Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gregory E. Jones"'
Autor:
Yelena Kovtun, Gregory E. Jones, Sharlene Adams, Lauren Harvey, Charlene A. Audette, Alan Wilhelm, Chen Bai, Lingyun Rui, Rassol Laleau, Fenghua Liu, Olga Ab, Yulius Setiady, Nicholas C. Yoder, Victor S. Goldmacher, Ravi V.J. Chari, Jan Pinkas, Thomas Chittenden
Publikováno v:
Blood Advances, Vol 2, Iss 8, Pp 848-858 (2018)
Abstract: The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppr
Externí odkaz:
https://doaj.org/article/221c467857af4029b2863119ee489741
Autor:
Wayne C. Widdison, Ravi V.J. Chari, John M. Lambert, Hans K. Erickson, Qifeng Qiu, Rui Wu, Paulin Salomon, Rabih Gabriel, Anna Skaletskaya, Juliet A. Costoplus, Karen Veale, Leanne Lanieri, Jennifer A. Coccia, Gregory E. Jones, Ling Dong, Nathan Fishkin, E. Erica Hong, Katharine C. Lai, Yelena V. Kovtun, Jose Ponte, Yulius Y. Setiady, Rajeeva Singh
Supplementary Methods (S1-S3). Supplementary Method S1: Synthesis of di-, tri-, tetra-glycyl, and valine-citrulline-glycine peptide linkers and catabolites. Supplementary Method S2: Test of in vitro cytotoxicity, cell-cycle inhibition, and bystander
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b6d4b4f9c44ca6353724746b9d8c98
https://doi.org/10.1158/1535-7163.22503028.v1
https://doi.org/10.1158/1535-7163.22503028.v1
Autor:
Wayne C. Widdison, Ravi V.J. Chari, John M. Lambert, Hans K. Erickson, Qifeng Qiu, Rui Wu, Paulin Salomon, Rabih Gabriel, Anna Skaletskaya, Juliet A. Costoplus, Karen Veale, Leanne Lanieri, Jennifer A. Coccia, Gregory E. Jones, Ling Dong, Nathan Fishkin, E. Erica Hong, Katharine C. Lai, Yelena V. Kovtun, Jose Ponte, Yulius Y. Setiady, Rajeeva Singh
Supplementary Table S1: Amounts of catabolites generated upon treatment of cancer cells with CX and SMCC ADCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1bbdc7f0c64a9492add2e343489150
https://doi.org/10.1158/1535-7163.22503025.v1
https://doi.org/10.1158/1535-7163.22503025.v1
Autor:
Wayne C. Widdison, Ravi V.J. Chari, John M. Lambert, Hans K. Erickson, Qifeng Qiu, Rui Wu, Paulin Salomon, Rabih Gabriel, Anna Skaletskaya, Juliet A. Costoplus, Karen Veale, Leanne Lanieri, Jennifer A. Coccia, Gregory E. Jones, Ling Dong, Nathan Fishkin, E. Erica Hong, Katharine C. Lai, Yelena V. Kovtun, Jose Ponte, Yulius Y. Setiady, Rajeeva Singh
Supplementary Figures (S1-S4). Supplementary Figure S1: In vitro cytotoxic activities of tetraglycyl (Gly4), triglycyl (Gly3), diglycyl (Gly2), and valine-citrulline-glycine (VCG)-linked anti-EGFR ADCs and a triglycyl-linked non-binding antibody ADC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dfc500f111def02ff705de4c140fe0
https://doi.org/10.1158/1535-7163.22503031.v1
https://doi.org/10.1158/1535-7163.22503031.v1
Autor:
Ravi V.J. Chari, Victor S. Goldmacher, Rajeeva Singh, Robert J. Lutz, Jan Pinkas, Holly Johnson, Brenda Kellogg, Wayne C. Widdison, Katharine C. Lai, Olga Ab, Sharon Wilhelm, Xiuxia Sun, Hans K. Erickson, Erin K. Maloney, Heather Doherty, Gregory E. Jones, Michele F. Mayo, Charlene A. Audette, Yelena V. Kovtun
Supplementary Tables 1-2, Figures 1-4 from Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa317c3d2229511f14aced6f2534a5d
https://doi.org/10.1158/0008-5472.22385855
https://doi.org/10.1158/0008-5472.22385855
