Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Gregory Hook"'
Publikováno v:
J Alzheimers Dis
The lysosomal cysteine protease cathepsin B (CTSB) has been suggested as a biomarker for Alzheimer’s disease (AD) because elevated serum CTSB in AD patients has been found to correlate with cognitive dysfunction. Furthermore, CTSB gene knockout (KO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615650dd4bf051a5365488e69fc3a8d6
https://europepmc.org/articles/PMC10185432/
https://europepmc.org/articles/PMC10185432/
Autor:
Anthony J. O’Donoghue, William H. Gerwick, Dennis W. Wolan, Michael C Yoon, Angelo Solania, Gregory Hook, Zhenze Jiang, Sonia Podvin, Christopher B. Lietz, Mitchell P. Christy, Vivian Hook, Charles Mosier, Gen Ito
Publikováno v:
ACS Chemical Biology. 16:1628-1643
Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin B translocates to the cytosol having neutral pH where the enzyme activates inflammation and cell dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398c823ce5d9657c488f430417ed8685
https://doi.org/10.1021/acschembio.1c00138
https://doi.org/10.1021/acschembio.1c00138
Publikováno v:
npj Climate Action, Vol 3, Iss 1, Pp 1-11 (2024)
Abstract Our case-oriented analysis of the drivers of climate change highlights the barriers and pathways to climate action. We employ Qualitative Comparative Analysis (QCA), specifically fuzzy set Qualitative Comparative Analysis (fsQCA), to trace t
Externí odkaz:
https://doaj.org/article/b39f02ba19d4449e8331711e150371a6
Autor:
Janice S. Gilsdorf, Zhihui Yang, Bharani Thangavelu, Claudia S. Robertson, Deborah A. Shear, Kevin K.W. Wang, George Anis Sarkis, Vivian Hook, Brittany N Abbatiello, Gregory Hook, J. Steven Jacobsen, Angela M. Boutté
Publikováno v:
J Neurotrauma
Cathepsin B (CatB), a lysosomal cysteine protease, is important to brain function and may have dual utility as a peripheral biomarker of moderate-severe traumatic brain injury (TBI). The present study determined levels of pro- and mature (mat) CatB p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf77cc3204b7340077de96ab274b4a6
https://doi.org/10.1089/neu.2019.6537
https://doi.org/10.1089/neu.2019.6537
Publikováno v:
J Neurochem
Lysosomes are known to mediate neurite outgrowth in neurons. However, the principal lysosomal molecule controlling that outgrowth is unclear. We studied primary mouse neurons in vitro and found that they naturally develop neurite outgrowths over time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5b8394fe86ebc4c88c5cb26e638735
https://doi.org/10.1111/jnc.15032
https://doi.org/10.1111/jnc.15032
Autor:
Michael C. Yoon, Mitchell P. Christy, Von V. Phan, William H. Gerwick, Gregory Hook, Anthony J. O’Donoghue, Vivian Hook
Publikováno v:
Biochemistry, vol 61, iss 4
Biochemistry
Biochemistry
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. CA-074 has been utilized in numerous studies to demonstrate the role of this protease in cellular and physiological functions. Cathepsin B in numerous human disease mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b70cd637f396d21a3714de260fe39f9
https://escholarship.org/uc/item/0rv2s1b3
https://escholarship.org/uc/item/0rv2s1b3
Autor:
Charles Mosier, Brian P. Head, Anthony J. O’Donoghue, Gregory Hook, Vivian Hook, Gen Ito, Robert A. Rissman, Sonia Podvin, Michael Yoon
Publikováno v:
Biochim Biophys Acta Proteins Proteom
Investigations of Alzheimer’s disease (AD), traumatic brain injury (TBI), and related brain disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal cysteine protease, in mediating the behavioral deficits and neuropath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59122f1f17417237332fcfff8bd9db8f
https://doi.org/10.1016/j.bbapap.2020.140428
https://doi.org/10.1016/j.bbapap.2020.140428
Publikováno v:
Journal of Alzheimer's Disease. 41:129-149
Pyroglutamate amyloid-β peptides (pGlu-Aβ) are particularly pernicious forms of amyloid-β peptides (Aβ) present in Alzheimer’s disease (AD) brains. pGlu-Aβ peptides are N-terminally truncated forms of full-length Aβ peptides (flAβ(1-40/42))
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2236192f5b056f2c30b6a6773032efe0
https://doi.org/10.3233/jad-131370
https://doi.org/10.3233/jad-131370
Publikováno v:
Journal of Neurotrauma. 31:515-529
There are currently no effective therapeutic agents for traumatic brain injury (TBI), but drug treatments for TBI can be developed by validation of new drug targets and demonstration that compounds directed to such targets are efficacious in TBI anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a359edecdfef7d63069dbeefc0bc2b
https://doi.org/10.1089/neu.2013.2944
https://doi.org/10.1089/neu.2013.2944
Publikováno v:
Biochemical and Biophysical Research Communications; Vol 386
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications
Neurotoxic beta-amyloid (Abeta) peptides participate in Alzheimer's disease (AD); therefore, reduction of Abeta generated from APP may provide a therapeutic approach for AD. Gene knockout studies in transgenic mice producing human Abeta may identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe60edaeb916af5871e13eae8928ea3
https://doi.org/10.1016/j.bbrc.2009.05.131
https://doi.org/10.1016/j.bbrc.2009.05.131