Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Gregory J Cost"'
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Akademický článek
Dissection of splicing regulation at an endogenous locus by zinc-finger nuclease-mediated gene editing.
Autor: Sandra Cristea, Philip D Gregory, Fyodor D Urnov, Gregory J Cost
Publikováno v: PLoS ONE, Vol 6, Iss 2, p e16961 (2011)
Sequences governing RNA splicing are difficult to study in situ due to the great difficulty of traditional targeted mutagenesis. Zinc-finger nuclease (ZFN) technology allows for the rapid and efficient introduction of site-specific mutations into mam
Externí odkaz: https://doaj.org/article/6fb9387b632942339d6e78b139477598
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4
Akademický článek
Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes
Autor: Daniela S. Aliaga Goltsman, Lisa M. Alexander, Jyun-Liang Lin, Rodrigo Fregoso Ocampo, Benjamin Freeman, Rebecca C. Lamothe, Andres Perez Rivas, Morayma M. Temoche-Diaz, Shailaja Chadha, Natalie Nordenfelt, Owen P. Janson, Ian Barr, Audra E. Devoto, Gregory J. Cost, Cristina N. Butterfield, Brian C. Thomas, Christopher T. Brown
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Programmable, RNA-guided nucleases are diverse enzymes that have been repurposed for biotechnological applications. Here, the authors mine an extensive genome-resolved metagenomics database and identified uncharacterized families of RNA-guided, compa
Externí odkaz: https://doaj.org/article/7663af1aa1e14736809578ccd16ebe1a
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7
Akademický článek
Directed assembly of DNA molecules via simultaneous ligation and digestion
Autor: Gregory J. Cost, Nicholas R. Cozzarelli
Publikováno v: BioTechniques, Vol 42, Iss 1, Pp 84-89 (2007)
DNA ligation is a routine laboratory practice, yet the yield of the desired product is often very low due to competing off-pathway reactions. The sensitivity of subsequent manipulations (e.g., selection via bacterial transformation) often obviates th
Externí odkaz: https://doaj.org/article/190c1e881ae8406cb5c3ca9d9d6ca82e
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8
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering for Cell Therapy Development
Autor: Cristina N. Butterfield, Meghan D. Storlie, Diego A. Espinosa, Brian C. Thomas, Gregory J. Cost, Andres Rivas, Rebecca C. Lamothe, Lisa Alexander, Daniela S. Aliaga Goltsman, Christopher T. Brown
Publikováno v: Blood. 138:3984-3984
Gene-editing technology has revolutionized molecular therapeutics, enabling DNA-engineering-based approaches to treat disease. Despite this, development of medicines using gene editing has been hampered by technological, immunological, and legal limi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54ca5756a66236211411cf4727c9fbb4
https://doi.org/10.1182/blood-2021-154407
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9
A Novel Type V CRISPR System with Potential for Genome Editing in the Liver
Autor: Janet Mei, Cristina N. Butterfield, Brooks Alan, Morayma Temoche-Diaz, Christopher T. Brown, Gregory J. Cost
Publikováno v: Blood. 138:1862-1862
RNA guided CRISPR genome editing systems can make specific changes to the genomes of mammalian cells and have the potential to treat a range of diseases including those that can be addressed by editing hepatocytes. Attempts to edit the liver in vivo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::864e3322f6695f3258310686e3b07ab2
https://doi.org/10.1182/blood-2021-154505
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