Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Gregory J Kirkner"'
Autor:
Lidia Schapira, Yue Zheng, Laura Collins, Ann H Partridge, Jeffrey Peppercorn, Virginia F Borges, Rulla M Tamimi, Gregory J Kirkner, Eric P Winer, Kathryn Ruddy, Shoshana M Rosenberg, Philip D Poorvu, Craig Snow, Meghan E Meyer, Steven Come, Ellen Warner, Shari Gelber
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Purpose Compared with older women diagnosed with breast cancer, younger women are more likely to die of breast cancer and more likely to suffer psychosocially in both the short-term and long term. The Young Women’s Breast Cancer Study (YWS) is a mu
Externí odkaz:
https://doaj.org/article/f524706438004f91987fdbc6e69b0465
Autor:
Katsuhiko Nosho, Natsumi Irahara, Kaori Shima, Shoko Kure, Gregory J Kirkner, Eva S Schernhammer, Aditi Hazra, David J Hunter, John Quackenbush, Donna Spiegelman, Edward L Giovannucci, Charles S Fuchs, Shuji Ogino
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3698 (2008)
The CpG island methylator phenotype (CIMP) is a distinct phenotype associated with microsatellite instability (MSI) and BRAF mutation in colon cancer. Recent investigations have selected 5 promoters (CACNA1G, IGF2, NEUROG1, RUNX3 and SOCS1) as surrog
Externí odkaz:
https://doaj.org/article/b43a5ad13b7043638c15c5f89155e7b3
Autor:
Marla Lipsyc-Sharf, Elza C. de Bruin, Katheryn Santos, Robert McEwen, Daniel Stetson, Ashka Patel, Gregory J. Kirkner, Melissa E. Hughes, Sara M. Tolaney, Ann H. Partridge, Ian E. Krop, Charlene Knape, Ute Feger, Giovanni Marsico, Karen Howarth, Eric P. Winer, Nancy U. Lin, Heather A. Parsons
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(22)
PURPOSE To examine the prevalence and dynamics of circulating tumor DNA (ctDNA) and its association with metastatic recurrence in patients with high-risk early-stage hormone receptor–positive breast cancer (HR+ BC) more than 5 years from diagnosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508f57999cac092877c246d9fe1895f3
https://pubmed.ncbi.nlm.nih.gov/35658519
https://pubmed.ncbi.nlm.nih.gov/35658519
Autor:
Adrienne G. Waks, Dewey Kim, Esha Jain, Craig Snow, Gregory J. Kirkner, Shoshana M. Rosenberg, Coyin Oh, Philip D. Poorvu, Kathryn J. Ruddy, Rulla M. Tamimi, Jeffrey Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Elena F. Brachtel, Ellen Warner, Laura C. Collins, Ann H. Partridge, Nikhil Wagle
Publikováno v:
Clinical Cancer Research, 28(11), 2339-2348. American Association for Cancer Research Inc.
Purpose:Young age at breast cancer diagnosis correlates with unfavorable clinicopathologic features and worse outcomes compared with older women. Understanding biological differences between breast tumors in young versus older women may lead to bette
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f910a028d8e11db09bda161f50ae6d
https://doi.org/10.1158/1078-0432.ccr-21-2572
https://doi.org/10.1158/1078-0432.ccr-21-2572
Autor:
Katheryn Santos, Qingchun Jin, Peter G. Miller, Ashka Patel, Gregory J. Kirkner, Janet L. Files, Melissa E. Hughes, Samantha M. Stokes, Nabihah Tayob, Daniel G. Stover, Christopher J. Gibson, Eric P. Winer, Nancy U. Lin, Judy E. Garber, Heather A. Parsons
Publikováno v:
Cancer Research. 82:P3-08
Background. Patients (pts) with metastatic triple negative breast cancer (mTNBC) receive serial cytotoxic chemotherapy regimens, often with cumulative myelosuppressive effects, impairing treatment tolerance. Clonal hematopoiesis of indeterminate pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4571e9a0e345498be4a6b657e7444706
https://doi.org/10.1158/1538-7445.sabcs21-p3-08-01
https://doi.org/10.1158/1538-7445.sabcs21-p3-08-01
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Application of MRD testing to healthy donor cfDNA samples. Patient specific panels designed for 14 different patients were pooled together and applied to cfDNA collected from four different healthy donors. Reported are the number of sites where ctDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ccf7de3b76927d1adaeb53da1b988b
https://doi.org/10.1158/1078-0432.22478906.v1
https://doi.org/10.1158/1078-0432.22478906.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Verification of detection power calculation. Comparison between the predicted detection power of 18 replicates and the actual fraction of those replicates that were called MRD+. 18 independent samples from a 1:100k dilution were probed with a 488 SNV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64af9516783cfdb147d8e83ff11e720a
https://doi.org/10.1158/1078-0432.22478915.v1
https://doi.org/10.1158/1078-0432.22478915.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Early stage breast cancer cohort. (A) Overview of subtype distribution of cohort as well as the timing of blood draws relative to surgery and treatment. (B) REMARK diagram of the early stage breast cancer cohort. (C) Distribution of the number of mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a78d91244c2f15245d1f854b249187
https://doi.org/10.1158/1078-0432.22478927.v1
https://doi.org/10.1158/1078-0432.22478927.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Purpose:Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test for tracking hundreds of patient-specific mutations to detect MRD with a 1,000-fold lower e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22733ab4686b715c65b3b05813aea31f
https://doi.org/10.1158/1078-0432.c.6530084
https://doi.org/10.1158/1078-0432.c.6530084
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Overview schematic of MRD assay. MRD assay workflow from characterizing a primary tumor to determining if a blood draw contains evidence of residual disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109f474d4909e0ad619512094777e084
https://doi.org/10.1158/1078-0432.22478924.v1
https://doi.org/10.1158/1078-0432.22478924.v1