Výsledky vyhledávání - "Gregory E. Conner"

Akademický článek

NADPH Alters DUOX1 Calcium Responsiveness

Autor: Gregory E. Conner

Publikováno v: Redox Biology, Vol 75, Iss , Pp 103251- (2024)

Hydrogen peroxide is a key element in redox signaling and in setting cellular redox tone. DUOX1 and DUOX2, that directly synthesize hydrogen peroxide, are the most abundant NADPH oxidase transcripts in most epithelia. DUOX1 and DUOX2 hydrogen peroxid

Externí odkaz: https://doaj.org/article/82da1bb95ebf4191bfeffe2d7e429c9a

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Akademický článek

Regulation of dual oxidase hydrogen peroxide synthesis results in an epithelial respiratory burst

Autor: Gregory E. Conner

Publikováno v: Redox Biology, Vol 41, Iss , Pp 101931- (2021)

Redox status is a central determinant of cellular activities and redox imbalance is correlated with numerous diseases. NADPH oxidase activity results in formation of H2O2, that, in turn, sets cellular redox status, a key regulator of cellular homeost

Externí odkaz: https://doaj.org/article/89246a34ad16457e86ae9af533c14213

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Akademický článek

Proton channel blockers inhibit Duox activity independent of Hv1 effects

Autor: Monica Valencia Gattas, Adam Jaffe, Juliana Barahona, Gregory E. Conner

Publikováno v: Redox Biology, Vol 28, Iss , Pp - (2020)

The NADPH oxidase reaction produces protons. In the case of the NADPH oxidase, NOX2, activity depends on secretion of these protons and is inhibited by blockade of the voltage-gated proton channel (Hv1). Duox1 and Duox2 activities similarly produce i

Externí odkaz: https://doaj.org/article/7b2fbabcdd3c4669ba44763bc616d689

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Akademický článek

Intestinal Epithelial Cells Respond to Chronic Inflammation and Dysbiosis by Synthesizing H2O2

Autor: Juan F. Burgueño, Julia Fritsch, Ana M. Santander, Nivis Brito, Irina Fernández, Judith Pignac-Kobinger, Gregory E. Conner, Maria T. Abreu

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

The microbes in the gastrointestinal tract are separated from the host by a single layer of intestinal epithelial cells (IECs) that plays pivotal roles in maintaining homeostasis by absorbing nutrients and providing a physical and immunological barri

Externí odkaz: https://doaj.org/article/fc5ed3aadf3049149fb2085d90d048e7

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Akademický článek

High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure

Autor: Gerhard P. Dahl, Gregory E. Conner, Feng Qiu, Junjie Wang, Edward Spindler, Jason A. Campagna, H. Peter Larsson

Publikováno v: EBioMedicine, Vol 10, Iss C, Pp 291-297 (2016)

Clevidipine, a dihydropyridine (DHP) analogue, lowers blood pressure (BP) by inhibiting l-type calcium channels (CaV1.2; gene CACNA1C) predominantly located in vascular smooth muscle (VSM). However, clinical observations suggest that clevidipine acts

Externí odkaz: https://doaj.org/article/3196549b2b8c4a0a8ac181bd695efb67

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Akademický článek

Rapid corticosteroid effect on long-acting beta2-agonist disposal by smooth muscle cells in the airway: a new paradigm of inhaled combination therapy

Autor: Gabor Horvath, Eliana S. Mendes, Nathalie Schmid, Andreas Schmid, Gregory E. Conner, Matthias Salathe, Adam Wanner

Publikováno v: European Respiratory Review, Vol 17, Iss 107, Pp 41-42 (2008)

Organic cation transporters (OCTs) have an important role in tissue distribution and elimination of cationic drugs. To assess airway disposal of cationic bronchodilators, human airway cells and tissues obtained from organ donors were evaluated for dr

Externí odkaz: https://doaj.org/article/d83095d95eaf49008b109d792c7c8531

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