Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Gregory J. Bix"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Perlecan is a 500 kDa proteoglycan residing in the extracellular matrix of endothelial basement membranes with five distinct protein domains and three heparan sulfate chains. The complex structure of perlecan and the interaction it has with its local
Externí odkaz:
https://doaj.org/article/801131b510b2466faea403c5e872c462
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Injuries and disorders of the central nervous system (CNS) present a particularly difficult challenge for modern medicine to address, given the complex nature of the tissues, obstacles in researching and implementing therapies, and barriers to transl
Externí odkaz:
https://doaj.org/article/34cb1a91e96b429ea45ec8590eafdbb9
Autor:
Ibolya Rutkai, Meredith G. Mayer, Linh M. Hellmers, Bo Ning, Zhen Huang, Christopher J. Monjure, Carol Coyne, Rachel Silvestri, Nadia Golden, Krystle Hensley, Kristin Chandler, Gabrielle Lehmicke, Gregory J. Bix, Nicholas J. Maness, Kasi Russell-Lodrigue, Tony Y. Hu, Chad J. Roy, Robert V. Blair, Rudolf Bohm, Lara A. Doyle-Meyers, Jay Rappaport, Tracy Fischer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
COVID-19 can result in neurological manifestations and animal models could provide insights into the mechanisms. Here, the authors describe neuroinflammation, microhemorrhages and brain hypoxia in SARS-CoV-2 infected non-human primates, including in
Externí odkaz:
https://doaj.org/article/0c1be27d8686492ebe212a4588149d65
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 279-286 (2022)
Abstract Acute ischemic stroke continues to devastate millions of individuals worldwide. Current treatments work to restore blood flow but not rescue affected tissue. Our goal was to develop a combination of neuroprotective agents administered intra
Externí odkaz:
https://doaj.org/article/c904ea02b57c4b0eb0f3ff49f05df6ed
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, lymphoreticular, bone and bone marrow stroma and in neural tis
Externí odkaz:
https://doaj.org/article/174004da8a704b05b63354a3ffc3ca0e
Autor:
Kathleen E. Salmeron, Michael E. Maniskas, Danielle N. Edwards, Raymond Wong, Ivana Rajkovic, Amanda Trout, Abir A. Rahman, Samantha Hamilton, Justin F. Fraser, Emmanuel Pinteaux, Gregory J. Bix
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Stroke remains a leading cause of death and disability worldwide despite recent treatment breakthroughs. A primary event in stroke pathogenesis is the development of a potent and deleterious local and peripheral inflammatory respo
Externí odkaz:
https://doaj.org/article/273b8e65e82841ef908986946a065ab4
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Early in the development of multiple sclerosis (MS) and its mouse model experimental autoimmune encephalomyelitis (EAE), vascular integrity is compromised. This is accompanied by a marked vascular remodeling response, though it is currently
Externí odkaz:
https://doaj.org/article/94b9874d96744978a9d055bd5e825c49
Autor:
Carolina Dalmasso, Alejandro R. Chade, Mariela Mendez, Jorge F. Giani, Gregory J. Bix, Kuey C. Chen, Analia S. Loria
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/124e672320134723a144f3ee3802580b
Autor:
Carolina Dalmasso, Alejandro R. Chade, Mariela Mendez, Jorge F. Giani, Gregory J. Bix, Kuey C. Chen, Analia S. Loria
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Environmental stress during early life is an important factor that affects the postnatal renal development. We have previously shown that male rats exposed to maternal separation (MatSep), a model of early life stress, are normotensive but display a
Externí odkaz:
https://doaj.org/article/312347319bdd4216ada7dcf87909b851
Autor:
Danielle N. Edwards, Gregory J. Bix
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to t
Externí odkaz:
https://doaj.org/article/c9b9e2759ed74c8a9ca9e538686dadf0