Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gregory E. Hardee"'
Publikováno v:
Nephrology Dialysis Transplantation
Treatment of systemic disease with phosphorothioate antisense oligonucleotides (PS ASOs) has been accomplished using local or parenteral routes of administration to date. This report describes, for the first time, the effective oral delivery of a sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebea67f3b1e081676de8fde59f53275d
https://doi.org/10.1002/jps.21084
https://doi.org/10.1002/jps.21084
Autor:
Richard V. Hymas, William I. Higuchi, Gregory E. Hardee, Keiko Tsutsumi, Lloyd G. Tillman, S. Kevin Li, Norman F.H. Ho, Ching-Leou Teng
Publikováno v:
Journal of Pharmaceutical Sciences. 97:350-367
The objective of this study was to mechanistically and quantitatively analyze chenodeoxycholate-enhanced paracellular transport of polar permeants and oligonucleotides in the rat jejunum and ileum. Micellar chenodeoxycholate solutions were used to pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a65057b2d8aabba048da6c5992b6ab
https://doi.org/10.1002/jps.21093
https://doi.org/10.1002/jps.21093
Publikováno v:
Journal of Investigative Dermatology. 124:971-975
Antisense oligodeoxynucleotides formulated in cream preparations are being examined in the clinic as topical therapy for psoriasis. To produce their intended anti-inflammatory effects, these large anionic molecules must penetrate the stratum corneum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef875da42ba6dc488a9a6d4b4ffc37f
https://doi.org/10.1111/j.0022-202x.2005.23672.x
https://doi.org/10.1111/j.0022-202x.2005.23672.x
Autor:
Gregory E. Hardee, Marı́a González Ferreiro, Roland Bodmeier, Rosanne M. Crooke, Lloyd G. Tillman
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 55:19-26
Presystemic degradation in the gastrointestinal tract is one of the major problems contributing to the poor oral absorption of antisense oligonucleotides. Complexes between the antisense phosphorothioate oligodeoxynucleotide ISIS 2302 and the polycat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b534377f3f2d497cc3b170d584bd3c
https://doi.org/10.1016/s0939-6411(02)00140-6
https://doi.org/10.1016/s0939-6411(02)00140-6
Publikováno v:
Pharmaceutical Research. 19:755-764
Purpose. A microparticle carrier based on alginate and poly-L-lysine was developed and evaluated for the delivery of antisense oligonucleotides at the intestinal site. Formulations of oligonucleotide-loaded microparticles having differences in the ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff5430156bbf3da21200cd10ffd73bd
https://doi.org/10.1023/a:1016188312399
https://doi.org/10.1023/a:1016188312399
Characterization of complexes of an antisense oligonucleotide with protamine and poly-l-lysine salts
Publikováno v:
Journal of Controlled Release. 73:381-390
The objectives of this work were to study the interaction of an antisense oligonucleotide (ISIS 2302) with poly- l -lysine (PLL) and protamine salts, to determine the physico–chemical characteristics of the resulting complex systems and to analyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e857ecf73c28cdb30d1c53378bcd89f
https://doi.org/10.1016/s0168-3659(01)00296-6
https://doi.org/10.1016/s0168-3659(01)00296-6
Autor:
Weiqi Lin, Samiee Ahmad P, Gregory E. Hardee, Ching-Leou Teng, Michel J. N. Cormier, Angie Griffin, Peter E. Daddona, Bonny Johnson
Publikováno v:
Pharmaceutical Research. 18:1789-1793
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42c5a90929dde8fbd8d06e6ff2a65799
https://doi.org/10.1023/a:1013395102049
https://doi.org/10.1023/a:1013395102049
Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres
Publikováno v:
Journal of Controlled Release. 69:197-207
The objective of this study was to encapsulate an oligonucleotide drug within poly(lactide) microparticles with high encapsulation efficiencies at high theoretical drug loadings by the solvent evaporation method. With the conventional W/O/W method, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6533bfa86bc03baee88b512b25786fc
https://doi.org/10.1016/s0168-3659(00)00299-6
https://doi.org/10.1016/s0168-3659(00)00299-6
Publikováno v:
Pharmaceutical Development and Technology. 2:323-334
Polymeric microparticles containing two ceftiofur salts as antimicrobial agents for intramammary application in dry cows were prepared by modified o/w-solvent evaporation methods (dispersion or cosolvent method) or by a w/o/w-multiple emulsion solven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a937b9704fcebff149d87396f9e975
https://doi.org/10.3109/10837459709022631
https://doi.org/10.3109/10837459709022631
Autor:
Gregory E Hardee
Publikováno v:
Therapeutic delivery. 3(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8c101ec6cb1165cb4bd257a5a4fac8
https://pubmed.ncbi.nlm.nih.gov/22834192
https://pubmed.ncbi.nlm.nih.gov/22834192