Autor:
Yelena Kovtun, Katharine C. Lai, Kathleen R. Whiteman, Gerrit Jan Schuurhuis, Gert J. Ossenkoppele, P. Noordhuis, Gregory E. Jones, Jan Pinkas, Eunice S. Wang, Lauren Harvey, Sharlene Adams, Callum M. Sloss, Scott Portwood, Krystal Watkins
Publikováno v:
Kovtun, Y, Noordhuis, P, Whiteman, K R, Watkins, K, Jones, G E, Harvey, L, Lai, K C, Portwood, S, Adams, S, Sloss, C M, Schuurhuis, G J, Ossenkoppele, G, Wang, E S & Pinkas, J 2018, ' IMGN779, a Novel CD33-targeting antibody–drug conjugate with DNA-alkylating activity, exhibits potent antitumor activity in models of AML ', Molecular Cancer Therapeutics, vol. 17, no. 6, pp. 1271-1279 . https://doi.org/10.1158/1535-7163.MCT-17-1077
Molecular Cancer Therapeutics, 17(6), 1271-1279. American Association for Cancer Research Inc.
Molecular Cancer Therapeutics, 17(6), 1271-1279. American Association for Cancer Research Inc.
The myeloid differentiation antigen CD33 has long been exploited as a target for antibody-based therapeutic approaches in acute myeloid leukemia (AML). Validation of this strategy was provided with the approval of the CD33-targeting antibody–drug c
Autor:
Chandika Wewelwala, Gregory E. Jones, Roger Berry, Stephen Blamey, Paul Cashin, Daniel Croagh
Publikováno v:
ANZ Journal of Surgery. 87:925-929
Background This study examines the usefulness of early post-operative liver function test (LFT) monitoring in predicting retained choledocholithiasis after laparoscopic common bile duct exploration (LCBDE). Methods Data on patients who had LCBDE over
Autor:
Rui Wu, Leanne Lanieri, Qifeng Qiu, Ravi V. J. Chari, Juliet Costoplus, Yulius Setiady, Rabih Gabriel, E. Erica Hong, Ling Dong, Yelena Kovtun, Nathan Fishkin, Karen Veale, Gregory E. Jones, Wayne C. Widdison, Rajeeva Singh, John M. Lambert, Jose F. Ponte, Katharine C. Lai, Paulin Salomon, Jennifer A. Coccia, Anna Skaletskaya, Hans K. Erickson
Publikováno v:
Molecular cancer therapeutics. 15(6)
A triglycyl peptide linker (CX) was designed for use in antibody–drug conjugates (ADC), aiming to provide efficient release and lysosomal efflux of cytotoxic catabolites within targeted cancer cells. ADCs comprising anti-epithelial cell adhesion mo
Autor:
Ravi V. J. Chari, Yelena Kovtun, Hans K. Erickson, Olga Ab, Robert J. Lutz, Gregory E. Jones, Victor S. Goldmacher, Holly A. Johnson, Heather Doherty, Michele Mayo, Jan Pinkas, Erin K. Maloney, Sharon D. Wilhelm, Wayne C. Widdison, Brenda Kellogg, Xiuxia Sun, Rajeeva Singh, Katharine C. Lai, Charlene Audette
Publikováno v:
Cancer Research. 70:2528-2537
Conjugation of cytotoxic compounds to antibodies that bind to cancer-specific antigens makes these drugs selective in killing cancer cells. However, many of the compounds used in such antibody-drug conjugates (ADC) are substrates for the multidrug tr
Autor:
Christine L. Hartmann Siantar, Joerg Lehmann, Zelanna Goldberg, Michelle L. Arnold, Chad W. Schwietert, David M. Rocke, Thomas P. Daly, Gregory E. Jones, Robin L Stern
Publikováno v:
Radiation Research. 165:240-247
We have developed and validated a practical approach to identifying the location on the skin surface that will receive a prespecified biopsy dose (ranging down to 1 cGy) in support of in vivo biological dosimetry in humans. This represents a signific