Výsledky vyhledávání - "Gregory I. Liou"

Olive and ginkgo extracts as potential cataract therapy with differential inhibitory activity on aldose reductase

Autor: Ahmed Ibrahim, Diaaeldin Mohamed Abdelkawi Elimam, Gregory I. Liou, Farid Abd Elrehim Abd Elaziz Badria

Publikováno v: Drug Discoveries & Therapeutics. 11:41-46

Aldose reductase (AR) has been the leading target in the treatment of diabetic cataract. Although numerous synthetic AR inhibitors (ARI) have been identified, their adverse side effects currently preclude their use. Olive leaf extract (OLE) as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70da70b4141c01a02cae3371157c997
https://doi.org/10.5582/ddt.2016.01071

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Adenosine Deaminase-2-Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p

Autor: Laila A. Eissa, Khaled Elmasry, Sadanand Fulzele, Yara A. Samra, Heba Saleh, Nehal M. Elsherbiny, Gregory I. Liou, Ahmed Ibrahim, Khaled A. Hussein, Mamdouh M. El-Shishtawy, Mohamed Al-Shabrawey

Publikováno v: Investigative Ophthalmology & Visual Science

Purpose We recently demonstrated that adenosine deaminase-2 (ADA2) contributes to diabetic retinopathy (DR) via up-regulating the production of inflammatory cytokines in macrophages. Also, microRNA (miR)-146b-3p has the ability to inhibit ADA2. The g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa8371c9dfa813100ce77ac7412a56e
https://pubmed.ncbi.nlm.nih.gov/28170537

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Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy

Autor: Gregory I. Liou, Nehal M. Elsherbiny, Saif Ahmad, Kanchan Bhatia, Ahmed Elsherbini, Sadanand Fulzele

Publikováno v: Journal of Neuroimmunology. 277:96-104

Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075a41af8cc1e2a5fcc02d5c864f1016
https://doi.org/10.1016/j.jneuroim.2014.10.006

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Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms

Autor: Ahmed Ibrahim, Nehal M. Elsherbiny, Ahmed Chadli, Chelsey Pye, Mohamed Al-Shabrawey, Gregory I. Liou, Ahmed A. Elmarakby

Publikováno v: Pharmacological Research. 85:45-54

Adenosine provides anti-inflammatory effects in cardiovascular disease via the activation of adenosine A2A receptors; however, the physiological effect of adenosine could be limited due to its phosphorylation by adenosine kinase. We hypothesized that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f86c61b3c2a2e9dacd45cdeb2dc2602
https://doi.org/10.1016/j.phrs.2014.05.004

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Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome

Autor: Laila A. Eissa, Mamdouh M. El-Shishtawy, Nehal M. Elsherbiny, Heba S. Said, Yara A. Samra, Gregory I. Liou

Publikováno v: Life sciences. 157

Aims Hyperglycemia leads to elevation of oxidative stress and proinflammatory cytokines which are the main causes of diabetic nephropathy (DN). NLRP3 inflammasome and thioredoxin-interacting protein (TXNIP) are recently assumed to participate in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474e26f8ab1b79ebbd255af634a945dc
https://pubmed.ncbi.nlm.nih.gov/27266851

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Loss of thioredoxin function in retinas of mice overexpressing amyloid β

Autor: Gregory I. Liou, Pamela M. Martin, Manuela Bartoli, Annalisa Montemari, AnnaMaria Maraschi, Dennis M. Marcus, Scott J. Webster, Folami Lamoke, Guido Ripandelli

Publikováno v: Free Radical Biology and Medicine. 53:577-588

Amyloid β peptides (Aβ) have been implicated in the pathogenesis of age-related macular degeneration (ARMD) and glaucoma. In this study, retinas of mice overexpressing Aβ (Tg) were compared to those of wild-type mice (Wt) and analyzed for oxidativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf37ebca7343fd235b176d1dab875c0
https://doi.org/10.1016/j.freeradbiomed.2012.04.010

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Tyrosine kinase inhibitor, genistein, reduces renal inflammation and injury in streptozotocin-induced diabetic mice

Autor: Ahmed Ibrahim, Ahmed A. Elmarakby, Jessica L. Faulkner, Gregory I. Liou, Rafik A. Abdelsayed, Mahmood S. Mozaffari

Publikováno v: Vascular Pharmacology. 55:149-156

Tyrosine kinase inhibition is known to reduce diabetes-induced end-organ damage but the mechanisms remain elusive. We hypothesized that inhibition of tyrosine kinase reduces renal inflammation and injury in streptozotocin-induced diabetes. Male C57BL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5febd125db1e7e8684c159af87a357aa
https://doi.org/10.1016/j.vph.2011.07.007

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A2A Adenosine Receptor (A2AAR) as a Therapeutic Target in Diabetic Retinopathy

Autor: Gregory I. Liou, Mamdouh M. El-Shishtawy, Wenbo Zhang, Ahmed Ibrahim, Ruth B. Caldwell

Publikováno v: The American Journal of Pathology. 178:2136-2145

In diabetic retinopathy (DR), abnormalities in vascular and neuronal function are closely related to the local production of inflammatory mediators whose potential source is microglia. A2A adenosine receptor (A2AAR) has been shown to possess anti-inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b899bb33095c3193a224402624bdf1de
https://doi.org/10.1016/j.ajpath.2011.01.018

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