Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gregory E. Garcia"'
Publikováno v:
Magnetic Resonance in Chemistry. 52:111-114
Cyclodextrins are torus-shaped polymers of glucose that can bind organophosphorous compounds such as nerve agents and pesticides. We demonstrate here that cyclodextrin can bind up to two paraoxon molecules with a K(av) of 6775 M(-1). Molecular modeli
Autor:
Alessandro Pesaresi, Maria Laura Bolognesi, Jan Korabecny, Marinella Roberti, Vincenza Andrisano, Manuela Bartolini, Barbara Monti, Luis Emiliano Peña-Altamira, Sarah Samez, Eugenie Nepovimova, Christian Bergamini, Kamil Kuca, Elisa Uliassi, Doriano Lamba, Gregory E. Garcia, Romana Fato
Publikováno v:
Journal of medicinal chemistry 57 (2014): 8576–8589. doi:10.1021/jm5010804
info:cnr-pdr/source/autori:Nepovímová, Eugenie; Uliassi, Elisa; Korábecný, Jan; Peña-Altamira, Luis Emiliano; Samez, Sarah; Pesaresi, Alessandro; Garcia, Gregory E.; Bartolini, Manuela; Andrisano, Vincenza; Bergamini, Christian; Fato, Romana; Lamba, Doriano; Roberti, Marinella; Kuca, Kamil; Monti, Barbara; Bolognesi, M. L./titolo:Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects/doi:10.1021%2Fjm5010804/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:8576/pagina_a:8589/intervallo_pagine:8576–8589/volume:57
info:cnr-pdr/source/autori:Nepovímová, Eugenie; Uliassi, Elisa; Korábecný, Jan; Peña-Altamira, Luis Emiliano; Samez, Sarah; Pesaresi, Alessandro; Garcia, Gregory E.; Bartolini, Manuela; Andrisano, Vincenza; Bergamini, Christian; Fato, Romana; Lamba, Doriano; Roberti, Marinella; Kuca, Kamil; Monti, Barbara; Bolognesi, M. L./titolo:Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects/doi:10.1021%2Fjm5010804/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:8576/pagina_a:8589/intervallo_pagine:8576–8589/volume:57
We report the identification of multitarget anti-Alzheimer compounds designed by combining a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed excellent acetylcholinesterase (AChE) inhibitory potencies and interesting c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9a310ccd9288b2eeb50fe56ae16810
http://hdl.handle.net/11585/384369
http://hdl.handle.net/11585/384369
Autor:
Lionel Biggemann, Manojkumar Valiyaveettil, Radley Short, Iswarduth Soojhawon, Madhusoodana P. Nambiar, Savita V. Nigam, Michael Costante, Gregory E. Garcia, Yonas Alamneh, Bhupendra P. Doctor
Publikováno v:
Toxicology in Vitro. 26:182-188
Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. To develop PROL as a catalytic bios
Autor:
Bryan J. McCranor, Melissa A. Olert, Deborah Moorad-Doctor, Catherine A. Hofstetter, Gregory E. Garcia, Douglas M. Cerasoli
Publikováno v:
Chemico-biological interactions. 259
To develop a prophylactic for organophosphorus (OP) poisoning utilizing catalytic bioscavengers, the circulatory stability of the enzymes needs to be increased. One strategy for increasing the bioavailability of OP bioscavengers is to target them to
Publikováno v:
Journal of Cellular Biochemistry. 105:129-135
BoNT/B holotoxin (HT) from the native source is a mixture of nicked and un-nicked forms. A previous study showed that while un-nicked HT could be transcytosed by intestinal epithelial cells, they did not correlate this with proteolytic activity or bi
Autor:
Andres Castillo, Deborah Moorad-Doctor, Ruthie H Ratcliffe, Gregory E. Garcia, Harry Singh, Katie Wachtel
Publikováno v:
Journal of Analytical Toxicology. 31:69-74
A rapid and sensitive assay for pyridinium oximes in plasma and tissue was developed. The method was suitable for the analysis of mono- and di-pyridinium oximes and utilizes ultrafiltration followed by cation-exchange high-performance liquid chromato
Publikováno v:
Toxicology and applied pharmacology. 287(3)
Chemical warfare nerve agents (CWNAs) are highly toxic compounds that cause a cascade of symptoms and death, if exposed casualties are left untreated. Numerous rodent models have investigated the toxicity and mechanisms of toxicity of CWNAs, but most
Clostridium botulinum bacteria produce botulinum neurotoxin (BoNT) which can be developed as a bioweapon. Currently no FDA-licensed prophylactic product is available in the USA against botulism. Small molecules are being developed for use as inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ccbceb22252dc64300ad0c0ec221c7
https://doi.org/10.21236/ada612876
https://doi.org/10.21236/ada612876
Publikováno v:
Frontiers in Neurology
Frontiers in Neurology, Vol 5 (2014)
Frontiers in Neurology, Vol 5 (2014)
Neuropsychiatric disorders are one of the leading causes of disability worldwide and affect the health of billions of people. Previous publications have demonstrated that neuropsychiatric disorders can cause histomorphological damage in particular re
Publikováno v:
Journal of Applied Toxicology. 19:S19-S22
Botulinum neurotoxin B (BoNT/B) serotype specifically cleaves between the amino acids glutamine and phenylalanine (Q and F bond) in position 76-77 of synaptobrevin (VAMP2). We evaluated peptides that contain the QF cleavage site but are not identical