Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gregory I Lang"'
Autor:
Ryan C Vignogna, Mariateresa Allocca, Maria Monticelli, Joy W Norris, Richard Steet, Ethan O Perlstein, Giuseppina Andreotti, Gregory I Lang
Publikováno v:
eLife, Vol 11 (2022)
The most common cause of human congenital disorders of glycosylation (CDG) are mutations in the phosphomannomutase gene PMM2, which affect protein N-linked glycosylation. The yeast gene SEC53 encodes a homolog of human PMM2. We evolved 384 population
Externí odkaz:
https://doaj.org/article/12fb21d1e1c5435787fcfc54b0ca4d30
Publikováno v:
eLife, Vol 9 (2020)
A common misconception is that evolution is a linear ‘march of progress’, where each organism along a line of descent is more fit than all those that came before it. Rejecting this misconception implies that evolution is nontransitive: a series o
Externí odkaz:
https://doaj.org/article/231e1094c5794ea89684a33589296ca5
Autor:
Giltae Song, Jongin Lee, Juyeon Kim, Seokwoo Kang, Hoyong Lee, Daehong Kwon, Daehwan Lee, Gregory I Lang, J Michael Cherry, Jaebum Kim
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221858 (2019)
BackgroundGenomic data have become major resources to understand complex mechanisms at fine-scale temporal and spatial resolution in functional and evolutionary genetic studies, including human diseases, such as cancers. Recently, a large number of w
Externí odkaz:
https://doaj.org/article/4596729c286a4206bf74a5111eef5249
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007396 (2018)
Genome duplications are important evolutionary events that impact the rate and spectrum of beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments initiated with haploid Saccharomyces cerevisiae cultures repeatedly expe
Externí odkaz:
https://doaj.org/article/5773a4fe706b4e3bade310f5a18755df
Autor:
Gregory I Lang, David Botstein
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25290 (2011)
Metabolic gene clusters--functionally related and physically clustered genes--are a common feature of some eukaryotic genomes. Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expres
Externí odkaz:
https://doaj.org/article/d7d9db45a4e647a5b3bbf241abaef9e3
Publikováno v:
Journal of Molecular Evolution. 91:46-59
Galactose is a secondary fermentable sugar that requires specific regulatory and structural genes for its assimilation, which are under catabolite repression by glucose. When glucose is absent, the catabolic repression is attenuated, and the structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9844adb881399744b13b923339abb57
https://doi.org/10.1007/s00239-022-10079-9
https://doi.org/10.1007/s00239-022-10079-9
Publikováno v:
Journal of Molecular Evolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8968125855e4a3fa66b41565d76f6b08
https://doi.org/10.1007/s00239-023-10119-y
https://doi.org/10.1007/s00239-023-10119-y
Autor:
Artemiza A. Martínez, Gregory I. Lang
Publikováno v:
Journal of Molecular Evolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa942b4f72a6a273c32e21dc5fbc25fe
https://doi.org/10.1007/s00239-023-10096-2
https://doi.org/10.1007/s00239-023-10096-2
Autor:
Ryan C Vignogna, Mariateresa Allocca, Maria Monticelli, Joy W Norris, Richard Steet, Ethan O Perlstein, Giuseppina Andreotti, Gregory I Lang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac52390f0bd8a4f9c6859686e6c26700
https://doi.org/10.7554/elife.79346.sa2
https://doi.org/10.7554/elife.79346.sa2
Publikováno v:
Molecular Biology and Evolution
Understanding how genes interact is a central challenge in biology. Experimental evolution provides a useful, but underutilized, tool for identifying genetic interactions, particularly those that involve non-loss-of-function mutations or mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdb2ed6d2f6ff0b353b3678142811c1
https://doi.org/10.1093/molbev/msab087
https://doi.org/10.1093/molbev/msab087