Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gregory J, Brunette"'
Autor:
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise is poorly understood. Here we perform haplotype-specific analysis of chromosomal c
Externí odkaz:
https://doaj.org/article/283f7ed4b40c43818c5d64ef72721c07
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-31 (2021)
Abstract Haplotype phase represents the collective genetic variation between homologous chromosomes and is an essential feature of non-haploid genomes. Here we describe a computational strategy to reliably determine complete whole-chromosome haplotyp
Externí odkaz:
https://doaj.org/article/0bb7695dfc864bdfb41f9ce3ac504c23
Autor:
Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Homologous recombination (HR) is an essential DNA repair pathway for genomic stability. Here the authors show that C17orf53/MCM8IP, an OB-fold containing protein, promotes HR through direct binding and activation of the MCM8-9 helicase complex.
Externí odkaz:
https://doaj.org/article/86fa91a9e36c4bd1bfde918a8bfb93ee
Autor:
Edwige B Garcin, Stéphanie Gon, Meghan R Sullivan, Gregory J Brunette, Anne De Cian, Jean-Paul Concordet, Carine Giovannangeli, Wilhelm G Dirks, Sonja Eberth, Kara A Bernstein, Rohit Prakash, Maria Jasin, Mauro Modesti
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008355 (2019)
Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were generated in
Externí odkaz:
https://doaj.org/article/edf562de560749c6ba7db2b329674714
Autor:
Clare L. Scott, Kevin K. Lin, Elizabeth M. Swisher, Iain A. McNeish, Mitch Raponi, Thomas C. Harding, Andrew D. Simmons, Scott H. Kaufmann, Matthew J. Wakefield, Heidi Giordano, David Bowtell, Lara Maloney, Liliane Robillard, James Sun, Amit Oza, David M. O'Malley, Ganessan Kichenadasse, Michael Friedlander, Anne Floquet, Robert L. Coleman, Kara A. Bernstein, Gregory J. Brunette, Meghan R. Sullivan, Elizabeth M. Kass, Rohit Prakash, Maria Jasin, Holly Barker, Gwo-Yaw Ho, Michael J. Kuiper, Maria I. Harrell, Nelson N.H. Teng, Anna V. Tinker, Kristy Shield-Artin, Minh Nguyen, Olga Kondrashova
A list of copy number alterations, rearrangements and short variants detected by Foundation Medicine NGS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290d4db2a909f21e74c4707ffaf15b8c
https://doi.org/10.1158/2159-8290.22532014
https://doi.org/10.1158/2159-8290.22532014
Autor:
Clare L. Scott, Kevin K. Lin, Elizabeth M. Swisher, Iain A. McNeish, Mitch Raponi, Thomas C. Harding, Andrew D. Simmons, Scott H. Kaufmann, Matthew J. Wakefield, Heidi Giordano, David Bowtell, Lara Maloney, Liliane Robillard, James Sun, Amit Oza, David M. O'Malley, Ganessan Kichenadasse, Michael Friedlander, Anne Floquet, Robert L. Coleman, Kara A. Bernstein, Gregory J. Brunette, Meghan R. Sullivan, Elizabeth M. Kass, Rohit Prakash, Maria Jasin, Holly Barker, Gwo-Yaw Ho, Michael J. Kuiper, Maria I. Harrell, Nelson N.H. Teng, Anna V. Tinker, Kristy Shield-Artin, Minh Nguyen, Olga Kondrashova
Supplementary Tables, Figures and Video legends, Tables 2,3,5 and all Supplementary Figures. Supplementary Table 2. Confirmation of cis configuration of BRCA1 primary and secondary mutations in case 4 by colony PCR. Supplementary Table 3. IC50 (mirco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397e20de6afaeebadb9878c50aa24cdb
https://doi.org/10.1158/2159-8290.22532005
https://doi.org/10.1158/2159-8290.22532005
Autor:
Clare L. Scott, Kevin K. Lin, Elizabeth M. Swisher, Iain A. McNeish, Mitch Raponi, Thomas C. Harding, Andrew D. Simmons, Scott H. Kaufmann, Matthew J. Wakefield, Heidi Giordano, David Bowtell, Lara Maloney, Liliane Robillard, James Sun, Amit Oza, David M. O'Malley, Ganessan Kichenadasse, Michael Friedlander, Anne Floquet, Robert L. Coleman, Kara A. Bernstein, Gregory J. Brunette, Meghan R. Sullivan, Elizabeth M. Kass, Rohit Prakash, Maria Jasin, Holly Barker, Gwo-Yaw Ho, Michael J. Kuiper, Maria I. Harrell, Nelson N.H. Teng, Anna V. Tinker, Kristy Shield-Artin, Minh Nguyen, Olga Kondrashova
Molecular Dynamics Modeling of WT RAD51D monofilament interaction with dsDNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fba9c22b5a359aa72c1e801f4e7723
https://doi.org/10.1158/2159-8290.22532008
https://doi.org/10.1158/2159-8290.22532008
Autor:
Clare L. Scott, Kevin K. Lin, Elizabeth M. Swisher, Iain A. McNeish, Mitch Raponi, Thomas C. Harding, Andrew D. Simmons, Scott H. Kaufmann, Matthew J. Wakefield, Heidi Giordano, David Bowtell, Lara Maloney, Liliane Robillard, James Sun, Amit Oza, David M. O'Malley, Ganessan Kichenadasse, Michael Friedlander, Anne Floquet, Robert L. Coleman, Kara A. Bernstein, Gregory J. Brunette, Meghan R. Sullivan, Elizabeth M. Kass, Rohit Prakash, Maria Jasin, Holly Barker, Gwo-Yaw Ho, Michael J. Kuiper, Maria I. Harrell, Nelson N.H. Teng, Anna V. Tinker, Kristy Shield-Artin, Minh Nguyen, Olga Kondrashova
Copy number estimation by SNP array in the archival tumor tissue of the patient identified to have a germline RAD51C mutation (c.577C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916a972cc1b288a8152b36cc181d3f6a
https://doi.org/10.1158/2159-8290.22532011.v1
https://doi.org/10.1158/2159-8290.22532011.v1
Publikováno v:
Cancer Research. 83:6105-6105
Genome evolution can happen gradually or via bursts of rearrangements. Chromoplexy is an example of a process driving rapid genome evolution. This mutational signature is detected in ~18% of human cancers (PCAWG Consortium, 2020) and is frequently ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::770cfe9ccf55c6830c93cff365b77010
https://doi.org/10.1158/1538-7445.am2023-6105
https://doi.org/10.1158/1538-7445.am2023-6105
Autor:
Jon M. Davison, Masayuki Watanabe, Robert D. Odze, Gad Getz, Chip Stewart, Katie S. Nason, Hideo Baba, Casey H Zhang, Kunal Jajoo, Lili Sun, Chunyang Bao, Gregory J. Brunette, Richard W. Tourdot, Kenneth K. Wang, Agoston T. Agoston, Yu Imamura, Adam J. Bass, Stachler M
Complex chromosomal alterations are a hallmark of advanced cancers but rarely seen in normal tissue. The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations that can drive their t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e016684819e34fc022ab8ed34dfac207
https://doi.org/10.1101/2021.03.26.437288
https://doi.org/10.1101/2021.03.26.437288