Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Gregory J, Morton"'
Autor:
Kendra L. Francis, Hengqi B. Zheng, David L. Suskind, Taylor A. Murphree, Bao Anh Phan, Emily Quah, Aarun S. Hendrickson, Xisheng Zhou, Mason Nuding, Alexandra S. Hudson, Miklos Guttman, Gregory J. Morton, Michael W. Schwartz, Kimberly M. Alonge, Jarrad M. Scarlett
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The intestinal extracellular matrix (ECM) helps maintain appropriate tissue barrier function and regulate host-microbial interactions. Chondroitin sulfate- and dermatan sulfate-glycosaminoglycans (CS/DS-GAGs) are integral components of the i
Externí odkaz:
https://doaj.org/article/079a8bfa3048479493c38f401f2d9cdd
Autor:
Jennifer D. Deem, David Tingley, Christina A. Watts, Kayoko Ogimoto, Caeley L. Bryan, Bao Anh N. Phan, Vincent Damian, Michael R. Bruchas, Jarrad M. Scarlett, Michael W. Schwartz, Gregory J. Morton
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101835- (2023)
Objective: Preserving core body temperature across a wide range of ambient temperatures requires adaptive changes of thermogenesis that must be offset by corresponding changes of energy intake if body fat stores are also to be preserved. Among neuron
Externí odkaz:
https://doaj.org/article/7556e099c97e49cabbcd44cff2dcf9cc
Autor:
Eunsang Hwang, Jarrad M. Scarlett, Arian F. Baquero, Camdin M. Bennett, Yanbin Dong, Dominic Chau, Jenny M. Brown, Aaron J. Mercer, Thomas H. Meek, Kevin L. Grove, Bao Anh N. Phan, Gregory J. Morton, Kevin W. Williams, Michael W. Schwartz
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
In rodent models of type 2 diabetes (T2D), central administration of FGF1 normalizes elevated blood glucose levels in a manner that is sustained for weeks or months. Increased activity of NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) is
Externí odkaz:
https://doaj.org/article/df6556bb07904915ad6da9a771a2e516
Autor:
Jenny M. Brown, Bao Anh Phan, Nadia Aalling, Gregory J. Morton, Michael W. Schwartz, Jarrad M. Scarlett
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101329- (2022)
Summary: Intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) elicits remission of diabetic hyperglycemia in rodent models of type 2 diabetes. Here, we present an optimized protocol to study the intracellular signaling pathway
Externí odkaz:
https://doaj.org/article/6b95298ae4dc47adb4a056ca6a63ba90
Autor:
Marie A. Bentsen, Dylan M. Rausch, Zaman Mirzadeh, Kenjiro Muta, Jarrad M. Scarlett, Jenny M. Brown, Vicente Herranz-Pérez, Arian F. Baquero, Jonatan Thompson, Kimberly M. Alonge, Chelsea L. Faber, Karl J. Kaiyala, Camdin Bennett, Charles Pyke, Cecilia Ratner, Kristoffer L. Egerod, Birgitte Holst, Thomas H. Meek, Burak Kutlu, Yu Zhang, Thomas Sparso, Kevin L. Grove, Gregory J. Morton, Birgitte R. Kornum, José-Manuel García-Verdugo, Anna Secher, Rasmus Jorgensen, Michael W. Schwartz, Tune H. Pers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
In rodent models of type 2 diabetes, sustained remission of hyperglycemia can be induced by FGF1 action in the mediobasal hypothalamus. Here, the authors show that FGF1-injection is followed by marked changes in glial cell populations and that the su
Externí odkaz:
https://doaj.org/article/3be801c6633040a49c4814f636359746
Autor:
Jenny M. Brown, Marie A. Bentsen, Dylan M. Rausch, Bao Anh Phan, Danielle Wieck, Huzaifa Wasanwala, Miles E. Matsen, Nikhil Acharya, Nicole E. Richardson, Xin Zhao, Peng Zhai, Anna Secher, Gregory J. Morton, Tune H. Pers, Michael W. Schwartz, Jarrad M. Scarlett
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102944- (2021)
Summary: The capacity of the brain to elicit sustained remission of hyperglycemia in rodent models of type 2 diabetes following intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) is well established. Here, we show that follo
Externí odkaz:
https://doaj.org/article/a1885c63ccdc425c86713ffd2aa00662
Autor:
Chelsea L Faber, Jennifer D Deem, Bao Anh Phan, Tammy P Doan, Kayoko Ogimoto, Zaman Mirzadeh, Michael W Schwartz, Gregory J Morton
Publikováno v:
eLife, Vol 10 (2021)
The brain plays an essential role in driving daily rhythms of behavior and metabolism in harmony with environmental light–dark cycles. Within the brain, the dorsomedial hypothalamic nucleus (DMH) has been implicated in the integrative circadian con
Externí odkaz:
https://doaj.org/article/de654672db84412caa24254afde95e76
Autor:
Jennifer D Deem, Chelsea L Faber, Christian Pedersen, Bao Anh Phan, Sarah A Larsen, Kayoko Ogimoto, Jarrell T Nelson, Vincent Damian, Megan A Tran, Richard D Palmiter, Karl J Kaiyala, Jarrad M Scarlett, Michael R Bruchas, Michael W Schwartz, Gregory J Morton
Publikováno v:
eLife, Vol 9 (2020)
To maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake. To investigate the neurobiological mechanisms underlying this cold-induced hyperphagia, we asked wh
Externí odkaz:
https://doaj.org/article/3bf1e03edc9c473196f7e1c90cbf2a36
Autor:
Katya B Rubinow, Barbara Houston, Shari Wang, Leela Goodspeed, Kayoko Ogimoto, Gregory J Morton, Christopher McCarty, Robert E Braun, Stephanie T Page
Publikováno v:
Asian Journal of Andrology, Vol 20, Iss 3, Pp 276-283 (2018)
Androgen deprivation in men leads to increased adiposity, but the mechanisms underlying androgen regulation of fat mass have not been fully defined. Androgen receptor (AR) is expressed in monocytes/macrophages, which are resident in key metabolic tis
Externí odkaz:
https://doaj.org/article/9a1337f7c38f4243a0f5b086461988fb
Autor:
Mauricio D. Dorfman, Jordan E. Krull, John D. Douglass, Rachael Fasnacht, Fernando Lara-Lince, Thomas H. Meek, Xiaogang Shi, Vincent Damian, Hong T. Nguyen, Miles E. Matsen, Gregory J. Morton, Joshua P. Thaler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mec
Externí odkaz:
https://doaj.org/article/c3d9bcc58c004e1b9f6eb255e257f3c4