Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gregory E Bigford"'
Autor:
Gregory E Bigford, Angela Szeto, John Kimball, Edward E Herderick, Armando J Mendez, Mark S Nash
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246601 (2021)
ObjectiveTo test in mice with a double mutation of the ApoE gene (ApoE-/-) whether spinal cord injury (SCI) hastens the native trajectory of, and established component risks for, atherosclerotic disease (AD), and whether Salsalate anti-inflammatory p
Externí odkaz:
https://doaj.org/article/0928097151bd4907a0f6c1162fec7eec
Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury.
Autor:
Gregory E Bigford, Andrew J Darr, Valerie C Bracchi-Ricard, Han Gao, Mark S Nash, John R Bethea
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203042 (2018)
Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation from slow oxidative to fast glycolytic, both contributing to functional deficits and maladaptive metabolic profiles. Therapeutic countermeasures have
Externí odkaz:
https://doaj.org/article/8728bec28a6d45a297dff807e734fb8e
Autor:
Joshua M. Poulin, Gregory E. Bigford, Krista L. Lanctôt, Peter Giacobbe, Ayal Schaffer, Mark Sinyor, Jennifer S. Rabin, Mario Masellis, Amit Singnurkar, Christopher B. Pople, Nir Lipsman, Muhammad I. Husain, Joshua D. Rosenblat, Xingshan Cao, Bradley J. MacIntosh, Sean M. Nestor
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Major depressive disorder (MDD) is a leading cause of disability worldwide across domains of health and cognition, affecting overall quality of life. Approximately one third of individuals with depression do not fully respond to t
Externí odkaz:
https://doaj.org/article/8958465c86ef44d6807fc658be7eb838
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41073 (2012)
Chronic spinal cord injury (SCI) results in an accelerated trajectory of several cardiovascular disease (CVD) risk factors and related aging characteristics, however the molecular mechanisms that are activated have not been explored. Adipokines and l
Externí odkaz:
https://doaj.org/article/511b7a79c87049cdb1b44dcaec1af79a
Publikováno v:
Obesity Facts, Pp 1-1 (2023)
Background: A spinal cord injury (SCI) from trauma or disease impairs sensorimotor pathways in somatic and autonomic divisions of the nervous system, affecting multiple body systems. Improved medical practices have increased survivability and life ex
Externí odkaz:
https://doaj.org/article/61a5af57403841478273d50ac6bbda8f
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 842 (2020)
The activity of the hypothalamus–pituitary–adrenal (HPA) axis is pivotal in homeostasis and presides the adaptative response to stress. Dopamine Transporter (DAT) plays a key role in the regulation of the HPA axis. We used young adult female DAT
Externí odkaz:
https://doaj.org/article/08a74e221a234763a7cd78e868149459
Publikováno v:
Journal of Neurotrauma. 38:3440-3455
Clinically relevant myopenia accompanies spinal cord injury (SCI), and compromises function, metabolism, body composition, and health. Myostatin, a transforming growth factor (TGF)β family member, is a key negative regulator of skeletal muscle mass.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f6c686541144391e954e50facbf9d4
https://doi.org/10.1089/neu.2021.0061
https://doi.org/10.1089/neu.2021.0061
Autor:
Gregory E, Bigford, Eric, Garshick
Publikováno v:
Current Opinion in Pharmacology. 67:102303
Individuals with chronic traumatic spinal cord injury (SCI) develop progressive multi-system health problems that result in clinical illness and disability. Systemic inflammation is associated with many of the common medical complications and acquire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c24b5d810945d7eb125b12b49246aeb
https://doi.org/10.1016/j.coph.2022.102303
https://doi.org/10.1016/j.coph.2022.102303
Autor:
Gregory E. Bigford, Mark S. Nash
Publikováno v:
Topics in Spinal Cord Injury Rehabilitation. 23:188-206
Chronic spinal cord injury (SCI) often results in morbidity and mortality due to all-cause cardiovascular disease (CVD) and comorbid endocrine disorders. Several component risk factors for CVD, described as the cardiometabolic syndrome (CMS), are pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4182f3708ea79f26075b3ab7978249ac
https://doi.org/10.1310/sci2303-188
https://doi.org/10.1310/sci2303-188
Autor:
Han Gao, Gregory E. Bigford, Andrew J. Darr, John R. Bethea, Valerie Bracchi-Ricard, Mark S. Nash
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203042 (2018)
Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation from slow oxidative to fast glycolytic, both contributing to functional deficits and maladaptive metabolic profiles. Therapeutic countermeasures have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78506471a3fafafa649f8e3b46707634
https://pubmed.ncbi.nlm.nih.gov/30157245
https://pubmed.ncbi.nlm.nih.gov/30157245