Zobrazeno 1 - 10
of 408
pro vyhledávání: '"Gregory J Hannon"'
Autor:
Sophia A Wild, Ian G Cannell, Ashley Nicholls, Katarzyna Kania, Dario Bressan, CRUK IMAXT Grand Challenge Team, Gregory J Hannon, Kirsty Sawicka
Publikováno v:
eLife, Vol 11 (2022)
Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to therapy has remained cha
Externí odkaz:
https://doaj.org/article/073dea20bdb540c49234376d92acf7b8
Autor:
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Publikováno v:
eLife, Vol 10 (2021)
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents over the course of trea
Externí odkaz:
https://doaj.org/article/8f753d647a7d4f28ad16d9538172ef03
Autor:
Martin H Fabry, Federica A Falconio, Fadwa Joud, Emily K Lythgoe, Benjamin Czech, Gregory J Hannon
Publikováno v:
eLife, Vol 10 (2021)
The PIWI-interacting RNA (piRNA) pathway controls transposon expression in animal germ cells, thereby ensuring genome stability over generations. In Drosophila, piRNAs are intergenerationally inherited through the maternal lineage, and this has demon
Externí odkaz:
https://doaj.org/article/7e7170d8f1084fafbe6be2d2ba3fdcc1
Autor:
Marzia Munafò, Victoria R Lawless, Alessandro Passera, Serena MacMillan, Susanne Bornelöv, Irmgard U Haussmann, Matthias Soller, Gregory J Hannon, Benjamin Czech
Publikováno v:
eLife, Vol 10 (2021)
The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 different nucleoporins (Nups), the NPC acts as a selective portal, interacting wit
Externí odkaz:
https://doaj.org/article/6b6faff476fb481f814cc489979dcd57
Autor:
Evelyn L Eastwood, Kayla A Jara, Susanne Bornelöv, Marzia Munafò, Vasileios Frantzis, Emma Kneuss, Elisar J Barbar, Benjamin Czech, Gregory J Hannon
Publikováno v:
eLife, Vol 10 (2021)
In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions. In Drosophila ovaries, piRNA-loaded Piwi detects nascent transposon transcripts and ins
Externí odkaz:
https://doaj.org/article/8c72a5d9b9b2465db0cee631acd9807f
Autor:
Nick K Jones, Lucy Rivett, Dominic Sparkes, Sally Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane Gray, Michael Gill, The CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R Bradley, Gregory J Hannon, Ian G Goodfellow, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Giles Wright, Nicholas J Matheson, Stephen Baker, Michael P Weekes
Publikováno v:
eLife, Vol 9 (2020)
Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-1
Externí odkaz:
https://doaj.org/article/23a09a039e26435589faa0bbe36f41e4
Autor:
Katherine G Zyner, Darcie S Mulhearn, Santosh Adhikari, Sergio Martínez Cuesta, Marco Di Antonio, Nicolas Erard, Gregory J Hannon, David Tannahill, Shankar Balasubramanian
Publikováno v:
eLife, Vol 8 (2019)
G-quadruplexes (G4) are alternative nucleic acid structures involved in transcription, translation and replication. Aberrant G4 formation and stabilisation is linked to genome instability and cancer. G4 ligand treatment disrupts key biological proces
Externí odkaz:
https://doaj.org/article/9345f52ec2454d159923cd9ac4bc1bbf
Autor:
Martin H Fabry, Filippo Ciabrelli, Marzia Munafò, Evelyn L Eastwood, Emma Kneuss, Ilaria Falciatori, Federica A Falconio, Gregory J Hannon, Benjamin Czech
Publikováno v:
eLife, Vol 8 (2019)
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptiona
Externí odkaz:
https://doaj.org/article/849bc140c7d04436961cec2abdc1d62a
Autor:
Olmo Sonzogni, Jennifer Haynes, Laurie A Seifried, Yahia M Kamel, Kai Huang, Michael D BeGora, Faith Au Yeung, Celine Robert-Tissot, Yujing J Heng, Xin Yuan, Gerbug M Wulf, Ken J Kron, Elvin Wagenblast, Mathieu Lupien, Thomas Kislinger, Gregory J Hannon, Senthil K Muthuswamy
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2004049 (2018)
The contribution of basal and luminal cells to cancer progression and metastasis is poorly understood. We report generation of reporter systems driven by either keratin-14 (K14) or keratin-8 (K8) promoter that not only express a fluorescent protein b
Externí odkaz:
https://doaj.org/article/5f14a8b0f9b94d6189d917aeaebfeb35
Autor:
M Joaquina Delás, Leah R Sabin, Egor Dolzhenko, Simon RV Knott, Ester Munera Maravilla, Benjamin T Jackson, Sophia A Wild, Tatjana Kovacevic, Eva Maria Stork, Meng Zhou, Nicolas Erard, Emily Lee, David R Kelley, Mareike Roth, Inês AM Barbosa, Johannes Zuber, John L Rinn, Andrew D Smith, Gregory J Hannon
Publikováno v:
eLife, Vol 6 (2017)
A substantial fraction of the genome is transcribed in a cell-type-specific manner, producing long non-coding RNAs (lncRNAs), rather than protein-coding transcripts. Here, we systematically characterize transcriptional dynamics during hematopoiesis a
Externí odkaz:
https://doaj.org/article/e9c2590fa9734ed099eb3c9e83222b6f