Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gregory J. Aune"'
Autor:
Haihui Pan, Kunhua Qin, Zhanyong Guo, Yonggang Ma, Craig April, Xiaoli Gao, Thomas G. Andrews, Alex Bokov, Jianhua Zhang, Yidong Chen, Susan T. Weintraub, Jian-Bing Fan, Degeng Wang, Yanfen Hu, Gregory J. Aune, Merry L. Lindsey, Rong Li
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 79-85 (2014)
Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across multicellular genomes. However, the physiological impact of NELF on tissue homeostasis remains uncle
Externí odkaz:
https://doaj.org/article/68c97ea5df3a40368658fb58edf0679e
Autor:
Trevi A. Mancilla, Gregory J. Aune
Publikováno v:
Journal of Clinical and Translational Science, Vol 1, Pp 7-7 (2017)
OBJECTIVES/SPECIFIC AIMS: Our research strives to understand the pathophysiology of doxorubicin cardiotoxicity, focusing on the understudied nonmyocyte cardiac cells. Our understanding will enable researchers to develop protective or alternative ther
Externí odkaz:
https://doaj.org/article/27daf2c6ffe7419d93a4d3446dfe2d38
Autor:
Andrew D. Meyer, Tyler B. Hughes, Anjana R. Rishmawi, Patty Heard, Shafqat Shah, Gregory J. Aune
Publikováno v:
Thrombosis Research. 226:100-106
Autor:
Brian S. Iskra, Logan Davis, Henry E. Miller, Yu-Chiao Chiu, Alexander J. R. Bishop, Yidong Chen, Gregory J. Aune
Publikováno v:
Am J Physiol Heart Circ Physiol
Childhood cancer survivors (CCSs) face lifelong side effects related to their treatment with chemotherapy. Anthracycline agents, such as doxorubicin (DOX), are important in the treatment of childhood cancers but are associated with cardiotoxicity. Ca
Autor:
Leontien C. M. Kremer, Eugene Suh, Bradley Benson, Gregory J. Aune, Monica Muraca, Edit Bardi, Daniel A. Mulrooney, Roderick Skinner, Gill Levitt, Liane Lockwood, Chris Plummer, Renée L. Mulder, Louis S. Constine, W. Hamish B. Wallace, Eva Frey, Christina Schindera, Ming H. Chen, Melissa M. Hudson, Emily S. Tonorezos, Elvira C. van Dalen, Ulrike Hennewig, Helena J H van der Pal, Jutta Bergler-Klein, Ulla Martinsson, Katrin Scheinemann, Matthew J. Ehrhardt
Publikováno v:
European Journal of Cancer. 156:127-137
Background Coronary artery disease (CAD) is a concerning late outcome for cancer survivors. However, uniform surveillance guidelines are lacking. Aim To harmonise international recommendations for CAD surveillance for survivors of childhood, adolesce
Autor:
Shuang Chen, M. Noval Rivas, M Gorelik, Jean L. Patterson, Masanori Abe, Timothy R. Crother, Gregory J. Aune, Youngho Lee, Thomas Andrews, Leyla R. Davis, Moshe Arditi
Publikováno v:
Clinical and Experimental Immunology
Summary Kawasaki disease (KD) vasculitis is an acute febrile illness of childhood characterized by systemic vasculitis of unknown origin, and is the most common cause of acquired heart disease among children in the United States. While histological e
Autor:
Kathryn Crouch, Logan Davis, Nirupama Sabnis, Alexander Pertsemlidis, Laura Rutledge, James Graham, Jason Yustein, Gregory J. Aune
Publikováno v:
Cancer Research. 82:375-375
Purpose: Anthracyclines effectively treat many pediatric cancers, but their use is limited by cardiotoxicity and new approaches to mitigate anthracycline-induced cardiac damage are urgently needed. Nanoparticle drug delivery is one solution to mainta
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238856 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238856 (2020)
Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, the vast majority of long-term childhood cancer survivors will develop a chronic health condition caused
Autor:
Bishop Ar, Gregory J. Aune, Brian S. Iskra, Leyla R. Davis, Yu-Chiao Chiu, Henry E. Miller, Yi Chen
Cardiac non-myocytes comprise a diverse and crucial cell population in the heart that plays dynamic roles in cardiac wound healing and growth. Non-myocytes broadly fall into four cell types: endothelium, fibroblasts, leukocytes, and pericytes. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553256ddc318c73ab7575c513cb6fd35
Autor:
Joya Chandra, Claudia Alvarez-Florez, Angela Shaw, Keri Schadler, Gregory J. Aune, Brian S. Iskra, Thomas Andrews, Fei Wang, Eugenie S. Kleinerman
Publikováno v:
Journal of Pediatric Hematology/Oncology. 40:208-215
We report the cardioprotective effects of moderate aerobic exercise from parallel pediatric murine models of doxorubicin (Doxo) exposure in non-tumor-bearing immune competent (NTB-IC) mice and tumor-bearing nude mice (TB-NM). In both models, animals