Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Gregory J Pazour"'
Autor:
Richard J B Francis, Jovenal T San Agustin, Heather L Szabo Rogers, Cheng Cui, Julie A Jonassen, Thibaut Eguether, John A Follit, Cecilia W Lo, Gregory J Pazour
Publikováno v:
PLoS Biology, Vol 21, Iss 12, p e3002425 (2023)
Ciliopathies are associated with wide spectrum of structural birth defects (SBDs), indicating important roles for cilia in development. Here, we provide novel insights into the temporospatial requirement for cilia in SBDs arising from deficiency in I
Externí odkaz:
https://doaj.org/article/38fef819639546269aa5ba0887cfbda5
Autor:
Zeineb Bakey, Oscar A Cabrera, Julia Hoefele, Dinu Antony, Kaman Wu, Michael W Stuck, Dimitra Micha, Thibaut Eguether, Abigail O Smith, Nicole N van der Wel, Matias Wagner, Lara Strittmatter, Philip L Beales, Julie A Jonassen, Isabelle Thiffault, Maxime Cadieux-Dion, Laura Boyes, Saba Sharif, Beyhan Tüysüz, Desiree Dunstheimer, Hans W M Niessen, William Devine, Cecilia W Lo, Hannah M Mitchison, Miriam Schmidts, Gregory J Pazour
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010796 (2023)
Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into th
Externí odkaz:
https://doaj.org/article/e3c33751139d4a74a9903b2f1e069797
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009711 (2021)
Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function. Autosomal dominant polycystic kidney disease (ADPKD) is the most comm
Externí odkaz:
https://doaj.org/article/26217d00b81a43db9143c50e1381457f
Autor:
Jillian N Pearring, Jovenal T San Agustin, Ekaterina S Lobanova, Christopher J Gabriel, Eric C Lieu, William J Monis, Michael W Stuck, Lara Strittmatter, Samer M Jaber, Vadim Y Arshavsky, Gregory J Pazour
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006740 (2017)
Arf4 is proposed to be a critical regulator of membrane protein trafficking in early secretory pathway. More recently, Arf4 was also implicated in regulating ciliary trafficking, however, this has not been comprehensively tested in vivo. To directly
Externí odkaz:
https://doaj.org/article/8ed5f6aeb50d4f4f87f5f40e323fea18
Autor:
You Li, Hisato Yagi, Ezenwa Obi Onuoha, Rama Rao Damerla, Richard Francis, Yoshiyuki Furutani, Muhammad Tariq, Stephen M King, Gregory Hendricks, Cheng Cui, Manush Saydmohammed, Dong Min Lee, Maliha Zahid, Iman Sami, Linda Leatherbury, Gregory J Pazour, Stephanie M Ware, Toshio Nakanishi, Elizabeth Goldmuntz, Michael Tsang, Cecilia W Lo
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005821 (2016)
Heterotaxy, a birth defect involving left-right patterning defects, and primary ciliary dyskinesia (PCD), a sinopulmonary disease with dyskinetic/immotile cilia in the airway are seemingly disparate diseases. However, they have an overlapping genetic
Externí odkaz:
https://doaj.org/article/f91ea5dff2e7412f95492d77a7cf09bc
Autor:
John A Follit, Jovenal T San Agustin, Julie A Jonassen, Tingting Huang, Jaime A Rivera-Perez, Kimberly D Tremblay, Gregory J Pazour
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004170 (2014)
The primary cilium is a sensory organelle, defects in which cause a wide range of human diseases including retinal degeneration, polycystic kidney disease and birth defects. The sensory functions of cilia require specific receptors to be targeted to
Externí odkaz:
https://doaj.org/article/19b22dfa3d5940e1b05bf71d9cc56412
Autor:
Cheng Cui, Bishwanath Chatterjee, Thomas P Lozito, Zhen Zhang, Richard J Francis, Hisato Yagi, Lisa M Swanhart, Subramaniam Sanker, Deanne Francis, Qing Yu, Jovenal T San Agustin, Chandrakala Puligilla, Tania Chatterjee, Terry Tansey, Xiaoqin Liu, Matthew W Kelley, Elias T Spiliotis, Adam V Kwiatkowski, Rocky Tuan, Gregory J Pazour, Neil A Hukriede, Cecilia W Lo
Publikováno v:
PLoS Biology, Vol 11, Iss 11, p e1001720 (2013)
Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector proteins, some of which also play essential roles in ciliogenesis, highlighting the long-standing q
Externí odkaz:
https://doaj.org/article/74d38beca1bc443a9a89ee1c2c5aae74
Autor:
John A Follit, Jovenal T San Agustin, Fenghui Xu, Julie A Jonassen, Rajeev Samtani, Cecilia W Lo, Gregory J Pazour
Publikováno v:
PLoS Genetics, Vol 4, Iss 12, p e1000315 (2008)
Eukaryotic cells often use proteins localized to the ciliary membrane to monitor the extracellular environment. The mechanism by which proteins are sorted, specifically to this subdomain of the plasma membrane, is almost completely unknown. Previousl
Externí odkaz:
https://doaj.org/article/81d5eb49e8684cd9960d08ca30f606e5
Publikováno v:
Frontiers in Pediatrics, Vol 6 (2018)
Congenital heart disease (CHD) is one of the most common birth defects, and recent studies indicate cilia-related mutations play a central role in the genetic etiology of CHD. As cilia are also known to have important roles in kidney development and
Externí odkaz:
https://doaj.org/article/7081769008f74cf6a251b78a82c2715a
Autor:
Feng-Qian Li, Mohammed Hoque, Benjamin Cyge, Howard C. Crawford, Eunice N Kim, Randall T. Moon, Ken-Ichi Takemaru, Gregory J. Pazour, Jennifer M. Bailey-Lundberg, Jason C. Hall, Vera Voronina
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Primary cilia protrude from the apical surface of many cell types and act as a sensory organelle that regulates diverse biological processes ranging from chemo- and mechanosensation to signaling. Ciliary dysfunction is associated with a wide array of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98cf53d2044428fda76214478968a38
https://doaj.org/article/887b15da67ff49449b0c627a4c5d0c9c
https://doaj.org/article/887b15da67ff49449b0c627a4c5d0c9c