Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gregory H. Babunovic"'
Autor:
Joanne M. O’Hara, Shoko Wakabayashi, Noman Siddiqi, Elaine Cheung, Gregory H. Babunovic, Claudette M. Thompson, Ying-Jie Lu, Eric J. Rubin, Richard Malley, Fan Zhang
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. To date, the mainstay of vaccination involves the use of Mycobacterium bovis bacillus Calmette-Guérin (BCG), a live-attenuated vaccine that confers protection a
Externí odkaz:
https://doaj.org/article/15433358462e4d84870b86d92f699477
Autor:
Gregory H. Babunovic, Michael A. DeJesus, Barbara Bosch, Michael R. Chase, Thibault Barbier, Amy K. Dickey, Bryan D. Bryson, Jeremy M. Rock, Sarah M. Fortune
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Macrophages are a protective replicative niche for Mycobacterium tuberculosis (Mtb) but can kill the infecting bacterium when appropriately activated. To identify mechanisms of clearance, we compared levels of bacterial restriction by human
Externí odkaz:
https://doaj.org/article/92eb1a5d9c3648df89b29579cd8c4859
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Shigellosis causes most diarrheal deaths worldwide, particularly affecting children. Shigella invades and replicates in the epithelium of the large intestine, eliciting inflammation and tissue destruction. To understand how Shigella rewires
Externí odkaz:
https://doaj.org/article/15e9da1bb1a442e4a77457edf8c65820
Autor:
Bryan D. Bryson, Tracy R. Rosebrock, Fikadu G. Tafesse, Christopher Y. Itoh, Armel Nibasumba, Gregory H. Babunovic, Bjorn Corleis, Constance Martin, Caroline Keegan, Priscila Andrade, Susan Realegeno, Douglas Kwon, Robert L. Modlin, Sarah M. Fortune
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, r
Externí odkaz:
https://doaj.org/article/7b1cd08cca8c4de48969bd62ffdea2d7
Autor:
Qingyun Liu, Junhao Zhu, Charles L. Dulberger, Sydney Stanley, Sean Wilson, Eun Seon Chung, Xin Wang, Peter Culviner, Yue J. Liu, Nathan D. Hicks, Gregory H. Babunovic, Samantha R. Giffen, Bree B. Aldridge, Ethan C. Garner, Eric J. Rubin, Michael C. Chao, Sarah M. Fortune
Publikováno v:
Science
The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis ( Mtb ) clinical isolates has identified an essential transcriptional reg
Autor:
Alex K. Shalek, Armel Nibasumba, Ngomu Akeem Akilimali, Travis K. Hughes, Sarah M. Fortune, Cal Gunnarsson, Sydney L Solomon, Bryan D. Bryson, Gregory H. Babunovic, Brian Hie, Bonnie Berger, Marc H. Wadsworth, Christopher Y. Itoh
Macrophages are central mediators of immunity that integrate diverse signals derived from differentiation cues, tissue location, and disease. Controlling macrophage state and function is an appealing therapeutic objective across many diseases includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ebb541ed325b81f9cbc18c7a30f7184
https://doi.org/10.1101/2020.09.29.318352
https://doi.org/10.1101/2020.09.29.318352
Shigellosis, the primary cause of diarrheal deaths worldwide, particularly affects children living in low and middle-income countries 1 . The causative agent, Shigella spp., invades and replicates in the epithelium of the large intestine, eliciting a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6af6a0755b168dd3ac8b2fa4ed0735
https://doi.org/10.1101/2020.04.25.061671
https://doi.org/10.1101/2020.04.25.061671
Autor:
Sarah M. Fortune, Gregory H. Babunovic, John G. Doench, Timothy K. Lu, Yong Lai, Liang Cui, Peter C. Dedon
SUMMARYExisting antibiotics are inadequate to defeat tuberculosis (TB), a leading cause of death worldwide. We sought potential targets for host-directed therapies (HDTs) by investigating the host immune response to mycobacterial infection. We used C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a81d0d492798dd3d946bd0a20333874
Autor:
Timothy K. Lu, Gregory H. Babunovic, Sarah M. Fortune, Yong Lai, Liang Cui, John G. Doench, Peter C. Dedon
Publikováno v:
bioRxiv
Summary Existing antibiotics are inadequate to defeat tuberculosis (TB), a leading cause of death worldwide. We sought potential targets for host-directed therapies (HDTs) by investigating the host immune response to mycobacterial infection. We used
Publikováno v:
SSRN Electronic Journal.
Shigellosis causes most diarrheal deaths worldwide, particularly affecting children. Shigella invades and replicates in the epithelium of the large intestine, eliciting inflammation and tissue destruction. To understand how Shigella rewires macrophag