaths and 5 billion dollars of added healthcare costs. Couple these numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6731caf8521ccbb7e071c92f20a363
https://doi.org/10.1016/j.mser.2007.03.002
https://doi.org/10.1016/j.mser.2007.03.002
Publikováno v:
Journal of the American Chemical Society. 127:2637-2640
Proteins can adopt helical and sheet-type secondary structures that depend on their primary sequence of amino acids. Nonnatural foldamers have been developed to emulate these protein structures as well as investigate various types of noncovalent inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630ae378cffe63aa5328cd5952558c8a
https://doi.org/10.1021/ja046722y
https://doi.org/10.1021/ja046722y
Publikováno v:
Inorganic Chemistry. 44:40-44
Because of the importance of the hydroxamic acid functional group in zinc protease inhibitors, we have measured the stability constants of the ternary complex LMG, where L is series of tridentate and tetradentate ligands containing amino, carboxylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bfbce9d7ef3dec6a7301fac129748d
https://doi.org/10.1021/ic0493090
https://doi.org/10.1021/ic0493090
Autor:
Rolf I. Carlson, Gregory J. Gabriel, Waihong Chung, Arihiro Aihara, Qiushi Lin, Qi Tang, Chiung-Kuei Huang, Xiaoqun Dong, Xuesong Chen, Mark Olsen, Yu Li, Jack R. Wands, Christina Nadolny
Publikováno v:
Oncotarget
Pancreatic cancer (PC) is one of the leading causes of cancer related deaths due to aggressive progression and metastatic spread. Aspartate β-hydroxylase (ASPH), a cell surface protein that catalyzes the hydroxylation of epidermal growth factor (EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b626685bc12922628495d18f9c9f2b
https://pubmed.ncbi.nlm.nih.gov/31762945
https://pubmed.ncbi.nlm.nih.gov/31762945
Autor:
Nancy Bae, Guanqun Zheng, Lu Zhou, Chuan He, Mark Olsen, Matthew E. Booher, Thomas Cox, Paulina Iacoban, Leah Mary Tribbey, Joie Rowles, Gloria Z. Wang, Gregory J. Gabriel
We describe the rationale for and the synthesis of a new class of compounds utilizing a modular approach that are designed to mimic ascorbic acid and to inhibit 2-oxoglutarate-dependent hydroxylases. Preliminary characterization of one of these compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6612f1803f5d46cdaa53a4ab806b46
https://europepmc.org/articles/PMC4140589/
https://europepmc.org/articles/PMC4140589/
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 29(13)
We report the facile one-pot single-phase syntheses of silver nanoparticles stabilized by norbornene type cationic polymers. Silver nanoparticles (AgNPs) stabilized by polyguanidino oxanorbornenes (PG) at 5 and 25 kDa and polyamino oxanorbornenes (PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321c317c6d1f95b1baaa1fc7bee828c8
https://pubmed.ncbi.nlm.nih.gov/23461821
https://pubmed.ncbi.nlm.nih.gov/23461821