Výsledky vyhledávání - "Gregory E. Garcia"

Biophysical aspects of cyclodextrin interaction with paraoxon

Autor: Sunil-Datta Soni, Jayendra B. Bhonsle, Gregory E. Garcia

Publikováno v: Magnetic Resonance in Chemistry. 52:111-114

Cyclodextrins are torus-shaped polymers of glucose that can bind organophosphorous compounds such as nerve agents and pesticides. We demonstrate here that cyclodextrin can bind up to two paraoxon molecules with a K(av) of 6775 M(-1). Molecular modeli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f2fcba44fae0e04b88ae2c448a2c696
https://doi.org/10.1002/mrc.4036

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Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

Autor: Alessandro Pesaresi, Maria Laura Bolognesi, Jan Korabecny, Marinella Roberti, Vincenza Andrisano, Manuela Bartolini, Barbara Monti, Luis Emiliano Peña-Altamira, Sarah Samez, Eugenie Nepovimova, Christian Bergamini, Kamil Kuca, Elisa Uliassi, Doriano Lamba, Gregory E. Garcia, Romana Fato

Publikováno v: Journal of medicinal chemistry 57 (2014): 8576–8589. doi:10.1021/jm5010804
info:cnr-pdr/source/autori:Nepovímová, Eugenie; Uliassi, Elisa; Korábecný, Jan; Peña-Altamira, Luis Emiliano; Samez, Sarah; Pesaresi, Alessandro; Garcia, Gregory E.; Bartolini, Manuela; Andrisano, Vincenza; Bergamini, Christian; Fato, Romana; Lamba, Doriano; Roberti, Marinella; Kuca, Kamil; Monti, Barbara; Bolognesi, M. L./titolo:Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects/doi:10.1021%2Fjm5010804/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:8576/pagina_a:8589/intervallo_pagine:8576–8589/volume:57

We report the identification of multitarget anti-Alzheimer compounds designed by combining a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed excellent acetylcholinesterase (AChE) inhibitory potencies and interesting c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9a310ccd9288b2eeb50fe56ae16810
http://hdl.handle.net/11585/384369

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Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis

Autor: Lionel Biggemann, Manojkumar Valiyaveettil, Radley Short, Iswarduth Soojhawon, Madhusoodana P. Nambiar, Savita V. Nigam, Michael Costante, Gregory E. Garcia, Yonas Alamneh, Bhupendra P. Doctor

Publikováno v: Toxicology in Vitro. 26:182-188

Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. To develop PROL as a catalytic bios

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a16876bdef14b594fd6dcaeef4a2992
https://doi.org/10.1016/j.tiv.2011.11.006

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Targeting of organophosphorus compound bioscavengers to the surface of red blood cells

Autor: Bryan J. McCranor, Melissa A. Olert, Deborah Moorad-Doctor, Catherine A. Hofstetter, Gregory E. Garcia, Douglas M. Cerasoli

Publikováno v: Chemico-biological interactions. 259

To develop a prophylactic for organophosphorus (OP) poisoning utilizing catalytic bioscavengers, the circulatory stability of the enzymes needs to be increased. One strategy for increasing the bioavailability of OP bioscavengers is to target them to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1829a3288034ff7ce4a75da05631d1
https://pubmed.ncbi.nlm.nih.gov/27163849

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Un-nicked BoNT/B activity in human SHSY-5Y neuronal cells

Autor: Xuerong Shi, Madhusoodana P. Nambiar, Richard K. Gordon, Gregory E. Garcia

Publikováno v: Journal of Cellular Biochemistry. 105:129-135

BoNT/B holotoxin (HT) from the native source is a mixture of nicked and un-nicked forms. A previous study showed that while un-nicked HT could be transcytosed by intestinal epithelial cells, they did not correlate this with proteolytic activity or bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed32fc03c256422acd8bff7ab1bb3103
https://doi.org/10.1002/jcb.21800

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A Rapid Cation-Exchange HPLC Method for Detection and Quantification of Pyridinium Oximes in Plasma and Tissue

Autor: Andres Castillo, Deborah Moorad-Doctor, Ruthie H Ratcliffe, Gregory E. Garcia, Harry Singh, Katie Wachtel

Publikováno v: Journal of Analytical Toxicology. 31:69-74

A rapid and sensitive assay for pyridinium oximes in plasma and tissue was developed. The method was suitable for the analysis of mono- and di-pyridinium oximes and utilizes ultrafiltration followed by cation-exchange high-performance liquid chromato

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https://doi.org/10.1093/jat/31.2.69

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Hormone-dependence of sarin lethality in rats: Sex differences and stage of the estrous cycle

Autor: Gregory E. Garcia, Robyn B. Lee, Linnzi K.M. Wright, Lucille A. Lumley, Carl D. Smith

Publikováno v: Toxicology and applied pharmacology. 287(3)

Chemical warfare nerve agents (CWNAs) are highly toxic compounds that cause a cascade of symptoms and death, if exposed casualties are left untreated. Numerous rodent models have investigated the toxicity and mechanisms of toxicity of CWNAs, but most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448d5f7736e25b31dab5fd1035d865d3
https://pubmed.ncbi.nlm.nih.gov/26079828

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Identification of Small Molecules against Botulinum Neurotoxin B Binding to Neuronal Cells at Ganglioside GT1b Binding Site with Low to Moderate Affinity

Autor: Gregory E Garcia, Carolyn Chambers, Nagarajan Pattabiraman, Ayesha Adil

Clostridium botulinum bacteria produce botulinum neurotoxin (BoNT) which can be developed as a bioweapon. Currently no FDA-licensed prophylactic product is available in the USA against botulism. Small molecules are being developed for use as inhibito

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https://doi.org/10.21236/ada612876

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The Involvement of Secondary Neuronal Damage in the Development of Neuropsychiatric Disorders Following Brain Insults

Autor: Shlomi Constantini, Gregory E. Garcia, Wei Huang, Yun Chen

Publikováno v: Frontiers in Neurology
Frontiers in Neurology, Vol 5 (2014)

Neuropsychiatric disorders are one of the leading causes of disability worldwide and affect the health of billions of people. Previous publications have demonstrated that neuropsychiatric disorders can cause histomorphological damage in particular re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691c901e8d829e83d09dcde37aec2aae
http://europepmc.org/articles/PMC3949352

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Buforin I, a natural peptide, inhibits botulinum neurotoxin B activity in vitro

Autor: Gregory E. Garcia, Richard K. Gordon, Deborah R. Moorad

Publikováno v: Journal of Applied Toxicology. 19:S19-S22

Botulinum neurotoxin B (BoNT/B) serotype specifically cleaves between the amino acids glutamine and phenylalanine (Q and F bond) in position 76-77 of synaptobrevin (VAMP2). We evaluated peptides that contain the QF cleavage site but are not identical

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https://doi.org/10.1002/(sici)1099-1263(199912)19:1+3.0.co

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