Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gregory J. Carven"'
Autor:
Alain Beck, Christine Nowak, Deborah Meshulam, Kristina Reynolds, David Chen, Dennis B. Pacardo, Samantha B. Nicholls, Gregory J. Carven, Zhenyu Gu, Jing Fang, Dongdong Wang, Amit Katiyar, Tao Xiang, Hongcheng Liu
Publikováno v:
Antibodies, Vol 11, Iss 4, p 73 (2022)
Since the first approval of the anti-CD3 recombinant monoclonal antibody (mAb), muromonab-CD3, a mouse antibody for the prevention of transplant rejection, by the US Food and Drug Administration (FDA) in 1986, mAb therapeutics have become increasingl
Externí odkaz:
https://doaj.org/article/cd3983fa158a4c4bb3c5862b56b24711
Autor:
Laurence Fayadat-Dilman, Christine Andrews, Gulesi Ayanoglu, Liming Liu, Robert A. Kastelein, Aarron T. Willingham, Sabine Le Saux, Svetlana Sadekova, Dan Malashock, Hans van Eenennaam, Sophie Li, Ying Yu, Soonmo Peter Kang, Beth Hutchins, Andrea van Elsas, John Dulos, Rene De Waal Malefyt, Julie Lee, Frederique M. Poulet, Gregory J. Carven, Constance Cullen, Gary C. Starling, Mark Hsieh, Danuta J. Herzyk, Michel Streuli, Mark A. McCoy, George Soder
Publikováno v:
Molecular Cancer Therapeutics. 19:1298-1307
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Autor:
Frederick C. Streich, Susan C Lin, Samantha B. Nicholls, Ryan Faucette, Justin W. Jackson, Chris J Boston, Capili Allan, Anastasia Nikiforov, Kevin B. Dagbay, Erin Treece, Gregory J. Carven
Publikováno v:
The Journal of Biological Chemistry
Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in muscle wasting diseases. SRK-015
Autor:
Shaun M. Cote, Gregory J. Carven, Justin W. Jackson, Stefan Wawersik, Michelle Pirruccello-Straub
Publikováno v:
Slas Discovery
Myostatin, a member of the transforming growth factor β (TGFβ) superfamily, is a key regulator of skeletal muscle mass and a therapeutic target for muscle wasting diseases. We developed a human monoclonal antibody, SRK-015, that selectively binds t
Autor:
Nicole Danek, Ashish Kalra, Stefan Wawersik, Ryan R. Faucette, Gregory J. Carven, Constance Martin, Alan Buckler, Anastasia Nikiforov, Frederick C. Streich, Christopher Brueckner, Pichai Raman, Lin Susan, Kevin B. Dagbay, Christopher Littlefield, Justin W. Jackson, Christopher Chapron, Francis T. Danehy, Thomas Schurpf, Christopher Boston, Allison Simpson, Abhishek Datta, Capili Allan
Publikováno v:
Science Translational Medicine. 12
Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many patients do not respond to anti-programmed cell death-1 (PD-1) due to primary or acquired resistance. Human tumor profiling and preclinical studies in tumor models hav
Autor:
Beth, Hutchins, Gary C, Starling, Mark A, McCoy, Danuta, Herzyk, Frederique M, Poulet, John, Dulos, Liming, Liu, Soonmo Peter, Kang, Laurence, Fayadat-Dilman, Mark, Hsieh, Christine L, Andrews, Gulesi, Ayanoglu, Constance, Cullen, Rene de Waal, Malefyt, Robert A, Kastelein, Sabine Le, Saux, Julie, Lee, Sophie, Li, Dan, Malashock, Svetlana, Sadekova, George, Soder, Hans, van Eenennaam, Aarron, Willingham, Ying, Yu, Michel, Streuli, Gregory J, Carven, Andrea, van Elsas
Publikováno v:
Molecular cancer therapeutics. 19(6)
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Autor:
A. Donovan, Capili Allan, K. J. Turner, Michelle Pirruccello-Straub, K. Long, W. McConaughy, N. K. Mahanthappa, Stefan Wawersik, Gregory J. Carven, L. Salta, C. Boston, M. T. Webster, Justin W. Jackson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Many growth factors are intimately bound to the extracellular matrix, with regulated processing and release leading to cellular stimulation. Myostatin and GDF11 are closely related members of the TGFβ family whose activation requires two proteolytic
Autor:
Christopher Littlefield, Ashish Kalra, Anastasia Nikiforov, Christopher Boston, Allison Simpson, Constance Martin, Stefan Wawersik, Abhishek Datta, Christopher Chapron, Francis T. Danehy, Thomas Schurpf, Gregory J. Carven, Lin Susan, Justin W. Jackson, Alan Buckler
Publikováno v:
Cancer Research. 79:4090-4090
Despite the clinical breakthroughs achieved by checkpoint blockade therapy (CBT), a majority of patients treated with PD-(L)1 inhibitors fail to respond due to primary or acquired resistance. TGFβ signaling has recently been implicated as a mechanis
Autor:
Jun Kuai, Lidia Mosyak, Michael Cain, Robert Arch, Nicholas Pullen, Gregory J. Carven, Shinji Ogawa, Jon Brooks, Dirk Ponsel, Zhiyong Yang, Robert Rauchenberger, Edward R. Lavallie, Tetsuya Ishino, May Tam
Publikováno v:
Biochemistry. 54(10)
Platelet derived growth factor-BB (PDGF-BB) is an important mitogen and cell survival factor during development. PDGF-BB binds PDGF receptor-β (PDGFRβ) to trigger receptor dimerization and tyrosine kinase activation. We present the pharmacological
Publikováno v:
Antibody-Drug Conjugates ISBN: 9783319130804
Antibody–drug conjugates (ADCs) represent an increasing proportion of therapeutics in preclinical and clinical development for the treatment of oncology indications. ADC-based therapies are attractive due to their potential to increase efficacy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b79f2119c1eeee34f40ad59b924317c
https://doi.org/10.1007/978-3-319-13081-1_3
https://doi.org/10.1007/978-3-319-13081-1_3