Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Gregory J. Atkins"'
Autor:
Brian J. Sheahan, Gregory J. Atkins
Publikováno v:
Journal of General Virology. 97:1283-1296
Alphaviruses are enveloped viruses with a positive-stranded RNA genome, of the family Togaviridae. In mammals and birds they are mosquito-transmitted and are of veterinary and medical importance. They cause primarily two types of disease: encephaliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a657f0be6e87b328e72ed6ca3e8fd4d
https://doi.org/10.1099/jgv.0.000467
https://doi.org/10.1099/jgv.0.000467
Autor:
Gregory J. Atkins
Publikováno v:
ISRN Virology. 2013:1-22
Alphaviruses are enveloped single-stranded positive sense RNA viruses of the family Togaviridae. The genus alphavirus contains nine viruses, which are of medical, theoretical, or economic importance, and which will be considered. Sindbis virus (SINV)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd95f388821611a2e81f734b06eefde6
https://doi.org/10.5402/2013/861912
https://doi.org/10.5402/2013/861912
Publikováno v:
Neuropathology and Applied Neurobiology. 36:648-660
F. P. Roche, B. J. Sheahan, S. M. O'Mara and G. J. Atkins (2010) Neuropathology and Applied Neurobiology36, 648–660 Semliki Forest virus-mediated gene therapy of the RG2 rat glioma Aims: Glioblastoma multiforme is the most common and most malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::054703271393107cc72f72d762242b9b
https://doi.org/10.1111/j.1365-2990.2010.01110.x
https://doi.org/10.1111/j.1365-2990.2010.01110.x
Publikováno v:
Recent Patents on Anti-Cancer Drug Discovery. 2:159-166
Alphaviruses are positive-strand RNA viruses that are being developed as a high level transient expression vectors. Although most work so far has centered on their use as vaccine vectors, they do have potential as tumor therapy agents. The region of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0320359451acd54cf7020ea723e435b7
https://doi.org/10.2174/157489207780832432
https://doi.org/10.2174/157489207780832432
Publikováno v:
Journal of General Virology. 87:937-947
Major virulence determinants ofSemliki Forest virus(SFV) lie within the non-structural genes that form the replicase complex proteins. Gene exchange between virulent and avirulent viruses has shown that the nsP3 gene, which has essential 5′ conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2cdd928b3c07a9c15dfb6ecb226b9c
https://doi.org/10.1099/vir.0.81406-0
https://doi.org/10.1099/vir.0.81406-0
Publikováno v:
Molecular Therapy. 8:886-894
We have initiated studies to determine the feasibility of employing the Semliki Forest virus (SFV) expression system as a central nervous system (CNS) vector. We investigated the effects of infecting Balb/c mice intranasally (i.n.) with recombinant S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a108cb4b3a17faf4d57f6e7d429eb9
https://doi.org/10.1016/j.ymthe.2003.09.010
https://doi.org/10.1016/j.ymthe.2003.09.010
Publikováno v:
Neuropathology and Applied Neurobiology. 29:553-562
Semliki Forest virus (SFV) infection of mice provides a useful model for the analysis of viral neuropathogenesis. In this study, the roles of interferon (IFN)-gamma and nitric oxide (NO) in the pathogenesis of SFV infection were assessed using mice d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::133e7d47f1613f24d7e9681b6e4a1a2f
https://doi.org/10.1046/j.1365-2990.2003.00492.x
https://doi.org/10.1046/j.1365-2990.2003.00492.x
Publikováno v:
Veterinary Immunology and Immunopathology. 94:185-190
Semliki Forest virus (SFV) infection of mice is a useful model of viral neuropathogenesis in animals and avirulent strains such as SFV-A7 induce immune-mediated demyelination and death of neurones by necrosis and apoptosis. Matrix metalloproteinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7aa3ba8fd9a1d0b8183fc3f995787ca
https://doi.org/10.1016/s0165-2427(03)00082-5
https://doi.org/10.1016/s0165-2427(03)00082-5
Autor:
Gregory J. Atkins, Lisa M. Domegan
Publikováno v:
Journal of General Virology. 83:2135-2143
The induction of cell death by the Therien strain of rubella virus (RVT), and the vaccine RA27/3 strain, was investigated in mixed glial cell cultures derived from the rat CNS. Cell death induction in Vero and rat glial cells by RVT and RA27/3 was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8dca9464f95db4576c68ca40d237b9
https://doi.org/10.1099/0022-1317-83-9-2135
https://doi.org/10.1099/0022-1317-83-9-2135
Autor:
Hugh W Reid, Gregory J. Atkins, Margaret M Morris-Downes, Brian J. Sheahan, Peter Liljeström, Marina N. Fleeton
Publikováno v:
Vaccine. 19:3877-3884
This study has examined the efficacy following intramuscular administration of a recombinant Semliki Forest virus (rSFV) vaccine, encoding the prME and NS1 proteins of louping ill virus (LIV), in sheep. Administration of rSFV-LIV vaccine resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349cfd88cd4fa817a2c8e9b8a4d066fa
https://doi.org/10.1016/s0264-410x(01)00126-8
https://doi.org/10.1016/s0264-410x(01)00126-8