Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gregory J, Brunn"'
Autor:
Jeffrey L. Platt, Gregory J. Brunn
Publikováno v:
Reviews in Cell Biology and Molecular Medicine
For nearly a century, xenotransplantation has been seen as a potential curative approach to replacing the function of diseased or damaged organs. Until recently, however, the application of xenotransplantation has seemed only a remote possibility. Ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0887137009efa8b9eb61034195cf095
https://doi.org/10.1002/9783527632909.ch22
https://doi.org/10.1002/9783527632909.ch22
Autor:
Jeffrey L. Platt, Justin E. Juskewitch, Gregory J. Brunn, Bruce E. Knudsen, Joseph P. Grande, Karl A. Nath, Keith L. Knutson
Publikováno v:
The American Journal of Pathology. 180:32-40
Systemic inflammation remains a major cause of morbidity and mortality in the United States, across many disease processes. One classic murine model to study this syndrome is lipopolysaccharide (LPS)–induced Toll-like receptor 4 (TLR4)–dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a13abdeb7d9d9b4d171f6dd1d2d364
https://doi.org/10.1016/j.ajpath.2011.10.001
https://doi.org/10.1016/j.ajpath.2011.10.001
Publikováno v:
Thrombosis Research. 126:414-417
Effects of in vivo stimulation of toll-like receptor 4 (TLR4) with LPS were evaluated on murine platelets. A single intravenous LPS injection, in amounts below those stimulating increases in serum TNFα, induced platelet activation and increased plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3e334f1dee6067bd1f14893eb3dcb8
https://doi.org/10.1016/j.thromres.2009.05.005
https://doi.org/10.1016/j.thromres.2009.05.005
Autor:
Alan R. Zinsmeister, Adil E. Bharucha, Simon J. Gibbons, Kyoung Moo Choi, Michael Camilleri, Gianrico Farrugia, Anuja Kulkarni, Gregory J. Brunn, Mary Lempke
Publikováno v:
Clinical Pharmacology & Therapeutics. 87:187-190
Heme oxygenase (HO)-1 degrades heme and protects against oxidative stress, but it has not been pharmacologically induced in humans. In this randomized study of 10 healthy volunteers, hemin (3 mg/kg intravenously in 25% albumin) was shown to increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e635c68665cad1b532ef61a315743fe
https://doi.org/10.1038/clpt.2009.221
https://doi.org/10.1038/clpt.2009.221
Publikováno v:
Circulation Research. 102:823-830
Activation of complement stimulates inflammation and provides an initial vigorous defense against infection. Insertion of the membrane attack complex in cell membranes of vascular endothelial cells induces changes in cell differentiation that promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b17f44ea6dbdc9cd6c9f06f8e1df9ef
https://doi.org/10.1161/circresaha.107.165332
https://doi.org/10.1161/circresaha.107.165332
Autor:
Krzysztof Karnicki, Gregory J. Brunn, Randall S. Miller, Whyte G. Owen, Virginia M. Miller, Muthuvel Jayachandran
Publikováno v:
Journal of Applied Physiology. 102:429-433
Gram-negative bacteria release LPS, which activates Toll-like-receptor-4 (TLR4) in the host, initiating an inflammatory response to infection. Infection increases risk for thrombosis. Platelets contribute to defense from infection and to thrombosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c501dc099adb5469b68e2abfece7a44c
https://doi.org/10.1152/japplphysiol.01576.2005
https://doi.org/10.1152/japplphysiol.01576.2005
Autor:
Jeffrey L. Platt, Xiulong Xu, Gregory J. Brunn, Anthony W. Kim, Paolo Gattuso, Hua Quan Miao, Richard A. Prinz, Geetha Rao, Roderick M. Quiros
Publikováno v:
Journal of Biological Chemistry. 282:2363-2373
Heparan sulfate proteoglycans (HSPGs) function as a co-receptor for heparin-binding growth factors, such as fibroblast growth factors (FGFs) and heparin-bound epidermal growth factor (HB-EGF). The HS side chain of HSPGs can be cleaved by HPR1 (hepara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34a47e604af8ade50fd6713b693eb883
https://doi.org/10.1074/jbc.m604218200
https://doi.org/10.1074/jbc.m604218200
Publikováno v:
Circulation Research. 98:793-800
Activation of complement on endothelium triggers physiological changes that promote coagulation, thrombosis, and inflammation. Unlike agonists such as cytokines and endotoxin that induce these changes through transcription of many genes, complement,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f826c6d3396b300d36e3e402f74e168
https://doi.org/10.1161/01.res.0000216071.87981.16
https://doi.org/10.1161/01.res.0000216071.87981.16
Autor:
Gregory J. Brunn, Shu S. Lin, Zoie E. Holzknecht, Josie M. Williams, Timothy B. Plummer, Jeffrey L. Platt
Publikováno v:
Transplantation. 78:1471-1478
Background. The most difficult barrier to organ transplantation is humoral rejection, a condition initiated by binding of antibodies to blood vessels in the graft. Fortunately, humoral rejection is not the only outcome of antibody binding to the graf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb26eceaa3de8d4f8dadcd8d05e75821
https://doi.org/10.1097/01.tp.0000140770.81537.64
https://doi.org/10.1097/01.tp.0000140770.81537.64
Publikováno v:
The Journal of Immunology. 172:20-24
Systemic inflammatory response syndrome (SIRS) is typically associated with trauma, surgery, or acute pancreatitis. SIRS resembles sepsis, triggered by exogenous macromolecules such as LPS acting on Toll-like receptors. What triggers SIRS in the abse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79394c4d89cd106981def13184aeb68
https://doi.org/10.4049/jimmunol.172.1.20
https://doi.org/10.4049/jimmunol.172.1.20