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pro vyhledávání: '"Gregory G. Vite"'
Autor:
Mark E. Salvati, Jonathan Lippy, Brian E. Fink, Linda K. Stadnick, Robert V. Moquin, Soong-Hoon Kim, John S. Tokarski, Matthew V. Lorenzi, Gregory G. Vite, Ping Chen, Dan You, Kenneth J. Leavitt, Mary T. Obermeier, George L. Trainor
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
2-Amino-5-(thioaryl)thiazoles are potent inhibitors of TrkA (e.g., 20h , TrkA IC 50 = 0.6 nM) that show anti-proliferative effect in cellular assays. A proposed inhibitor binding mode to TrkA active site is consistent with key SAR observations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15c4b91bfbccc3c0fa591d817fc342e
https://pubmed.ncbi.nlm.nih.gov/18055203
https://pubmed.ncbi.nlm.nih.gov/18055203
