Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Gregory I Frolenkov"'
Autor:
A Catalina Vélez-Ortega, Mary J Freeman, Artur A Indzhykulian, Jonathan M Grossheim, Gregory I Frolenkov
Publikováno v:
eLife, Vol 6 (2017)
Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influ
Externí odkaz:
https://doaj.org/article/6b40637b5dc84d4c8a686f5c61ecafd7
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionMammalian hearing depends on the dual mechanosensory and motor functions of cochlear hair cells. Both these functions may be regulated by Ca2+ release from intracellular stores. However, it is still unclear how exactly intracellular Ca2+
Externí odkaz:
https://doaj.org/article/73bf3074fe8544d9a35cba24c4520ca4
Autor:
Qing Fang, Artur A Indzhykulian, Mirna Mustapha, Gavin P Riordan, David F Dolan, Thomas B Friedman, Inna A Belyantseva, Gregory I Frolenkov, Sally A Camper, Jonathan E Bird
Publikováno v:
eLife, Vol 4 (2015)
The precise assembly of inner ear hair cell stereocilia into rows of increasing height is critical for mechanotransduction and the sense of hearing. Yet, how the lengths of actin-based stereocilia are regulated remains poorly understood. Mutations of
Externí odkaz:
https://doaj.org/article/2bb78c086df8425aa92d18252eff5938
Autor:
Kunjan Patel, Arnaud P Giese, J M Grossheim, Rashmi S Hegde, Maria Delio, Joy Samanich, Saima Riazuddin, Gregory I Frolenkov, Jinlu Cai, Zubair M Ahmed, Bernice E Morrow
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141259 (2015)
Externí odkaz:
https://doaj.org/article/30a149114bd04a568cf6c7798c792084
Autor:
Kunjan Patel, Arnaud P Giese, J M Grossheim, Rashmi S Hegde, Maria Delio, Joy Samanich, Saima Riazuddin, Gregory I Frolenkov, Jinlu Cai, Zubair M Ahmed, Bernice E Morrow
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0133082 (2015)
Hearing loss is a complex disorder caused by both genetic and environmental factors. Previously, mutations in CIB2 have been identified as a common cause of genetic hearing loss in Pakistani and Turkish populations. Here we report a novel (c.556C>T;
Externí odkaz:
https://doaj.org/article/7c25e98ab1604238ab40b31e9ec90e09
Autor:
Artur A Indzhykulian, Ruben Stepanyan, Anastasiia Nelina, Kateri J Spinelli, Zubair M Ahmed, Inna A Belyantseva, Thomas B Friedman, Peter G Barr-Gillespie, Gregory I Frolenkov
Publikováno v:
PLoS Biology, Vol 11, Iss 6, p e1001583 (2013)
Sound detection by inner ear hair cells requires tip links that interconnect mechanosensory stereocilia and convey force to yet unidentified transduction channels. Current models postulate a static composition of the tip link, with protocadherin 15 (
Externí odkaz:
https://doaj.org/article/dce20030d1bd4f91a84ae8fa5707710a
Autor:
A. Catalina Vélez-Ortega, Ruben Stepanyan, Stephanie E. Edelmann, Sara Torres-Gallego, Channy Park, Desislava A. Marinkova, Joshua S. Nowacki, Ghanshyam P. Sinha, Gregory I. Frolenkov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract TRPA1 channels are expressed in nociceptive neurons, where they detect noxious stimuli, and in the mammalian cochlea, where their function is unknown. Here we show that TRPA1 activation in the supporting non-sensory Hensen’s cells of the m
Externí odkaz:
https://doaj.org/article/ec225dd281ae4471b26329b0f9f9f560
Autor:
Farah El Najjar, Santiago Restrepo Castillo, Carole L. Moncman, Cheng-Yu Wu, Eduardo Isla, A. Catalina Velez Ortega, Gregory I. Frolenkov, Nicolas Cifuentes-Munoz, Rebecca Ellis Dutch
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Human metapneumovirus (HMPV) can spread between cells through budding of virus particles or direct cell-to-cell spread. A network of budding filaments and intercellular extensions forms in HMPV-infected cells; however, the involvement of the
Externí odkaz:
https://doaj.org/article/aeeb68ebc62e425fa76027360b5d648c
Autor:
A. Catalina Vélez-Ortega, Ruben Stepanyan, Stephanie E. Edelmann, Sara Torres-Gallego, Channy Park, Desislava A. Marinkova, Joshua S. Nowacki, Ghanshyam P. Sinha, Gregory I. Frolenkov
TRPA1 channels are expressed in nociceptive neurons, where they detect noxious stimuli, and in the mammalian cochlea, where their function is unknown. Here we show that TRPA1 activation in the supporting non-sensory Hensen’s cells causes prolonged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5b1565b476bdd04879154bc1e34bd1
https://doi.org/10.1101/2022.10.30.514409
https://doi.org/10.1101/2022.10.30.514409
Autor:
Jeffrey S. Rush, Nina M. van Sorge, Andrew B. Herr, Sowmya Ajay Castro, Natalia Korotkova, Svetlana Zamakhaeva, Cameron W. Kenner, Gregory I. Frolenkov, Alexander E. Yarawsky, Konstantin V. Korotkov, Helge C. Dorfmueller, Catherine T. Chaton
Publikováno v:
Nat Chem Biol
Nature chemical biology, 17(8), 878-887. Nature Publishing Group
Nature chemical biology, 17(8), 878-887. Nature Publishing Group
In ovoid-shaped, Gram-positive bacteria, MapZ guides FtsZ-ring positioning at cell equators. The cell wall of the ovococcus Streptococcus mutans contains peptidoglycan decorated with serotype c carbohydrates (SCCs). In the present study, we identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8eb92634c21ad0655c71f95b7dfd120
https://doi.org/10.1038/s41589-021-00803-9
https://doi.org/10.1038/s41589-021-00803-9